Cigarette smoking and incident heart failure: Insights from the jackson heart study

Daisuke Kamimura, Loretta R. Cain, Robert J. Mentz, Wendy B. White, Michael J. Blaha, Andrew P. Defilippis, Ervin R. Fox, Carlos J. Rodriguez, Rachel J. Keith, Emelia J. Benjamin, Javed Butler, Aruni Bhatnagar, Rose M. Robertson, Michael D. Winniford, Adolfo Correa, Michael E. Hall

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Cigarette smoking has been linked with several factors associated with cardiac dysfunction. We hypothesized that cigarette smoking is associated with left ventricular (LV) structure and function, and incident heart failure (HF) hospitalization. Methods: We investigated 4129 (never smoker n=2884, current smoker n=503, and former smoker n=742) black participants (mean age, 54 years; 63% women) without a history of HF or coronary heart disease at baseline in the Jackson Heart Study. We examined the relationships between cigarette smoking and LV structure and function by using cardiac magnetic resonance imaging among 1092 participants, cigarette smoking and brain natriuretic peptide levels among 3325 participants, and incident HF hospitalization among 3633 participants with complete data. Results: After adjustment for confounding factors, current smoking was associated with higher mean LV mass index and lower mean LV circumferential strain (P<0.05, for both) in comparison with never smoking. Smoking status, intensity, and burden were associated with higher mean brain natriuretic peptide levels (all P<0.05). Over 8.0 years (7.7-8.0) median follow-up, there were 147 incident HF hospitalizations. After adjustment for traditional risk factors and incident coronary heart disease, current smoking (hazard ratio, 2.82; 95% confidence interval, 1.71-4.64), smoking intensity among current smokers (≥20 cigarettes/d: hazard ratio, 3.48; 95% confidence interval, 1.65-7.32), and smoking burden among ever smokers (≥15 pack-years: hazard ratio, 2.06; 95% confidence interval, 1.29-3.3) were significantly associated with incident HF hospitalization in comparison with never smoking. Conclusions: In blacks, cigarette smoking is an important risk factor for LV hypertrophy, systolic dysfunction, and incident HF hospitalization even after adjusting for effects on coronary heart disease.

Original languageEnglish (US)
Pages (from-to)2572-2582
Number of pages11
JournalCirculation
Volume137
Issue number24
DOIs
StatePublished - Jun 12 2018
Externally publishedYes

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Heart Failure
Smoking
Hospitalization
Coronary Disease
Brain Natriuretic Peptide
Confidence Intervals
Left Ventricular Function
Left Ventricular Hypertrophy
Tobacco Products
Magnetic Resonance Imaging

Keywords

  • African Continental Ancestry Group
  • cardiac imaging techniques
  • coronary disease
  • heart failure
  • smoking

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Kamimura, D., Cain, L. R., Mentz, R. J., White, W. B., Blaha, M. J., Defilippis, A. P., ... Hall, M. E. (2018). Cigarette smoking and incident heart failure: Insights from the jackson heart study. Circulation, 137(24), 2572-2582. https://doi.org/10.1161/CIRCULATIONAHA.117.031912

Cigarette smoking and incident heart failure : Insights from the jackson heart study. / Kamimura, Daisuke; Cain, Loretta R.; Mentz, Robert J.; White, Wendy B.; Blaha, Michael J.; Defilippis, Andrew P.; Fox, Ervin R.; Rodriguez, Carlos J.; Keith, Rachel J.; Benjamin, Emelia J.; Butler, Javed; Bhatnagar, Aruni; Robertson, Rose M.; Winniford, Michael D.; Correa, Adolfo; Hall, Michael E.

In: Circulation, Vol. 137, No. 24, 12.06.2018, p. 2572-2582.

Research output: Contribution to journalArticle

Kamimura, D, Cain, LR, Mentz, RJ, White, WB, Blaha, MJ, Defilippis, AP, Fox, ER, Rodriguez, CJ, Keith, RJ, Benjamin, EJ, Butler, J, Bhatnagar, A, Robertson, RM, Winniford, MD, Correa, A & Hall, ME 2018, 'Cigarette smoking and incident heart failure: Insights from the jackson heart study', Circulation, vol. 137, no. 24, pp. 2572-2582. https://doi.org/10.1161/CIRCULATIONAHA.117.031912
Kamimura D, Cain LR, Mentz RJ, White WB, Blaha MJ, Defilippis AP et al. Cigarette smoking and incident heart failure: Insights from the jackson heart study. Circulation. 2018 Jun 12;137(24):2572-2582. https://doi.org/10.1161/CIRCULATIONAHA.117.031912
Kamimura, Daisuke ; Cain, Loretta R. ; Mentz, Robert J. ; White, Wendy B. ; Blaha, Michael J. ; Defilippis, Andrew P. ; Fox, Ervin R. ; Rodriguez, Carlos J. ; Keith, Rachel J. ; Benjamin, Emelia J. ; Butler, Javed ; Bhatnagar, Aruni ; Robertson, Rose M. ; Winniford, Michael D. ; Correa, Adolfo ; Hall, Michael E. / Cigarette smoking and incident heart failure : Insights from the jackson heart study. In: Circulation. 2018 ; Vol. 137, No. 24. pp. 2572-2582.
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abstract = "Background: Cigarette smoking has been linked with several factors associated with cardiac dysfunction. We hypothesized that cigarette smoking is associated with left ventricular (LV) structure and function, and incident heart failure (HF) hospitalization. Methods: We investigated 4129 (never smoker n=2884, current smoker n=503, and former smoker n=742) black participants (mean age, 54 years; 63{\%} women) without a history of HF or coronary heart disease at baseline in the Jackson Heart Study. We examined the relationships between cigarette smoking and LV structure and function by using cardiac magnetic resonance imaging among 1092 participants, cigarette smoking and brain natriuretic peptide levels among 3325 participants, and incident HF hospitalization among 3633 participants with complete data. Results: After adjustment for confounding factors, current smoking was associated with higher mean LV mass index and lower mean LV circumferential strain (P<0.05, for both) in comparison with never smoking. Smoking status, intensity, and burden were associated with higher mean brain natriuretic peptide levels (all P<0.05). Over 8.0 years (7.7-8.0) median follow-up, there were 147 incident HF hospitalizations. After adjustment for traditional risk factors and incident coronary heart disease, current smoking (hazard ratio, 2.82; 95{\%} confidence interval, 1.71-4.64), smoking intensity among current smokers (≥20 cigarettes/d: hazard ratio, 3.48; 95{\%} confidence interval, 1.65-7.32), and smoking burden among ever smokers (≥15 pack-years: hazard ratio, 2.06; 95{\%} confidence interval, 1.29-3.3) were significantly associated with incident HF hospitalization in comparison with never smoking. Conclusions: In blacks, cigarette smoking is an important risk factor for LV hypertrophy, systolic dysfunction, and incident HF hospitalization even after adjusting for effects on coronary heart disease.",
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T2 - Insights from the jackson heart study

