Chronic migraine is an earlier stage of transformed migraine in adults

M. E. Bigal, A. M. Rapoport, F. D. Sheftell, S. J. Tepper, Richard B. Lipton

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Background: Chronic migraine (CM) is characterized by 15 or more migraine days per month. Most adults with chronic daily headache (CDH) that evolved from migraine have <15 days of migraine/month. They are often classified as transformed migraine (TM), a disorder not addressed in the International Headache Society classification. Objective: To test the hypothesis that early in the course of migraine chronification, the frequency of migraine attacks is high and that as illness progresses the frequency of nonmigraine headaches increases. Methods: Information was collected on 402 adults with TM and was divided into two groups. Group 1 TM had a 15 days of migraine/month, whereas Group 2 TM had <15 days of migraine/month. Risk factors were modeled for number of migraine days per month using logistic regression. Results: Of 402 subjects with TM, 121 (30.1%) were in Group 1. The proportion of Group 1 subjects decreased with age, from 71% below age 30 to 22% age 60 or above. The correspondent proportion of Group 2 increased from 29 to 78%. More than 15 days of migraine per month was independently predicted by younger ages (<40 years; p = 0.002), shorter interval from episodic to CDH (<5 years; p = 0.003), and shorter time since the development of CDH (<6 years; p < 0.0001). Conclusion: Chronic migraine is an earlier stage of transformed migraine.

Original languageEnglish (US)
Pages (from-to)1556-1561
Number of pages6
JournalNeurology
Volume65
Issue number10
DOIs
StatePublished - Nov 2005

Fingerprint

Migraine Disorders
Headache Disorders
Headache

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Chronic migraine is an earlier stage of transformed migraine in adults. / Bigal, M. E.; Rapoport, A. M.; Sheftell, F. D.; Tepper, S. J.; Lipton, Richard B.

In: Neurology, Vol. 65, No. 10, 11.2005, p. 1556-1561.

Research output: Contribution to journalArticle

Bigal, M. E. ; Rapoport, A. M. ; Sheftell, F. D. ; Tepper, S. J. ; Lipton, Richard B. / Chronic migraine is an earlier stage of transformed migraine in adults. In: Neurology. 2005 ; Vol. 65, No. 10. pp. 1556-1561.
@article{5fa955cc72c74a449485a9897c28349c,
title = "Chronic migraine is an earlier stage of transformed migraine in adults",
abstract = "Background: Chronic migraine (CM) is characterized by 15 or more migraine days per month. Most adults with chronic daily headache (CDH) that evolved from migraine have <15 days of migraine/month. They are often classified as transformed migraine (TM), a disorder not addressed in the International Headache Society classification. Objective: To test the hypothesis that early in the course of migraine chronification, the frequency of migraine attacks is high and that as illness progresses the frequency of nonmigraine headaches increases. Methods: Information was collected on 402 adults with TM and was divided into two groups. Group 1 TM had a 15 days of migraine/month, whereas Group 2 TM had <15 days of migraine/month. Risk factors were modeled for number of migraine days per month using logistic regression. Results: Of 402 subjects with TM, 121 (30.1{\%}) were in Group 1. The proportion of Group 1 subjects decreased with age, from 71{\%} below age 30 to 22{\%} age 60 or above. The correspondent proportion of Group 2 increased from 29 to 78{\%}. More than 15 days of migraine per month was independently predicted by younger ages (<40 years; p = 0.002), shorter interval from episodic to CDH (<5 years; p = 0.003), and shorter time since the development of CDH (<6 years; p < 0.0001). Conclusion: Chronic migraine is an earlier stage of transformed migraine.",
author = "Bigal, {M. E.} and Rapoport, {A. M.} and Sheftell, {F. D.} and Tepper, {S. J.} and Lipton, {Richard B.}",
year = "2005",
month = "11",
doi = "10.1212/01.wnl.0000184477.11569.17",
language = "English (US)",
volume = "65",
pages = "1556--1561",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "10",

}

TY - JOUR

T1 - Chronic migraine is an earlier stage of transformed migraine in adults

AU - Bigal, M. E.

AU - Rapoport, A. M.

AU - Sheftell, F. D.

AU - Tepper, S. J.

AU - Lipton, Richard B.

PY - 2005/11

Y1 - 2005/11

N2 - Background: Chronic migraine (CM) is characterized by 15 or more migraine days per month. Most adults with chronic daily headache (CDH) that evolved from migraine have <15 days of migraine/month. They are often classified as transformed migraine (TM), a disorder not addressed in the International Headache Society classification. Objective: To test the hypothesis that early in the course of migraine chronification, the frequency of migraine attacks is high and that as illness progresses the frequency of nonmigraine headaches increases. Methods: Information was collected on 402 adults with TM and was divided into two groups. Group 1 TM had a 15 days of migraine/month, whereas Group 2 TM had <15 days of migraine/month. Risk factors were modeled for number of migraine days per month using logistic regression. Results: Of 402 subjects with TM, 121 (30.1%) were in Group 1. The proportion of Group 1 subjects decreased with age, from 71% below age 30 to 22% age 60 or above. The correspondent proportion of Group 2 increased from 29 to 78%. More than 15 days of migraine per month was independently predicted by younger ages (<40 years; p = 0.002), shorter interval from episodic to CDH (<5 years; p = 0.003), and shorter time since the development of CDH (<6 years; p < 0.0001). Conclusion: Chronic migraine is an earlier stage of transformed migraine.

AB - Background: Chronic migraine (CM) is characterized by 15 or more migraine days per month. Most adults with chronic daily headache (CDH) that evolved from migraine have <15 days of migraine/month. They are often classified as transformed migraine (TM), a disorder not addressed in the International Headache Society classification. Objective: To test the hypothesis that early in the course of migraine chronification, the frequency of migraine attacks is high and that as illness progresses the frequency of nonmigraine headaches increases. Methods: Information was collected on 402 adults with TM and was divided into two groups. Group 1 TM had a 15 days of migraine/month, whereas Group 2 TM had <15 days of migraine/month. Risk factors were modeled for number of migraine days per month using logistic regression. Results: Of 402 subjects with TM, 121 (30.1%) were in Group 1. The proportion of Group 1 subjects decreased with age, from 71% below age 30 to 22% age 60 or above. The correspondent proportion of Group 2 increased from 29 to 78%. More than 15 days of migraine per month was independently predicted by younger ages (<40 years; p = 0.002), shorter interval from episodic to CDH (<5 years; p = 0.003), and shorter time since the development of CDH (<6 years; p < 0.0001). Conclusion: Chronic migraine is an earlier stage of transformed migraine.

UR - http://www.scopus.com/inward/record.url?scp=28044444759&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=28044444759&partnerID=8YFLogxK

U2 - 10.1212/01.wnl.0000184477.11569.17

DO - 10.1212/01.wnl.0000184477.11569.17

M3 - Article

C2 - 16301481

AN - SCOPUS:28044444759

VL - 65

SP - 1556

EP - 1561

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 10

ER -