Abstract
Several recent reports have brought conclusive evidence that the tumor suppressor PTEN, once considered a strictly cytoplasmic protein, shuttles to the nuclear compartment, where it joins a variety of components of the same pathway it regulates in the cytoplasm, among which PI3K, PDK1 and AKT. In this review, we focus on the growing supporting evidence for an important physiological role of this nuclear pathway and on the role that alteration of this novel regulatory circuit may play during cell transformation.
Original language | English (US) |
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Pages (from-to) | 7394-7400 |
Number of pages | 7 |
Journal | Oncogene |
Volume | 24 |
Issue number | 50 |
DOIs | |
State | Published - Nov 14 2005 |
Externally published | Yes |
Keywords
- AKT
- Nucleus
- PTEN
ASJC Scopus subject areas
- Molecular Biology
- Genetics
- Cancer Research