@article{a2c946725dd44a6ebce4b89a50b37aa9,
title = "Circulating thymulin and thymosin-α1 activity in pediatric acquired immune deficiency syndrome: In vivo and in vitro studies",
abstract = "Twenty-five children with acquired immune deficiency syndrome (AIDS) or AIDS-related complex had a characteristic pattern of T cell deficiency. Abnormally low plasma thymulin levels preceded the development of peripheral blood T cell abnormalities. In contrast to patients with congenital T cell deficiencies, our patients had elevated serum levels of thymosin-α1. Treatment with thymosin fraction 5 in three children with AIDS resulted in only transient clinical and immunologic improvement.",
author = "Arye Rubinstein and Novick, {Brian E.} and Sicklick, {Marc J.} and Bernstein, {Larry J.} and Incefy, {Genevieve S.} and Naylor, {Paul H.} and Goldstein, {Allan L.}",
note = "Funding Information: Supported by Grants AI 20671 (A.R.), CA 33168, and CA 33050 (G.S.I.) from the National Cancer Institute, and by a grant from March of Dimes Birth Defects Foundation (A.R.). Submitted for publication Sept. 6, 1985; accepted March 24, 1986. Reprint requests: Arye Rubinstein, M.D., Department of Pediatrics, Microbiology and Immunology, Albert Einstein College of Medicine, Forchheimer Building, Rm. F 426, 1300 Morris Park Ave., Bronx, NY 10461.",
year = "1986",
month = sep,
doi = "10.1016/S0022-3476(86)80111-1",
language = "English (US)",
volume = "109",
pages = "422--427",
journal = "The Journal of Pediatrics",
issn = "0022-3476",
publisher = "Mosby Inc.",
number = "3",
}
