Classical conditioning, decay and extinction of cocaine-induced hyperactivity and stereotypy

Gordon A. Barr, Nansie S. Sharpless, Stanley Cooper, Stanley R. Schiff, William Paredes, Wagner H. Bridger

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

Following 10 daily pairings of multiple conditioned stimuli with injection of cocaine (15 mg/kg), the presentation of the stimuli alone elicited behaviors in rats similar to those induced by cocaine. The behaviors included increased duration or frequency of rearing, sniffing, head bobbing, and horizontal locomotor activity (crossing). The level of the conditioned response for several of these behaviors approximated that induced by the drug itself. The conditioned drug effect showed decay over 15 days but little extinction during 4 daily trials. Brain concentrations of the dopamine metabolites, homovanillic acid and dihydroxyphenylacetic acid, were similar in the conditioned and pseudoconditioned control groups in both the caudate and mesolimbic areas. The behavioral results demonstrate that, in a classical conditioning paradigm, previously neutral stimuli can elicit behaviors similar to those induced by cocaine and that certain conditioned responses show time related decline. This agress with the reported conditioning of amphetamine's behavioral effects but differs in terms of the action on brain dopamine turnover.

Original languageEnglish (US)
Pages (from-to)1341-1351
Number of pages11
JournalLife Sciences
Volume33
Issue number14
DOIs
StatePublished - Oct 3 1983

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Classical Conditioning
Cocaine
Dopamine
Brain
Homovanillic Acid
Locomotion
Metabolites
Pharmaceutical Preparations
Rats
Head
Control Groups
Injections
Acids
Psychological Extinction

ASJC Scopus subject areas

  • Pharmacology

Cite this

Classical conditioning, decay and extinction of cocaine-induced hyperactivity and stereotypy. / Barr, Gordon A.; Sharpless, Nansie S.; Cooper, Stanley; Schiff, Stanley R.; Paredes, William; Bridger, Wagner H.

In: Life Sciences, Vol. 33, No. 14, 03.10.1983, p. 1341-1351.

Research output: Contribution to journalArticle

Barr, Gordon A. ; Sharpless, Nansie S. ; Cooper, Stanley ; Schiff, Stanley R. ; Paredes, William ; Bridger, Wagner H. / Classical conditioning, decay and extinction of cocaine-induced hyperactivity and stereotypy. In: Life Sciences. 1983 ; Vol. 33, No. 14. pp. 1341-1351.
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