Circulating vitamin D correlates with serum antimüllerian hormone levels in late-reproductive-aged women: Women's Interagency HIV Study

Zaher O. Merhi, David B. Seifer, Jeremy Weedon, Oluwatoyin Adeyemi, Susan Holman, Kathryn Anastos, Elizabeth T. Golub, Mary Young, Roksana Karim, Ruth Greenblatt, Howard Minkoff

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Objective: To study the correlation between circulating 25-hydroxyvitamin D (25OH-D) levels and serum antimüllerian hormone (AMH) in women enrolled in the Women's Interagency HIV Study. Design: Cross-sectional study. Setting: None. Patient(s): All premenopausal women (n = 388) with regular menstrual cycles were included and subdivided into three groups: group 1 with age <35 years (n = 128), group 2 with age 35-39 years (n = 119), and group 3 with age ≥40 years (n = 141). Intervention(s): Serum for 25OH-D, AMH, fasting glucose and insulin, and creatinine levels. Main Outcome Measure(s): Correlation between 25OH-D and AMH before and after adjusting for HIV status, body mass index, race, smoking, illicit drug use, glucose and insulin levels, estimated glomerular filtration rate, and geographic site of participation. Result(s): After adjusting for all covariates, the regression slope in all participants for total 25OH-D predicting log 10AMH for 25-year-olds (youngest participant) was -0.001 (SE = 0.008); and for 45-year-olds (oldest participant) the corresponding slope was +0.011 (SE = 0.005). Fasting insulin level was negatively correlated with serum AMH. The regression slope for the correlation between 25OH-D and AMH in group 1 was +0.002 (SE = 0.006); in group 2 was +0.006 (SE = 0.005); and in group 3 was +0.011 (SE = 0.005). There was no association between HIV and AMH. Conclusion(s): A novel relationship is reported between circulating 25OH-D and AMH in women aged ≥40 years, suggesting that 25OH-D deficiency might be associated with lower ovarian reserve in late-reproductive-aged women.

Original languageEnglish (US)
Pages (from-to)228-234
Number of pages7
JournalFertility and Sterility
Volume98
Issue number1
DOIs
StatePublished - Jul 2012

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Vitamin D
HIV
Hormones
Serum
Insulin
Fasting
Glucose
Street Drugs
Menstrual Cycle
Glomerular Filtration Rate
Creatinine
Body Mass Index
Cross-Sectional Studies
Smoking
Outcome Assessment (Health Care)

Keywords

  • antimüllerian hormone
  • HIV
  • insulin resistance
  • müllerian-inhibiting substance
  • obesity
  • ovarian reserve
  • Vitamin D

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Circulating vitamin D correlates with serum antimüllerian hormone levels in late-reproductive-aged women : Women's Interagency HIV Study. / Merhi, Zaher O.; Seifer, David B.; Weedon, Jeremy; Adeyemi, Oluwatoyin; Holman, Susan; Anastos, Kathryn; Golub, Elizabeth T.; Young, Mary; Karim, Roksana; Greenblatt, Ruth; Minkoff, Howard.

In: Fertility and Sterility, Vol. 98, No. 1, 07.2012, p. 228-234.

Research output: Contribution to journalArticle

Merhi, ZO, Seifer, DB, Weedon, J, Adeyemi, O, Holman, S, Anastos, K, Golub, ET, Young, M, Karim, R, Greenblatt, R & Minkoff, H 2012, 'Circulating vitamin D correlates with serum antimüllerian hormone levels in late-reproductive-aged women: Women's Interagency HIV Study', Fertility and Sterility, vol. 98, no. 1, pp. 228-234. https://doi.org/10.1016/j.fertnstert.2012.03.029
Merhi, Zaher O. ; Seifer, David B. ; Weedon, Jeremy ; Adeyemi, Oluwatoyin ; Holman, Susan ; Anastos, Kathryn ; Golub, Elizabeth T. ; Young, Mary ; Karim, Roksana ; Greenblatt, Ruth ; Minkoff, Howard. / Circulating vitamin D correlates with serum antimüllerian hormone levels in late-reproductive-aged women : Women's Interagency HIV Study. In: Fertility and Sterility. 2012 ; Vol. 98, No. 1. pp. 228-234.
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abstract = "Objective: To study the correlation between circulating 25-hydroxyvitamin D (25OH-D) levels and serum antim{\"u}llerian hormone (AMH) in women enrolled in the Women's Interagency HIV Study. Design: Cross-sectional study. Setting: None. Patient(s): All premenopausal women (n = 388) with regular menstrual cycles were included and subdivided into three groups: group 1 with age <35 years (n = 128), group 2 with age 35-39 years (n = 119), and group 3 with age ≥40 years (n = 141). Intervention(s): Serum for 25OH-D, AMH, fasting glucose and insulin, and creatinine levels. Main Outcome Measure(s): Correlation between 25OH-D and AMH before and after adjusting for HIV status, body mass index, race, smoking, illicit drug use, glucose and insulin levels, estimated glomerular filtration rate, and geographic site of participation. Result(s): After adjusting for all covariates, the regression slope in all participants for total 25OH-D predicting log 10AMH for 25-year-olds (youngest participant) was -0.001 (SE = 0.008); and for 45-year-olds (oldest participant) the corresponding slope was +0.011 (SE = 0.005). Fasting insulin level was negatively correlated with serum AMH. The regression slope for the correlation between 25OH-D and AMH in group 1 was +0.002 (SE = 0.006); in group 2 was +0.006 (SE = 0.005); and in group 3 was +0.011 (SE = 0.005). There was no association between HIV and AMH. Conclusion(s): A novel relationship is reported between circulating 25OH-D and AMH in women aged ≥40 years, suggesting that 25OH-D deficiency might be associated with lower ovarian reserve in late-reproductive-aged women.",
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AU - Seifer, David B.

