Cigarette smoking and risk of prostate cancer: A population-based case- control study in Ontario and British Columbia, Canada

Thomas E. Rohan, T. G. Hislop, G. R. Howe, R. P. Gallagher, C. Z. Teh, P. Ghadirian

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The relationship between cigarette smoking and risk of prostate cancer was examined in a case-control study conducted in Ontario and British Columbia, Canada. In each centre, cases were men with a histologically confirmed diagnosis of adenocarcinoma of the prostate notified to the provincial cancer registry. In Ontario, controls were selected randomly from assessment fists maintained by the Ontario Ministry of Revenue and were frequency matched to the cases on age. In British Columbia, controls were also frequency matched to the cases on age and were selected randomly from a roster maintained by the Medical Services Plan of British Columbia. The study in Ontario was conducted between April 1990 and April 1992, and that in British Columbia was conducted between January 1989 and December 1991. In all, the study included 408 cases (207 in Ontario and 201 in British Columbia) and 407 controls (207 in Toronto and 200 in British Columbia (one case was unmatched)). Overall, there was little variation in risk of prostate cancer with pack-years of cigarette consumption (filter and non-filter cigarettes combined), and there was no evidence for an effect confined to filter or non-filter cigarettes. There was some evidence for a positive association with non-filter cigarettes in British Columbia, but on formal testing for heterogeneity, this finding was not inconsistent with the absence of an association in Ontario. There was also little variation in risk by years since first smoked or (for ex-smokers) by years since quitting. These data provide little support for an association between cigarette smoking and prostate cancer risk.

Original languageEnglish (US)
Pages (from-to)382-388
Number of pages7
JournalEuropean Journal of Cancer Prevention
Volume6
Issue number4
DOIs
StatePublished - 1997
Externally publishedYes

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British Columbia
Ontario
Canada
Case-Control Studies
Prostatic Neoplasms
Smoking
Tobacco Products
Population
Registries
Prostate
Adenocarcinoma

Keywords

  • Cigarette smoking
  • Prostate cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Cigarette smoking and risk of prostate cancer : A population-based case- control study in Ontario and British Columbia, Canada. / Rohan, Thomas E.; Hislop, T. G.; Howe, G. R.; Gallagher, R. P.; Teh, C. Z.; Ghadirian, P.

In: European Journal of Cancer Prevention, Vol. 6, No. 4, 1997, p. 382-388.

Research output: Contribution to journalArticle

Rohan, Thomas E. ; Hislop, T. G. ; Howe, G. R. ; Gallagher, R. P. ; Teh, C. Z. ; Ghadirian, P. / Cigarette smoking and risk of prostate cancer : A population-based case- control study in Ontario and British Columbia, Canada. In: European Journal of Cancer Prevention. 1997 ; Vol. 6, No. 4. pp. 382-388.
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