Class II virus membrane fusion proteins

Research output: Contribution to journalArticle

133 Citations (Scopus)

Abstract

Enveloped animal viruses fuse their membrane with a host cell membrane, thus delivering the virus genetic material into the cytoplasm and initiating infection. This critical membrane fusion reaction is mediated by a virus transmembrane protein known as the fusion protein, which inserts its hydrophobic fusion peptide into the cell membrane and refolds to drive the fusion reaction. This review describes recent advances in our understanding of the structure and function of the class II fusion proteins of the alphaviruses and flaviviruses. Inhibition of the fusion protein refolding reaction confirms its importance in fusion and suggests new antiviral strategies for these medically important viruses.

Original languageEnglish (US)
Pages (from-to)38-47
Number of pages10
JournalVirology
Volume344
Issue number1
DOIs
StatePublished - Jan 5 2006

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Membrane Fusion Proteins
Viral Fusion Proteins
Virus Internalization
Viruses
Cell Membrane
Protein Refolding
Alphavirus
Flavivirus
Proteins
Membrane Fusion
Antiviral Agents
Cytoplasm
Peptides
Membranes
Infection
Genes

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Class II virus membrane fusion proteins. / Kielian, Margaret.

In: Virology, Vol. 344, No. 1, 05.01.2006, p. 38-47.

Research output: Contribution to journalArticle

Kielian, Margaret. / Class II virus membrane fusion proteins. In: Virology. 2006 ; Vol. 344, No. 1. pp. 38-47.
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