Circulating thymulin and thymosin-α1 activity in pediatric acquired immune deficiency syndrome: In vivo and in vitro studies

Arye Rubinstein, Brian E. Novick, Marc J. Sicklick, Larry J. Bernstein, Genevieve S. Incefy, Paul H. Naylor, Allan L. Goldstein

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Twenty-five children with acquired immune deficiency syndrome (AIDS) or AIDS-related complex had a characteristic pattern of T cell deficiency. Abnormally low plasma thymulin levels preceded the development of peripheral blood T cell abnormalities. In contrast to patients with congenital T cell deficiencies, our patients had elevated serum levels of thymosin-α1. Treatment with thymosin fraction 5 in three children with AIDS resulted in only transient clinical and immunologic improvement.

Original languageEnglish (US)
Pages (from-to)422-427
Number of pages6
JournalThe Journal of Pediatrics
Volume109
Issue number3
DOIs
StatePublished - Sep 1986

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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