Circadian rhythm profiles in women with night eating syndrome

Namni Goel, Albert J. Stunkard, Naomi L. Rogers, Hans P A Van Dongen, Kelly C. Allison, John P. O'Reardon, Rexford S. Ahima, David E. Cummings, Moonseong Heo, David F. Dinges

Research output: Contribution to journalArticle

113 Citations (Scopus)

Abstract

Night eating syndrome (NES) is characterized by evening hyperphagia and frequent awakenings accompanied by food intake. Patients with NES display a delayed circadian pattern of food intake but retain a normal sleep-wake cycle. These characteristics initiated the current study, in which the phase and amplitude of behavioral and neuroendocrine circadian rhythms in patients with NES were evaluated. Fifteen women with NES (mean age ± SD, 40.8 ± 8.7 y) and 14 control subjects (38.6 ± 9.5 y) were studied in the laboratory for 3 nights, with food intake measured daily. Blood also was collected for 25 h (every 2 h from 0800 to 2000 h, and then hourly from 2100 to 0900 h) and assayed for glucose and 7 hormones (insulin, ghrelin, leptin, melatonin, cortisol, thyroid-stimulating hormone [TSH] and prolactin). Statistical analyses utilized linear mixed-effects cosinor analysis. Control subjects displayed normal phases and amplitudes for all circadian rhythms. In contrast, patients with NES showed a phase delay in the timing of meals, and delayed circadian rhythms for total caloric, fat, and carbohydrate intake. In addition, phase delays of 1.0 to 2.8 h were found in 2 food-regulatory rhythms-leptin and insulin-and in the circadian melatonin rhythm (with a trend for a delay in the circadian cortisol rhythm). In contrast, circulating levels of ghrelin, the primary hormone that stimulates food intake, were phase advanced by 5.2 h. The glucose rhythm showed an inverted circadian pattern. Patients with NES also showed reduced amplitudes in the circadian rhythms of food intake, cortisol, ghrelin, and insulin, but increased TSH amplitude. Thus, patients with NES demonstrated significant changes in the timing and amplitude of various behavioral and physiological circadian markers involved in appetite and neuroendocrine regulation. As such, NES may result from dissociations between central (suprachiasmatic nucleus) timing mechanisms and putative oscillators elsewhere in the central nervous system or periphery, such as the stomach or liver. Considering these results, chronobiologic treatments for NES such as bright light therapy may be useful. Indeed, bright light therapy has shown efficacy in reducing night eating in case studies and should be evaluated in controlled clinical trials.

Original languageEnglish (US)
Pages (from-to)85-94
Number of pages10
JournalJournal of Biological Rhythms
Volume24
Issue number1
DOIs
StatePublished - Feb 2009

Fingerprint

Circadian Rhythm
Eating
Ghrelin
Hydrocortisone
Phototherapy
Thyrotropin
Melatonin
Insulin
Leptin
Hormones
Appetite Regulation
Glucose
Hyperphagia
Suprachiasmatic Nucleus
Controlled Clinical Trials
Prolactin
Meals
Stomach
Sleep
Central Nervous System

Keywords

  • Amplitude
  • Circadian rhythms
  • Mixed-effects cosinor analysis
  • Night eating syndrome
  • Phase shifts

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Goel, N., Stunkard, A. J., Rogers, N. L., Van Dongen, H. P. A., Allison, K. C., O'Reardon, J. P., ... Dinges, D. F. (2009). Circadian rhythm profiles in women with night eating syndrome. Journal of Biological Rhythms, 24(1), 85-94. https://doi.org/10.1177/0748730408328914

Circadian rhythm profiles in women with night eating syndrome. / Goel, Namni; Stunkard, Albert J.; Rogers, Naomi L.; Van Dongen, Hans P A; Allison, Kelly C.; O'Reardon, John P.; Ahima, Rexford S.; Cummings, David E.; Heo, Moonseong; Dinges, David F.

In: Journal of Biological Rhythms, Vol. 24, No. 1, 02.2009, p. 85-94.

Research output: Contribution to journalArticle

Goel, N, Stunkard, AJ, Rogers, NL, Van Dongen, HPA, Allison, KC, O'Reardon, JP, Ahima, RS, Cummings, DE, Heo, M & Dinges, DF 2009, 'Circadian rhythm profiles in women with night eating syndrome', Journal of Biological Rhythms, vol. 24, no. 1, pp. 85-94. https://doi.org/10.1177/0748730408328914
Goel N, Stunkard AJ, Rogers NL, Van Dongen HPA, Allison KC, O'Reardon JP et al. Circadian rhythm profiles in women with night eating syndrome. Journal of Biological Rhythms. 2009 Feb;24(1):85-94. https://doi.org/10.1177/0748730408328914
Goel, Namni ; Stunkard, Albert J. ; Rogers, Naomi L. ; Van Dongen, Hans P A ; Allison, Kelly C. ; O'Reardon, John P. ; Ahima, Rexford S. ; Cummings, David E. ; Heo, Moonseong ; Dinges, David F. / Circadian rhythm profiles in women with night eating syndrome. In: Journal of Biological Rhythms. 2009 ; Vol. 24, No. 1. pp. 85-94.
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