AU - Weedon, Jeremy

AU - Adeyemi, Oluwatoyin

AU - Holman, Susan

AU - Anastos, Kathryn

AU - Golub, Elizabeth T.

AU - Young, Mary

AU - Karim, Roksana

AU - Greenblatt, Ruth

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N2 - Objective: To study the correlation between circulating 25-hydroxyvitamin D (25OH-D) levels and serum antimüllerian hormone (AMH) in women enrolled in the Women's Interagency HIV Study. Design: Cross-sectional study. Setting: None. Patient(s): All premenopausal women (n = 388) with regular menstrual cycles were included and subdivided into three groups: group 1 with age <35 years (n = 128), group 2 with age 35-39 years (n = 119), and group 3 with age ≥40 years (n = 141). Intervention(s): Serum for 25OH-D, AMH, fasting glucose and insulin, and creatinine levels. Main Outcome Measure(s): Correlation between 25OH-D and AMH before and after adjusting for HIV status, body mass index, race, smoking, illicit drug use, glucose and insulin levels, estimated glomerular filtration rate, and geographic site of participation. Result(s): After adjusting for all covariates, the regression slope in all participants for total 25OH-D predicting log 10AMH for 25-year-olds (youngest participant) was -0.001 (SE = 0.008); and for 45-year-olds (oldest participant) the corresponding slope was +0.011 (SE = 0.005). Fasting insulin level was negatively correlated with serum AMH. The regression slope for the correlation between 25OH-D and AMH in group 1 was +0.002 (SE = 0.006); in group 2 was +0.006 (SE = 0.005); and in group 3 was +0.011 (SE = 0.005). There was no association between HIV and AMH. Conclusion(s): A novel relationship is reported between circulating 25OH-D and AMH in women aged ≥40 years, suggesting that 25OH-D deficiency might be associated with lower ovarian reserve in late-reproductive-aged women.

AB - Objective: To study the correlation between circulating 25-hydroxyvitamin D (25OH-D) levels and serum antimüllerian hormone (AMH) in women enrolled in the Women's Interagency HIV Study. Design: Cross-sectional study. Setting: None. Patient(s): All premenopausal women (n = 388) with regular menstrual cycles were included and subdivided into three groups: group 1 with age <35 years (n = 128), group 2 with age 35-39 years (n = 119), and group 3 with age ≥40 years (n = 141). Intervention(s): Serum for 25OH-D, AMH, fasting glucose and insulin, and creatinine levels. Main Outcome Measure(s): Correlation between 25OH-D and AMH before and after adjusting for HIV status, body mass index, race, smoking, illicit drug use, glucose and insulin levels, estimated glomerular filtration rate, and geographic site of participation. Result(s): After adjusting for all covariates, the regression slope in all participants for total 25OH-D predicting log 10AMH for 25-year-olds (youngest participant) was -0.001 (SE = 0.008); and for 45-year-olds (oldest participant) the corresponding slope was +0.011 (SE = 0.005). Fasting insulin level was negatively correlated with serum AMH. The regression slope for the correlation between 25OH-D and AMH in group 1 was +0.002 (SE = 0.006); in group 2 was +0.006 (SE = 0.005); and in group 3 was +0.011 (SE = 0.005). There was no association between HIV and AMH. Conclusion(s): A novel relationship is reported between circulating 25OH-D and AMH in women aged ≥40 years, suggesting that 25OH-D deficiency might be associated with lower ovarian reserve in late-reproductive-aged women.

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