Chronic lyme arthritis. Clinical and immunogenetic differentiation from rheumatoid arthritis

A. C. Steere, A. Gibofsky, M. E. Patarroyo, R. J. Winchester, J. A. Hardin, S. E. Malawista

Research output: Contribution to journalArticle

180 Citations (Scopus)

Abstract

Ten patients with Lyme arthritis have developed chronic involvement of one or both knees. Lyme arthritis was diagnosed by onset with erythema chronicum migrans (six patients); residence in Lyme, Connecticut (eight); seasonal onset in summer and early fall (nine); early periods of short recurrent attacks (nine); absence of rheumatoid factor (nine); and absence of symmetrical polyarthritis, morning stiffness, subcutaneous nodules, or antinuclear antibodies (in all). Five patients had synovectomies; pannus formation and underlying cartilage erosion were present in all. Seven of the 10 patients had the same B-cell alloantigen, DRw2 (frequency in normal control subjects, 22% [P<0.005]), but did not have an increased frequency of the alloantigens associated with rheumatoid arthritis. Chronic Lyme arthritis, the result of an apparent tick-transmitted infection, resembles rheumatoid arthritis pathologically but generally differs from it in both prearticular and immunogenetic characteristics.

Original languageEnglish (US)
Pages (from-to)896-901
Number of pages6
JournalAnnals of Internal Medicine
Volume90
Issue number6
StatePublished - 1979
Externally publishedYes

Fingerprint

Immunogenetics
Lyme Disease
Rheumatoid Arthritis
Isoantigens
Erythema Chronicum Migrans
Rheumatoid Factor
Antinuclear Antibodies
Ticks
Arthritis
Cartilage
Knee
B-Lymphocytes
Infection

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Steere, A. C., Gibofsky, A., Patarroyo, M. E., Winchester, R. J., Hardin, J. A., & Malawista, S. E. (1979). Chronic lyme arthritis. Clinical and immunogenetic differentiation from rheumatoid arthritis. Annals of Internal Medicine, 90(6), 896-901.

Chronic lyme arthritis. Clinical and immunogenetic differentiation from rheumatoid arthritis. / Steere, A. C.; Gibofsky, A.; Patarroyo, M. E.; Winchester, R. J.; Hardin, J. A.; Malawista, S. E.

In: Annals of Internal Medicine, Vol. 90, No. 6, 1979, p. 896-901.

Research output: Contribution to journalArticle

Steere, AC, Gibofsky, A, Patarroyo, ME, Winchester, RJ, Hardin, JA & Malawista, SE 1979, 'Chronic lyme arthritis. Clinical and immunogenetic differentiation from rheumatoid arthritis', Annals of Internal Medicine, vol. 90, no. 6, pp. 896-901.
Steere AC, Gibofsky A, Patarroyo ME, Winchester RJ, Hardin JA, Malawista SE. Chronic lyme arthritis. Clinical and immunogenetic differentiation from rheumatoid arthritis. Annals of Internal Medicine. 1979;90(6):896-901.
Steere, A. C. ; Gibofsky, A. ; Patarroyo, M. E. ; Winchester, R. J. ; Hardin, J. A. ; Malawista, S. E. / Chronic lyme arthritis. Clinical and immunogenetic differentiation from rheumatoid arthritis. In: Annals of Internal Medicine. 1979 ; Vol. 90, No. 6. pp. 896-901.
@article{f9fd4e3903b44a85a01a438e2f07b6af,
title = "Chronic lyme arthritis. Clinical and immunogenetic differentiation from rheumatoid arthritis",
abstract = "Ten patients with Lyme arthritis have developed chronic involvement of one or both knees. Lyme arthritis was diagnosed by onset with erythema chronicum migrans (six patients); residence in Lyme, Connecticut (eight); seasonal onset in summer and early fall (nine); early periods of short recurrent attacks (nine); absence of rheumatoid factor (nine); and absence of symmetrical polyarthritis, morning stiffness, subcutaneous nodules, or antinuclear antibodies (in all). Five patients had synovectomies; pannus formation and underlying cartilage erosion were present in all. Seven of the 10 patients had the same B-cell alloantigen, DRw2 (frequency in normal control subjects, 22{\%} [P<0.005]), but did not have an increased frequency of the alloantigens associated with rheumatoid arthritis. Chronic Lyme arthritis, the result of an apparent tick-transmitted infection, resembles rheumatoid arthritis pathologically but generally differs from it in both prearticular and immunogenetic characteristics.",
author = "Steere, {A. C.} and A. Gibofsky and Patarroyo, {M. E.} and Winchester, {R. J.} and Hardin, {J. A.} and Malawista, {S. E.}",
year = "1979",
language = "English (US)",
volume = "90",
pages = "896--901",
journal = "Annals of Internal Medicine",
issn = "0003-4819",
publisher = "American College of Physicians",
number = "6",

}

TY - JOUR

T1 - Chronic lyme arthritis. Clinical and immunogenetic differentiation from rheumatoid arthritis

AU - Steere, A. C.

AU - Gibofsky, A.

AU - Patarroyo, M. E.

AU - Winchester, R. J.

AU - Hardin, J. A.

AU - Malawista, S. E.

PY - 1979

Y1 - 1979

N2 - Ten patients with Lyme arthritis have developed chronic involvement of one or both knees. Lyme arthritis was diagnosed by onset with erythema chronicum migrans (six patients); residence in Lyme, Connecticut (eight); seasonal onset in summer and early fall (nine); early periods of short recurrent attacks (nine); absence of rheumatoid factor (nine); and absence of symmetrical polyarthritis, morning stiffness, subcutaneous nodules, or antinuclear antibodies (in all). Five patients had synovectomies; pannus formation and underlying cartilage erosion were present in all. Seven of the 10 patients had the same B-cell alloantigen, DRw2 (frequency in normal control subjects, 22% [P<0.005]), but did not have an increased frequency of the alloantigens associated with rheumatoid arthritis. Chronic Lyme arthritis, the result of an apparent tick-transmitted infection, resembles rheumatoid arthritis pathologically but generally differs from it in both prearticular and immunogenetic characteristics.

AB - Ten patients with Lyme arthritis have developed chronic involvement of one or both knees. Lyme arthritis was diagnosed by onset with erythema chronicum migrans (six patients); residence in Lyme, Connecticut (eight); seasonal onset in summer and early fall (nine); early periods of short recurrent attacks (nine); absence of rheumatoid factor (nine); and absence of symmetrical polyarthritis, morning stiffness, subcutaneous nodules, or antinuclear antibodies (in all). Five patients had synovectomies; pannus formation and underlying cartilage erosion were present in all. Seven of the 10 patients had the same B-cell alloantigen, DRw2 (frequency in normal control subjects, 22% [P<0.005]), but did not have an increased frequency of the alloantigens associated with rheumatoid arthritis. Chronic Lyme arthritis, the result of an apparent tick-transmitted infection, resembles rheumatoid arthritis pathologically but generally differs from it in both prearticular and immunogenetic characteristics.

UR - http://www.scopus.com/inward/record.url?scp=0018293716&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018293716&partnerID=8YFLogxK

M3 - Article

VL - 90

SP - 896

EP - 901

JO - Annals of Internal Medicine

JF - Annals of Internal Medicine

SN - 0003-4819

IS - 6

ER -