Chronic mucocutaneous candidiasis: T cell deficiency associated with B cell dysfunction in man

Linda T. Cahill; Eugene Ainbender; Philip R. Glade

doi:10.1016/0008-8749(74)90207-X

Chronic mucocutaneous candidiasis: T cell deficiency associated with B cell dysfunction in man

Linda T. Cahill, Eugene Ainbender, Philip R. Glade

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Routine immunologic screening of four patients with chronic mucocutaneous candidiasis (CMC) revealed that they manifested positive Schick tests in vivo despite adequate diphtheria toxoid immunization and the presence of circulating hemagglutinating antibody to diphtheria. Plasma from these individuals was found to neutralize Schick toxin in rabbits. Unlike normal individuals who preferentially make IgG neutralizing antibody to diphtheria toxin when immunized, these patients with CMC have neutralizing activity in plasma fractions containing IgM. IgM is predominantly an intravascular protein which would account for the failure of our patients to neutralize Schick toxin in vivo. These findings suggest that T cell deficiency as it occurs in CMC may lead to B cell dysfunction in man.

Original language	English (US)
Pages (from-to)	215-225
Number of pages	11
Journal	Cellular Immunology
Volume	14
Issue number	2
DOIs	https://doi.org/10.1016/0008-8749(74)90207-X
State	Published - Nov 1974
Externally published	Yes

ASJC Scopus subject areas

Immunology

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@article{a853a6f91bf1403dabe5d014292b0fda,

title = "Chronic mucocutaneous candidiasis: T cell deficiency associated with B cell dysfunction in man",

abstract = "Routine immunologic screening of four patients with chronic mucocutaneous candidiasis (CMC) revealed that they manifested positive Schick tests in vivo despite adequate diphtheria toxoid immunization and the presence of circulating hemagglutinating antibody to diphtheria. Plasma from these individuals was found to neutralize Schick toxin in rabbits. Unlike normal individuals who preferentially make IgG neutralizing antibody to diphtheria toxin when immunized, these patients with CMC have neutralizing activity in plasma fractions containing IgM. IgM is predominantly an intravascular protein which would account for the failure of our patients to neutralize Schick toxin in vivo. These findings suggest that T cell deficiency as it occurs in CMC may lead to B cell dysfunction in man.",

author = "Cahill, {Linda T.} and Eugene Ainbender and Glade, {Philip R.}",

note = "Funding Information: 1 This work was supported by United States Public Health Service Research 10442 and Training Grant No. AI-100445 from the National Institute of Allergy IXseases of the National Institutes of Health. 2 Recipient of United States Public Health Service Research Career Development AI-46371 from the National Institute of Allergy and Infectious Diseases. 3 The Clinical Research Center is supported by Grant No. RR-00071 from The Research Resources, General Clinical Research Center Branch of the National Health.",

year = "1974",

month = nov,

doi = "10.1016/0008-8749(74)90207-X",

language = "English (US)",

volume = "14",

pages = "215--225",

journal = "Cellular Immunology",

issn = "0008-8749",

publisher = "Academic Press Inc.",

number = "2",

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TY - JOUR

T1 - Chronic mucocutaneous candidiasis

T2 - T cell deficiency associated with B cell dysfunction in man

AU - Cahill, Linda T.

AU - Ainbender, Eugene

AU - Glade, Philip R.

N1 - Funding Information: 1 This work was supported by United States Public Health Service Research 10442 and Training Grant No. AI-100445 from the National Institute of Allergy IXseases of the National Institutes of Health. 2 Recipient of United States Public Health Service Research Career Development AI-46371 from the National Institute of Allergy and Infectious Diseases. 3 The Clinical Research Center is supported by Grant No. RR-00071 from The Research Resources, General Clinical Research Center Branch of the National Health.

PY - 1974/11

Y1 - 1974/11

N2 - Routine immunologic screening of four patients with chronic mucocutaneous candidiasis (CMC) revealed that they manifested positive Schick tests in vivo despite adequate diphtheria toxoid immunization and the presence of circulating hemagglutinating antibody to diphtheria. Plasma from these individuals was found to neutralize Schick toxin in rabbits. Unlike normal individuals who preferentially make IgG neutralizing antibody to diphtheria toxin when immunized, these patients with CMC have neutralizing activity in plasma fractions containing IgM. IgM is predominantly an intravascular protein which would account for the failure of our patients to neutralize Schick toxin in vivo. These findings suggest that T cell deficiency as it occurs in CMC may lead to B cell dysfunction in man.

AB - Routine immunologic screening of four patients with chronic mucocutaneous candidiasis (CMC) revealed that they manifested positive Schick tests in vivo despite adequate diphtheria toxoid immunization and the presence of circulating hemagglutinating antibody to diphtheria. Plasma from these individuals was found to neutralize Schick toxin in rabbits. Unlike normal individuals who preferentially make IgG neutralizing antibody to diphtheria toxin when immunized, these patients with CMC have neutralizing activity in plasma fractions containing IgM. IgM is predominantly an intravascular protein which would account for the failure of our patients to neutralize Schick toxin in vivo. These findings suggest that T cell deficiency as it occurs in CMC may lead to B cell dysfunction in man.

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JO - Cellular Immunology

JF - Cellular Immunology

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ER -

Chronic mucocutaneous candidiasis: T cell deficiency associated with B cell dysfunction in man

Abstract

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