Circadian variation in the frequency of myocardial infarction and death associated with acute pulmonary edema

David Barash, Robert A. Silverman, Paul Gennis, Nancy Budner, Marshall Matos, E. John Gallagher

Research output: Contribution to journalArticle

15 Scopus citations


The records of 103 patients hospitalized for acute pulmonary edema were reviewed to determine the relationship between short-term outcome and time of presentation to the emergency department. Although only 17% of the patients arrived in the emergency department during the early afternoon hours, half of the deaths in the study occurred in this group. Patients presenting between noon and four PM had a significantly higher incidence of acute myocardial infarction (76% v. 28%, p=0.03) and death (47% v. 9% p=0.03) compared with patients presenting at other times. Differences in the pathophysiology of daytime versus nocturnal acute pulmonary edema may account for some of the variation in outcome.

Original languageEnglish (US)
Pages (from-to)119-121
Number of pages3
JournalJournal of Emergency Medicine
Issue number2
StatePublished - Jan 1 1989



  • acute pulmonary edema
  • circadian variation
  • myocardial infarction

ASJC Scopus subject areas

  • Emergency Medicine

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