TY - JOUR
T1 - Circadian variations in serum zinc (Zn) concentrations
T2 - Correlation with blood ionized calcium, serum total calcium and phosphate in humans
AU - Markowitz, M. E.
AU - Rosen, J. F.
AU - Mizruchi, M.
PY - 1985
Y1 - 1985
N2 - Serum zinc (Zn) concentrations were determined in sequentially drawn blood samples from six healthy adult males. Each subject had blood sampling performed every 30 minutes for 24 hours. Mean Zn concentrations at each time point (n = 6, 48 time points) were plotted and fitted by a polynomial regression of the data against time. A 'U' shaped curve was derived; we found peak Zn levels at 9:30 AM, a midtrough at 8 PM and a peak-trough difference of 19 μg/dl. Correlation with a similarly derived 24-h ionized calcium pattern was strikingly high, r = .923, p < .001. An intermediate correlation between the Zn and phosphate patterns was observed, r = -.493, p < .01; and no significant correlation occurred between Zn and total calcium rhythms, r = .167. These data conclusively demonstrate the presence of a circadian rhythm in serum Zn in healthy adult males. Furthermore, the high correlation between the Zn and ionized calcium patterns suggests a common regulator.
AB - Serum zinc (Zn) concentrations were determined in sequentially drawn blood samples from six healthy adult males. Each subject had blood sampling performed every 30 minutes for 24 hours. Mean Zn concentrations at each time point (n = 6, 48 time points) were plotted and fitted by a polynomial regression of the data against time. A 'U' shaped curve was derived; we found peak Zn levels at 9:30 AM, a midtrough at 8 PM and a peak-trough difference of 19 μg/dl. Correlation with a similarly derived 24-h ionized calcium pattern was strikingly high, r = .923, p < .001. An intermediate correlation between the Zn and phosphate patterns was observed, r = -.493, p < .01; and no significant correlation occurred between Zn and total calcium rhythms, r = .167. These data conclusively demonstrate the presence of a circadian rhythm in serum Zn in healthy adult males. Furthermore, the high correlation between the Zn and ionized calcium patterns suggests a common regulator.
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U2 - 10.1093/ajcn/41.4.689
DO - 10.1093/ajcn/41.4.689
M3 - Article
C2 - 3984922
AN - SCOPUS:0021923314
SN - 0002-9165
VL - 41
SP - 689
EP - 696
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
IS - 4
ER -