Circulating levels of colony-stimulating factor 1 as a prognostic indicator in 82 patients with epithelial ovarian cancer

S. M. Scholl, C. H. Bascou, V. Mosseri, R. Olivares, H. Magdelenat, T. Dorval, T. Palangié, P. Validire, P. Pouillart, E. R. Stanley

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Abstract

Serum samples from 82 patients with epithelial ovarian cancer, previously assayed for CA125, were assayed for circulating colony-stimulating factor 1 (CSF-1). An elevated CSF-1 concentration (> 450 U ml-1 or > 5.42 ng ml-1) was significantly associated with a worse survival (P = 0.02). The predictive value of raised CSF-1 levels was retained whether the first available sample for all patients (n = 82) or the first sample at the start of chemotherapy (n = 41) was considered. Mean CSF-1 levels (n = 14) dropped significantly during six courses of platinum-based chemotherapy (P = 0.02). Although an elevated CA125 concentration appeared to be a prognostic indicator in the total population (n = 82), it was not related to prognosis in the group of patients from whom samples had been drawn at the start of chemotherapy. In a Cox proportional hazards model, CSF-1, but not CA125, was significantly associated with outcome following adjustment for stage, grade and degree of surgical clearance.

Original languageEnglish (US)
Pages (from-to)342-346
Number of pages5
JournalBritish Journal of Cancer
Volume69
Issue number2
DOIs
Publication statusPublished - Feb 1994

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Scholl, S. M., Bascou, C. H., Mosseri, V., Olivares, R., Magdelenat, H., Dorval, T., ... Stanley, E. R. (1994). Circulating levels of colony-stimulating factor 1 as a prognostic indicator in 82 patients with epithelial ovarian cancer. British Journal of Cancer, 69(2), 342-346. https://doi.org/10.1038/bjc.1994.62