Class reunion: PTEN joins the nuclear crew

Zenglin Lian, Antonio Di Cristofano

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

Several recent reports have brought conclusive evidence that the tumor suppressor PTEN, once considered a strictly cytoplasmic protein, shuttles to the nuclear compartment, where it joins a variety of components of the same pathway it regulates in the cytoplasm, among which PI3K, PDK1 and AKT. In this review, we focus on the growing supporting evidence for an important physiological role of this nuclear pathway and on the role that alteration of this novel regulatory circuit may play during cell transformation.

Original languageEnglish (US)
Pages (from-to)7394-7400
Number of pages7
JournalOncogene
Volume24
Issue number50
DOIs
StatePublished - Nov 14 2005
Externally publishedYes

Fingerprint

Reunion
Phosphatidylinositol 3-Kinases
Cytoplasm
Neoplasms
Proteins

Keywords

  • AKT
  • Nucleus
  • PTEN

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research
  • Genetics

Cite this

Class reunion : PTEN joins the nuclear crew. / Lian, Zenglin; Di Cristofano, Antonio.

In: Oncogene, Vol. 24, No. 50, 14.11.2005, p. 7394-7400.

Research output: Contribution to journalArticle

Lian, Zenglin ; Di Cristofano, Antonio. / Class reunion : PTEN joins the nuclear crew. In: Oncogene. 2005 ; Vol. 24, No. 50. pp. 7394-7400.
@article{5968ba4dfb154453a647a442ac377df6,
title = "Class reunion: PTEN joins the nuclear crew",
abstract = "Several recent reports have brought conclusive evidence that the tumor suppressor PTEN, once considered a strictly cytoplasmic protein, shuttles to the nuclear compartment, where it joins a variety of components of the same pathway it regulates in the cytoplasm, among which PI3K, PDK1 and AKT. In this review, we focus on the growing supporting evidence for an important physiological role of this nuclear pathway and on the role that alteration of this novel regulatory circuit may play during cell transformation.",
keywords = "AKT, Nucleus, PTEN",
author = "Zenglin Lian and {Di Cristofano}, Antonio",
year = "2005",
month = "11",
day = "14",
doi = "10.1038/sj.onc.1209089",
language = "English (US)",
volume = "24",
pages = "7394--7400",
journal = "Oncogene",
issn = "0950-9232",
publisher = "Nature Publishing Group",
number = "50",

}

TY - JOUR

T1 - Class reunion

T2 - PTEN joins the nuclear crew

AU - Lian, Zenglin

AU - Di Cristofano, Antonio

PY - 2005/11/14

Y1 - 2005/11/14

N2 - Several recent reports have brought conclusive evidence that the tumor suppressor PTEN, once considered a strictly cytoplasmic protein, shuttles to the nuclear compartment, where it joins a variety of components of the same pathway it regulates in the cytoplasm, among which PI3K, PDK1 and AKT. In this review, we focus on the growing supporting evidence for an important physiological role of this nuclear pathway and on the role that alteration of this novel regulatory circuit may play during cell transformation.

AB - Several recent reports have brought conclusive evidence that the tumor suppressor PTEN, once considered a strictly cytoplasmic protein, shuttles to the nuclear compartment, where it joins a variety of components of the same pathway it regulates in the cytoplasm, among which PI3K, PDK1 and AKT. In this review, we focus on the growing supporting evidence for an important physiological role of this nuclear pathway and on the role that alteration of this novel regulatory circuit may play during cell transformation.

KW - AKT

KW - Nucleus

KW - PTEN

UR - http://www.scopus.com/inward/record.url?scp=27844535741&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=27844535741&partnerID=8YFLogxK

U2 - 10.1038/sj.onc.1209089

DO - 10.1038/sj.onc.1209089

M3 - Article

C2 - 16288286

AN - SCOPUS:27844535741

VL - 24

SP - 7394

EP - 7400

JO - Oncogene

JF - Oncogene

SN - 0950-9232

IS - 50

ER -