Class reunion: PTEN joins the nuclear crew

Zenglin Lian; Antonio Di Cristofano

doi:10.1038/sj.onc.1209089

Class reunion: PTEN joins the nuclear crew

Zenglin Lian, Antonio Di Cristofano

Research output: Contribution to journal › Review article › peer-review

97 Scopus citations

Abstract

Several recent reports have brought conclusive evidence that the tumor suppressor PTEN, once considered a strictly cytoplasmic protein, shuttles to the nuclear compartment, where it joins a variety of components of the same pathway it regulates in the cytoplasm, among which PI3K, PDK1 and AKT. In this review, we focus on the growing supporting evidence for an important physiological role of this nuclear pathway and on the role that alteration of this novel regulatory circuit may play during cell transformation.

Original language	English (US)
Pages (from-to)	7394-7400
Number of pages	7
Journal	Oncogene
Volume	24
Issue number	50
DOIs	https://doi.org/10.1038/sj.onc.1209089
State	Published - Nov 14 2005
Externally published	Yes

Keywords

AKT
Nucleus
PTEN

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/sj.onc.1209089

Cite this

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title = "Class reunion: PTEN joins the nuclear crew",

abstract = "Several recent reports have brought conclusive evidence that the tumor suppressor PTEN, once considered a strictly cytoplasmic protein, shuttles to the nuclear compartment, where it joins a variety of components of the same pathway it regulates in the cytoplasm, among which PI3K, PDK1 and AKT. In this review, we focus on the growing supporting evidence for an important physiological role of this nuclear pathway and on the role that alteration of this novel regulatory circuit may play during cell transformation.",

keywords = "AKT, Nucleus, PTEN",

author = "Zenglin Lian and {Di Cristofano}, Antonio",

note = "Funding Information: This work was supported by the National Institute of Health grant CA097097 to ADC and by an appropriation from the Commonwealth of Pennsylvania.",

year = "2005",

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language = "English (US)",

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T2 - PTEN joins the nuclear crew

AU - Lian, Zenglin

AU - Di Cristofano, Antonio

N1 - Funding Information: This work was supported by the National Institute of Health grant CA097097 to ADC and by an appropriation from the Commonwealth of Pennsylvania.

PY - 2005/11/14

Y1 - 2005/11/14

N2 - Several recent reports have brought conclusive evidence that the tumor suppressor PTEN, once considered a strictly cytoplasmic protein, shuttles to the nuclear compartment, where it joins a variety of components of the same pathway it regulates in the cytoplasm, among which PI3K, PDK1 and AKT. In this review, we focus on the growing supporting evidence for an important physiological role of this nuclear pathway and on the role that alteration of this novel regulatory circuit may play during cell transformation.

AB - Several recent reports have brought conclusive evidence that the tumor suppressor PTEN, once considered a strictly cytoplasmic protein, shuttles to the nuclear compartment, where it joins a variety of components of the same pathway it regulates in the cytoplasm, among which PI3K, PDK1 and AKT. In this review, we focus on the growing supporting evidence for an important physiological role of this nuclear pathway and on the role that alteration of this novel regulatory circuit may play during cell transformation.

KW - AKT

KW - Nucleus

KW - PTEN

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JO - Oncogene

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ER -

Class reunion: PTEN joins the nuclear crew

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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