Circadian rhythms of blood minerals during adolescence

Morri E. Markowitz, John F. Rosen, Swamy Laxminarayan, Mark Mizruchi

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16 Scopus citations


Sequential blood sampling every 30 min was performed in six adolescent males. Samples were analyzed for serum phosphate ((Pi) total calcium (CaT) and blood ionized calcium (Ca++) concentrations. A circadian (24-h) pattern was observed for each mineral 1) Ca++ concentrations followed a U-shaped curve with a peak at 11 AM and a trough at 3:30 PM; 2) CaT concentrations followed a W-shaped curve with maxima at 11 and 1 AM and troughs at 5 AM and 6 PM and 3) Pi concentrations followed an M-shaped curve with peaks at 4 PM and 3:30 AM. The overall mineral patterns were similar in shape to those previously decribed in adult males. In contrast however the amplitude of the Pi fluctuations were considerably greater in the adolescents compared with that in adults (3.0 mg/dl versus 1.2 mg/dl). The Ca++ pattern diverged from the CaT pattern during the nocturnal phase to an extent that neither pattern could be predicted from the other. Ultradian rhythms were found in some of the time series mineral data sets however no single frequency encompassed all subjects for each circulating mineral.

Original languageEnglish (US)
Pages (from-to)456-462
Number of pages7
JournalPediatric Research
Issue number5
StatePublished - May 1984

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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