Class reunion: PTEN joins the nuclear crew

Zenglin Lian, Antonio Di Cristofano

Research output: Contribution to journalReview article

97 Scopus citations

Abstract

Several recent reports have brought conclusive evidence that the tumor suppressor PTEN, once considered a strictly cytoplasmic protein, shuttles to the nuclear compartment, where it joins a variety of components of the same pathway it regulates in the cytoplasm, among which PI3K, PDK1 and AKT. In this review, we focus on the growing supporting evidence for an important physiological role of this nuclear pathway and on the role that alteration of this novel regulatory circuit may play during cell transformation.

Original languageEnglish (US)
Pages (from-to)7394-7400
Number of pages7
JournalOncogene
Volume24
Issue number50
DOIs
StatePublished - Nov 14 2005
Externally publishedYes

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Keywords

  • AKT
  • Nucleus
  • PTEN

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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