Circulating sex hormones and breast cancer risk factors in postmenopausal women: Reanalysis of 13 studies

T. J. Key, P. N. Appleby, G. K. Reeves, A. W. Roddam, K. J. Helzlsouer, A. J. Alberg, D. E. Rollison, J. F. Dorgan, L. A. Brinton, K. Overvad, R. Kaaks, A. Trichopoulou, F. Clavel-Chapelon, S. Panico, E. J. Duell, P. H M Peeters, S. Rinaldi, I. S. Fentiman, M. Dowsett, J. ManjerP. Lenner, G. Hallmans, L. Baglietto, D. R. English, G. G. Giles, J. L. Hopper, G. Severi, H. A. Morris, S. E. Hankinson, S. S. Tworoger, K. Koenig, A. Zeleniuch-Jacquotte, A. A. Arslan, P. Toniolo, R. E. Shore, V. Krogh, A. Micheli, F. Berrino, E. Barrett-Connor, G. A. Laughlin, M. Kabuto, S. Akiba, R. G. Stevens, K. Neriishi, C. E. Land, J. A. Cauley, L. Y. Lui, S. R. Cummings, M. J. Gunter, Thomas E. Rohan, Howard Strickler

Research output: Contribution to journalArticle

217 Citations (Scopus)

Abstract

Background: Breast cancer risk for postmenopausal women is positively associated with circulating concentrations of oestrogens and androgens, but the determinants of these hormones are not well understood. Methods: Cross-sectional analyses of breast cancer risk factors and circulating hormone concentrations in more than 6000 postmenopausal women controls in 13 prospective studies. Results: Concentrations of all hormones were lower in older than younger women, with the largest difference for dehydroepiandrosterone sulphate (DHEAS), whereas sex hormone-binding globulin (SHBG) was higher in the older women. Androgens were lower in women with bilateral ovariectomy than in naturally postmenopausal women, with the largest difference for free testosterone. All hormones were higher in obese than lean women, with the largest difference for free oestradiol, whereas SHBG was lower in obese women. Smokers of 15 cigarettes per day had higher levels of all hormones than non-smokers, with the largest difference for testosterone. Drinkers of 20 g alcohol per day had higher levels of all hormones, but lower SHBG, than non-drinkers, with the largest difference for DHEAS. Hormone concentrations were not strongly related to age at menarche, parity, age at first full-term pregnancy or family history of breast cancer.Conclusion:Sex hormone concentrations were strongly associated with several established or suspected risk factors for breast cancer, and may mediate the effects of these factors on breast cancer risk.

Original languageEnglish (US)
Pages (from-to)709-722
Number of pages14
JournalBritish Journal of Cancer
Volume105
Issue number5
DOIs
StatePublished - Aug 23 2011

Fingerprint

Gonadal Steroid Hormones
Breast Neoplasms
Hormones
Sex Hormone-Binding Globulin
Dehydroepiandrosterone Sulfate
Androgens
Testosterone
Menarche
Ovariectomy
Parity
Tobacco Products
Estradiol
Estrogens
Cross-Sectional Studies
Alcohols
Prospective Studies
Pregnancy

Keywords

  • androgens
  • breast cancer
  • hormones
  • oestrogens
  • sex hormone-binding globulin

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Circulating sex hormones and breast cancer risk factors in postmenopausal women : Reanalysis of 13 studies. / Key, T. J.; Appleby, P. N.; Reeves, G. K.; Roddam, A. W.; Helzlsouer, K. J.; Alberg, A. J.; Rollison, D. E.; Dorgan, J. F.; Brinton, L. A.; Overvad, K.; Kaaks, R.; Trichopoulou, A.; Clavel-Chapelon, F.; Panico, S.; Duell, E. J.; Peeters, P. H M; Rinaldi, S.; Fentiman, I. S.; Dowsett, M.; Manjer, J.; Lenner, P.; Hallmans, G.; Baglietto, L.; English, D. R.; Giles, G. G.; Hopper, J. L.; Severi, G.; Morris, H. A.; Hankinson, S. E.; Tworoger, S. S.; Koenig, K.; Zeleniuch-Jacquotte, A.; Arslan, A. A.; Toniolo, P.; Shore, R. E.; Krogh, V.; Micheli, A.; Berrino, F.; Barrett-Connor, E.; Laughlin, G. A.; Kabuto, M.; Akiba, S.; Stevens, R. G.; Neriishi, K.; Land, C. E.; Cauley, J. A.; Lui, L. Y.; Cummings, S. R.; Gunter, M. J.; Rohan, Thomas E.; Strickler, Howard.

