Chronic mucocutaneous candidiasis: T cell deficiency associated with B cell dysfunction in man

Linda Theill Cahill, Eugene Ainbender, Philip R. Glade

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Routine immunologic screening of four patients with chronic mucocutaneous candidiasis (CMC) revealed that they manifested positive Schick tests in vivo despite adequate diphtheria toxoid immunization and the presence of circulating hemagglutinating antibody to diphtheria. Plasma from these individuals was found to neutralize Schick toxin in rabbits. Unlike normal individuals who preferentially make IgG neutralizing antibody to diphtheria toxin when immunized, these patients with CMC have neutralizing activity in plasma fractions containing IgM. IgM is predominantly an intravascular protein which would account for the failure of our patients to neutralize Schick toxin in vivo. These findings suggest that T cell deficiency as it occurs in CMC may lead to B cell dysfunction in man.

Original languageEnglish (US)
Pages (from-to)215-225
Number of pages11
JournalCellular Immunology
Volume14
Issue number2
DOIs
StatePublished - 1974
Externally publishedYes

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Chronic Mucocutaneous Candidiasis
B-Lymphocytes
T-Lymphocytes
Immunoglobulin M
Diphtheria Toxoid
Diphtheria Toxin
Diphtheria
Neutralizing Antibodies
Immunization
Immunoglobulin G
Rabbits
Antibodies
Proteins

ASJC Scopus subject areas

  • Immunology

Cite this

Chronic mucocutaneous candidiasis : T cell deficiency associated with B cell dysfunction in man. / Cahill, Linda Theill; Ainbender, Eugene; Glade, Philip R.

In: Cellular Immunology, Vol. 14, No. 2, 1974, p. 215-225.

Research output: Contribution to journalArticle

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