Chronotype and diurnal patterns of positive affect and affective neural circuitry in primary insomnia

Brant P. Hasler, Anne Germain, Eric A. Nofzinger, David J. Kupfer, Robert T. Krafty, Scott D. Rothenberger, Jeffrey A. James, Wenzhu Bi Mowrey, Daniel J. Buysse

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

While insomnia is a well-established risk factor for the initial onset, recurrence or relapse of affective disorders, the specific characteristics of insomnia that confer risk remain unclear. Patients with insomnia with an evening chronotype may be one particularly high-risk group, perhaps due to alterations in positive affect and its related affective circuitry. We explored this possibility by comparing diurnal patterns of positive affect and the activity of positive affect-related brain regions in morning- and evening-types with insomnia. We assessed diurnal variation in brain activity via the relative regional cerebral metabolic rate of glucose uptake by using [18F]fluorodeoxyglucose-positron emission tomography during morning and evening wakefulness. We focused on regions in the medial prefrontal cortex and striatum, which have been consistently linked with positive affect and reward processing. As predicted, chronotypes differed in their daily patterns in both self-reported positive affect and associated brain regions. Evening-types displayed diurnal patterns of positive affect characterized by phase delay and smaller amplitude compared with those of morning-types with insomnia. In parallel, evening-types showed a reduced degree of diurnal variation in the metabolism of both the medial prefrontal cortex and the striatum, as well as lower overall metabolism in these regions across both morning and evening wakefulness. Taken together, these preliminary findings suggest that alterations in the diurnal activity of positive affect-related neural structures may underlie differences in the phase and amplitude of self-reported positive affect between morning and evening chronotypes, and may constitute one mechanism for increased risk of mood disorders among evening-type insomniacs.

Original languageEnglish (US)
Pages (from-to)515-526
Number of pages12
JournalJournal of Sleep Research
Volume21
Issue number5
DOIs
StatePublished - Oct 2012
Externally publishedYes

Fingerprint

Sleep Initiation and Maintenance Disorders
Wakefulness
Prefrontal Cortex
Mood Disorders
Brain
Recurrence
Fluorodeoxyglucose F18
Reward
Positron-Emission Tomography
Glucose

Keywords

  • Brain metabolism
  • Chronotype
  • Diurnal variation
  • Insomnia
  • Positive affect
  • Positron emission tomography

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Medicine(all)

Cite this

Hasler, B. P., Germain, A., Nofzinger, E. A., Kupfer, D. J., Krafty, R. T., Rothenberger, S. D., ... Buysse, D. J. (2012). Chronotype and diurnal patterns of positive affect and affective neural circuitry in primary insomnia. Journal of Sleep Research, 21(5), 515-526. https://doi.org/10.1111/j.1365-2869.2012.01002.x

Chronotype and diurnal patterns of positive affect and affective neural circuitry in primary insomnia. / Hasler, Brant P.; Germain, Anne; Nofzinger, Eric A.; Kupfer, David J.; Krafty, Robert T.; Rothenberger, Scott D.; James, Jeffrey A.; Mowrey, Wenzhu Bi; Buysse, Daniel J.

In: Journal of Sleep Research, Vol. 21, No. 5, 10.2012, p. 515-526.

Research output: Contribution to journalArticle

Hasler, BP, Germain, A, Nofzinger, EA, Kupfer, DJ, Krafty, RT, Rothenberger, SD, James, JA, Mowrey, WB & Buysse, DJ 2012, 'Chronotype and diurnal patterns of positive affect and affective neural circuitry in primary insomnia', Journal of Sleep Research, vol. 21, no. 5, pp. 515-526. https://doi.org/10.1111/j.1365-2869.2012.01002.x
Hasler, Brant P. ; Germain, Anne ; Nofzinger, Eric A. ; Kupfer, David J. ; Krafty, Robert T. ; Rothenberger, Scott D. ; James, Jeffrey A. ; Mowrey, Wenzhu Bi ; Buysse, Daniel J. / Chronotype and diurnal patterns of positive affect and affective neural circuitry in primary insomnia. In: Journal of Sleep Research. 2012 ; Vol. 21, No. 5. pp. 515-526.
@article{b2bbcf0baa7042e9988d5b2ff2c18f27,
title = "Chronotype and diurnal patterns of positive affect and affective neural circuitry in primary insomnia",
abstract = "While insomnia is a well-established risk factor for the initial onset, recurrence or relapse of affective disorders, the specific characteristics of insomnia that confer risk remain unclear. Patients with insomnia with an evening chronotype may be one particularly high-risk group, perhaps due to alterations in positive affect and its related affective circuitry. We explored this possibility by comparing diurnal patterns of positive affect and the activity of positive affect-related brain regions in morning- and evening-types with insomnia. We assessed diurnal variation in brain activity via the relative regional cerebral metabolic rate of glucose uptake by using [18F]fluorodeoxyglucose-positron emission tomography during morning and evening wakefulness. We focused on regions in the medial prefrontal cortex and striatum, which have been consistently linked with positive affect and reward processing. As predicted, chronotypes differed in their daily patterns in both self-reported positive affect and associated brain regions. Evening-types displayed diurnal patterns of positive affect characterized by phase delay and smaller amplitude compared with those of morning-types with insomnia. In parallel, evening-types showed a reduced degree of diurnal variation in the metabolism of both the medial prefrontal cortex and the striatum, as well as lower overall metabolism in these regions across both morning and evening wakefulness. Taken together, these preliminary findings suggest that alterations in the diurnal activity of positive affect-related neural structures may underlie differences in the phase and amplitude of self-reported positive affect between morning and evening chronotypes, and may constitute one mechanism for increased risk of mood disorders among evening-type insomniacs.",
keywords = "Brain metabolism, Chronotype, Diurnal variation, Insomnia, Positive affect, Positron emission tomography",
author = "Hasler, {Brant P.} and Anne Germain and Nofzinger, {Eric A.} and Kupfer, {David J.} and Krafty, {Robert T.} and Rothenberger, {Scott D.} and James, {Jeffrey A.} and Mowrey, {Wenzhu Bi} and Buysse, {Daniel J.}",
year = "2012",
month = "10",
doi = "10.1111/j.1365-2869.2012.01002.x",
language = "English (US)",
volume = "21",
pages = "515--526",
journal = "Journal of Sleep Research",
issn = "0962-1105",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Chronotype and diurnal patterns of positive affect and affective neural circuitry in primary insomnia