In: British Journal of Cancer, Vol. 105, No. 5, 23.08.2011, p. 709-722.

Research output: Contribution to journalArticle

Key, TJ, Appleby, PN, Reeves, GK, Roddam, AW, Helzlsouer, KJ, Alberg, AJ, Rollison, DE, Dorgan, JF, Brinton, LA, Overvad, K, Kaaks, R, Trichopoulou, A, Clavel-Chapelon, F, Panico, S, Duell, EJ, Peeters, PHM, Rinaldi, S, Fentiman, IS, Dowsett, M, Manjer, J, Lenner, P, Hallmans, G, Baglietto, L, English, DR, Giles, GG, Hopper, JL, Severi, G, Morris, HA, Hankinson, SE, Tworoger, SS, Koenig, K, Zeleniuch-Jacquotte, A, Arslan, AA, Toniolo, P, Shore, RE, Krogh, V, Micheli, A, Berrino, F, Barrett-Connor, E, Laughlin, GA, Kabuto, M, Akiba, S, Stevens, RG, Neriishi, K, Land, CE, Cauley, JA, Lui, LY, Cummings, SR, Gunter, MJ, Rohan, TE & Strickler, H 2011, 'Circulating sex hormones and breast cancer risk factors in postmenopausal women: Reanalysis of 13 studies', British Journal of Cancer, vol. 105, no. 5, pp. 709-722. https://doi.org/10.1038/bjc.2011.254
Key, T. J. ; Appleby, P. N. ; Reeves, G. K. ; Roddam, A. W. ; Helzlsouer, K. J. ; Alberg, A. J. ; Rollison, D. E. ; Dorgan, J. F. ; Brinton, L. A. ; Overvad, K. ; Kaaks, R. ; Trichopoulou, A. ; Clavel-Chapelon, F. ; Panico, S. ; Duell, E. J. ; Peeters, P. H M ; Rinaldi, S. ; Fentiman, I. S. ; Dowsett, M. ; Manjer, J. ; Lenner, P. ; Hallmans, G. ; Baglietto, L. ; English, D. R. ; Giles, G. G. ; Hopper, J. L. ; Severi, G. ; Morris, H. A. ; Hankinson, S. E. ; Tworoger, S. S. ; Koenig, K. ; Zeleniuch-Jacquotte, A. ; Arslan, A. A. ; Toniolo, P. ; Shore, R. E. ; Krogh, V. ; Micheli, A. ; Berrino, F. ; Barrett-Connor, E. ; Laughlin, G. A. ; Kabuto, M. ; Akiba, S. ; Stevens, R. G. ; Neriishi, K. ; Land, C. E. ; Cauley, J. A. ; Lui, L. Y. ; Cummings, S. R. ; Gunter, M. J. ; Rohan, Thomas E. ; Strickler, Howard. / Circulating sex hormones and breast cancer risk factors in postmenopausal women : Reanalysis of 13 studies. In: British Journal of Cancer. 2011 ; Vol. 105, No. 5. pp. 709-722.
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abstract = "Background: Breast cancer risk for postmenopausal women is positively associated with circulating concentrations of oestrogens and androgens, but the determinants of these hormones are not well understood. Methods: Cross-sectional analyses of breast cancer risk factors and circulating hormone concentrations in more than 6000 postmenopausal women controls in 13 prospective studies. Results: Concentrations of all hormones were lower in older than younger women, with the largest difference for dehydroepiandrosterone sulphate (DHEAS), whereas sex hormone-binding globulin (SHBG) was higher in the older women. Androgens were lower in women with bilateral ovariectomy than in naturally postmenopausal women, with the largest difference for free testosterone. All hormones were higher in obese than lean women, with the largest difference for free oestradiol, whereas SHBG was lower in obese women. Smokers of 15 cigarettes per day had higher levels of all hormones than non-smokers, with the largest difference for testosterone. Drinkers of 20 g alcohol per day had higher levels of all hormones, but lower SHBG, than non-drinkers, with the largest difference for DHEAS. Hormone concentrations were not strongly related to age at menarche, parity, age at first full-term pregnancy or family history of breast cancer.Conclusion:Sex hormone concentrations were strongly associated with several established or suspected risk factors for breast cancer, and may mediate the effects of these factors on breast cancer risk.",
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T1 - Circulating sex hormones and breast cancer risk factors in postmenopausal women

