Twenty-five children with acquired immune deficiency syndrome (AIDS) or AIDS-related complex had a characteristic pattern of T cell deficiency. Abnormally low plasma thymulin levels preceded the development of peripheral blood T cell abnormalities. In contrast to patients with congenital T cell deficiencies, our patients had elevated serum levels of thymosin-α1. Treatment with thymosin fraction 5 in three children with AIDS resulted in only transient clinical and immunologic improvement.
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health