Circulating miRNAs in Ageing and Ageing-Related Diseases

Hwa Jin Jung, Yousin Suh

Research output: Contribution to journalReview articlepeer-review

60 Scopus citations

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. They are involved in important biological processes including development, homeostasis, and ageing. Recently, extracellular miRNAs have been discovered in the bloodstream and bodily fluids. These miRNAs are shown to be secreted and circulating in microvesicles (MVs), or in complex with other factors such as RNA-binding proteins and high-density lipoprotein (HDL) particles. These cell-free, circulating miRNAs can be taken into and function as negative regulators of target genes in recipient cells. Here we review the biogenesis and uptake of circulating miRNAs as well as their profiles in ageing and ageing-related diseases. We discuss the emerging role of circulating miRNAs as biomarkers and therapeutic targets.

Original languageEnglish (US)
Pages (from-to)465-472
Number of pages8
JournalJournal of Genetics and Genomics
Volume41
Issue number9
DOIs
StatePublished - Sep 20 2014

Keywords

  • Ageing
  • Ageing-related disease
  • Biomarkers
  • Circulating miRNAs

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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