AU - Hasler, Brant P.

AU - Germain, Anne

AU - Nofzinger, Eric A.

AU - Kupfer, David J.

AU - Krafty, Robert T.

AU - Rothenberger, Scott D.

AU - James, Jeffrey A.

AU - Mowrey, Wenzhu Bi

AU - Buysse, Daniel J.

PY - 2012/10

Y1 - 2012/10

N2 - While insomnia is a well-established risk factor for the initial onset, recurrence or relapse of affective disorders, the specific characteristics of insomnia that confer risk remain unclear. Patients with insomnia with an evening chronotype may be one particularly high-risk group, perhaps due to alterations in positive affect and its related affective circuitry. We explored this possibility by comparing diurnal patterns of positive affect and the activity of positive affect-related brain regions in morning- and evening-types with insomnia. We assessed diurnal variation in brain activity via the relative regional cerebral metabolic rate of glucose uptake by using [18F]fluorodeoxyglucose-positron emission tomography during morning and evening wakefulness. We focused on regions in the medial prefrontal cortex and striatum, which have been consistently linked with positive affect and reward processing. As predicted, chronotypes differed in their daily patterns in both self-reported positive affect and associated brain regions. Evening-types displayed diurnal patterns of positive affect characterized by phase delay and smaller amplitude compared with those of morning-types with insomnia. In parallel, evening-types showed a reduced degree of diurnal variation in the metabolism of both the medial prefrontal cortex and the striatum, as well as lower overall metabolism in these regions across both morning and evening wakefulness. Taken together, these preliminary findings suggest that alterations in the diurnal activity of positive affect-related neural structures may underlie differences in the phase and amplitude of self-reported positive affect between morning and evening chronotypes, and may constitute one mechanism for increased risk of mood disorders among evening-type insomniacs.

AB - While insomnia is a well-established risk factor for the initial onset, recurrence or relapse of affective disorders, the specific characteristics of insomnia that confer risk remain unclear. Patients with insomnia with an evening chronotype may be one particularly high-risk group, perhaps due to alterations in positive affect and its related affective circuitry. We explored this possibility by comparing diurnal patterns of positive affect and the activity of positive affect-related brain regions in morning- and evening-types with insomnia. We assessed diurnal variation in brain activity via the relative regional cerebral metabolic rate of glucose uptake by using [18F]fluorodeoxyglucose-positron emission tomography during morning and evening wakefulness. We focused on regions in the medial prefrontal cortex and striatum, which have been consistently linked with positive affect and reward processing. As predicted, chronotypes differed in their daily patterns in both self-reported positive affect and associated brain regions. Evening-types displayed diurnal patterns of positive affect characterized by phase delay and smaller amplitude compared with those of morning-types with insomnia. In parallel, evening-types showed a reduced degree of diurnal variation in the metabolism of both the medial prefrontal cortex and the striatum, as well as lower overall metabolism in these regions across both morning and evening wakefulness. Taken together, these preliminary findings suggest that alterations in the diurnal activity of positive affect-related neural structures may underlie differences in the phase and amplitude of self-reported positive affect between morning and evening chronotypes, and may constitute one mechanism for increased risk of mood disorders among evening-type insomniacs.

KW - Brain metabolism

KW - Chronotype

KW - Diurnal variation

KW - Insomnia

KW - Positive affect

KW - Positron emission tomography

UR - http://www.scopus.com/inward/record.url?scp=84866771302&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84866771302&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2869.2012.01002.x

DO - 10.1111/j.1365-2869.2012.01002.x

M3 - Article

C2 - 22369504

AN - SCOPUS:84866771302

VL - 21

SP - 515

EP - 526

JO - Journal of Sleep Research

JF - Journal of Sleep Research

SN - 0962-1105

IS - 5

ER -