T2 - Reanalysis of 13 studies

AU - Key, T. J.

AU - Appleby, P. N.

AU - Reeves, G. K.

AU - Roddam, A. W.

AU - Helzlsouer, K. J.

AU - Alberg, A. J.

AU - Rollison, D. E.

AU - Dorgan, J. F.

AU - Brinton, L. A.

AU - Overvad, K.

AU - Kaaks, R.

AU - Trichopoulou, A.

AU - Clavel-Chapelon, F.

AU - Panico, S.

AU - Duell, E. J.

AU - Peeters, P. H M

AU - Rinaldi, S.

AU - Fentiman, I. S.

AU - Dowsett, M.

AU - Manjer, J.

AU - Lenner, P.

AU - Hallmans, G.

AU - Baglietto, L.

AU - English, D. R.

AU - Giles, G. G.

AU - Hopper, J. L.

AU - Severi, G.

AU - Morris, H. A.

AU - Hankinson, S. E.

AU - Tworoger, S. S.

AU - Koenig, K.

AU - Zeleniuch-Jacquotte, A.

AU - Arslan, A. A.

AU - Toniolo, P.

AU - Shore, R. E.

AU - Krogh, V.

AU - Micheli, A.

AU - Berrino, F.

AU - Barrett-Connor, E.

AU - Laughlin, G. A.

AU - Kabuto, M.

AU - Akiba, S.

AU - Stevens, R. G.

AU - Neriishi, K.

AU - Land, C. E.

AU - Cauley, J. A.

AU - Lui, L. Y.

AU - Cummings, S. R.

AU - Gunter, M. J.

AU - Rohan, Thomas E.

AU - Strickler, Howard

PY - 2011/8/23

Y1 - 2011/8/23

N2 - Background: Breast cancer risk for postmenopausal women is positively associated with circulating concentrations of oestrogens and androgens, but the determinants of these hormones are not well understood. Methods: Cross-sectional analyses of breast cancer risk factors and circulating hormone concentrations in more than 6000 postmenopausal women controls in 13 prospective studies. Results: Concentrations of all hormones were lower in older than younger women, with the largest difference for dehydroepiandrosterone sulphate (DHEAS), whereas sex hormone-binding globulin (SHBG) was higher in the older women. Androgens were lower in women with bilateral ovariectomy than in naturally postmenopausal women, with the largest difference for free testosterone. All hormones were higher in obese than lean women, with the largest difference for free oestradiol, whereas SHBG was lower in obese women. Smokers of 15 cigarettes per day had higher levels of all hormones than non-smokers, with the largest difference for testosterone. Drinkers of 20 g alcohol per day had higher levels of all hormones, but lower SHBG, than non-drinkers, with the largest difference for DHEAS. Hormone concentrations were not strongly related to age at menarche, parity, age at first full-term pregnancy or family history of breast cancer.Conclusion:Sex hormone concentrations were strongly associated with several established or suspected risk factors for breast cancer, and may mediate the effects of these factors on breast cancer risk.

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KW - androgens

KW - breast cancer

KW - hormones

KW - oestrogens

KW - sex hormone-binding globulin

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