AU - Kamimura, Daisuke

AU - Cain, Loretta R.

AU - Mentz, Robert J.

AU - White, Wendy B.

AU - Blaha, Michael J.

AU - Defilippis, Andrew P.

AU - Fox, Ervin R.

AU - Rodriguez, Carlos J.

AU - Keith, Rachel J.

AU - Benjamin, Emelia J.

AU - Butler, Javed

AU - Bhatnagar, Aruni

AU - Robertson, Rose M.

AU - Winniford, Michael D.

AU - Correa, Adolfo

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N2 - Background: Cigarette smoking has been linked with several factors associated with cardiac dysfunction. We hypothesized that cigarette smoking is associated with left ventricular (LV) structure and function, and incident heart failure (HF) hospitalization. Methods: We investigated 4129 (never smoker n=2884, current smoker n=503, and former smoker n=742) black participants (mean age, 54 years; 63% women) without a history of HF or coronary heart disease at baseline in the Jackson Heart Study. We examined the relationships between cigarette smoking and LV structure and function by using cardiac magnetic resonance imaging among 1092 participants, cigarette smoking and brain natriuretic peptide levels among 3325 participants, and incident HF hospitalization among 3633 participants with complete data. Results: After adjustment for confounding factors, current smoking was associated with higher mean LV mass index and lower mean LV circumferential strain (P<0.05, for both) in comparison with never smoking. Smoking status, intensity, and burden were associated with higher mean brain natriuretic peptide levels (all P<0.05). Over 8.0 years (7.7-8.0) median follow-up, there were 147 incident HF hospitalizations. After adjustment for traditional risk factors and incident coronary heart disease, current smoking (hazard ratio, 2.82; 95% confidence interval, 1.71-4.64), smoking intensity among current smokers (≥20 cigarettes/d: hazard ratio, 3.48; 95% confidence interval, 1.65-7.32), and smoking burden among ever smokers (≥15 pack-years: hazard ratio, 2.06; 95% confidence interval, 1.29-3.3) were significantly associated with incident HF hospitalization in comparison with never smoking. Conclusions: In blacks, cigarette smoking is an important risk factor for LV hypertrophy, systolic dysfunction, and incident HF hospitalization even after adjusting for effects on coronary heart disease.

AB - Background: Cigarette smoking has been linked with several factors associated with cardiac dysfunction. We hypothesized that cigarette smoking is associated with left ventricular (LV) structure and function, and incident heart failure (HF) hospitalization. Methods: We investigated 4129 (never smoker n=2884, current smoker n=503, and former smoker n=742) black participants (mean age, 54 years; 63% women) without a history of HF or coronary heart disease at baseline in the Jackson Heart Study. We examined the relationships between cigarette smoking and LV structure and function by using cardiac magnetic resonance imaging among 1092 participants, cigarette smoking and brain natriuretic peptide levels among 3325 participants, and incident HF hospitalization among 3633 participants with complete data. Results: After adjustment for confounding factors, current smoking was associated with higher mean LV mass index and lower mean LV circumferential strain (P<0.05, for both) in comparison with never smoking. Smoking status, intensity, and burden were associated with higher mean brain natriuretic peptide levels (all P<0.05). Over 8.0 years (7.7-8.0) median follow-up, there were 147 incident HF hospitalizations. After adjustment for traditional risk factors and incident coronary heart disease, current smoking (hazard ratio, 2.82; 95% confidence interval, 1.71-4.64), smoking intensity among current smokers (≥20 cigarettes/d: hazard ratio, 3.48; 95% confidence interval, 1.65-7.32), and smoking burden among ever smokers (≥15 pack-years: hazard ratio, 2.06; 95% confidence interval, 1.29-3.3) were significantly associated with incident HF hospitalization in comparison with never smoking. Conclusions: In blacks, cigarette smoking is an important risk factor for LV hypertrophy, systolic dysfunction, and incident HF hospitalization even after adjusting for effects on coronary heart disease.

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