Chronic kidney disease in non-diabetic older adults: Associated roles of the metabolic syndrome, inflammation, and insulin resistance

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Abstract

Background: The aims of the study were to examine the association between CKD and the metabolic syndrome (MetS) and its components in older adults. We also explored two possible pathways linking the metabolic syndrome with CKD: inflammation as measured by high sensitivity C-Reactive Protein (hsCRP) and insulin resistance as measured by HOMA-IR. Methods: Community-dwelling non-diabetic 70+ adults from the Einstein Aging Study participated in the study. We defined CKD as eGFR below 60mL/min/1.73m2. MetS was defined according to recent guidelines from the National Cholesterol Education Program. Binary logistic regressions were used to assess the association between the metabolic syndrome, its components and CKD with adjustments for demographics, HOMA-IR and hsCRP. Results: Of 616 participants (mean age = 79.3 years, 65.5%female), 25% had MetS and 26.5%had CKD. Participants with CKD had a significantly higher prevalence of the MetS than individuals without CKD (34.4% vs. 24.3%). Binary logistic regression models showed that CKD was associated with MetS (OR = 1.72, 95%CI = 1.13-2.61). The association was unaltered by adjustment for hsCRP but altered by adjustment for HOMA-IR. As the number of MetS components increased the relative odds of CKD also increased. None of the individual components was independently associated with CKD. Conclusion: MetS is associated with CKD in non-diabetic older adults. Results showed that as the number of MetS components increased so did the odds for CKD. HOMA-IR seems to be in the casual pathway linking MetS to CKD.

Original languageEnglish (US)
Article numbere0139369
JournalPLoS One
Volume10
Issue number10
DOIs
StatePublished - Oct 2 2015

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metabolic syndrome
kidney diseases
Chronic Renal Insufficiency
insulin resistance
C-Reactive Protein
Insulin Resistance
inflammation
Insulin
Inflammation
Logistics
C-reactive protein
Aging of materials
Education
Cholesterol
Logistic Models
Metabolic Networks and Pathways
Independent Living
demographic statistics
Odds Ratio
Demography

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

@article{95a45bc748a6428da44607b32d541d53,
title = "Chronic kidney disease in non-diabetic older adults: Associated roles of the metabolic syndrome, inflammation, and insulin resistance",
abstract = "Background: The aims of the study were to examine the association between CKD and the metabolic syndrome (MetS) and its components in older adults. We also explored two possible pathways linking the metabolic syndrome with CKD: inflammation as measured by high sensitivity C-Reactive Protein (hsCRP) and insulin resistance as measured by HOMA-IR. Methods: Community-dwelling non-diabetic 70+ adults from the Einstein Aging Study participated in the study. We defined CKD as eGFR below 60mL/min/1.73m2. MetS was defined according to recent guidelines from the National Cholesterol Education Program. Binary logistic regressions were used to assess the association between the metabolic syndrome, its components and CKD with adjustments for demographics, HOMA-IR and hsCRP. Results: Of 616 participants (mean age = 79.3 years, 65.5{\%}female), 25{\%} had MetS and 26.5{\%}had CKD. Participants with CKD had a significantly higher prevalence of the MetS than individuals without CKD (34.4{\%} vs. 24.3{\%}). Binary logistic regression models showed that CKD was associated with MetS (OR = 1.72, 95{\%}CI = 1.13-2.61). The association was unaltered by adjustment for hsCRP but altered by adjustment for HOMA-IR. As the number of MetS components increased the relative odds of CKD also increased. None of the individual components was independently associated with CKD. Conclusion: MetS is associated with CKD in non-diabetic older adults. Results showed that as the number of MetS components increased so did the odds for CKD. HOMA-IR seems to be in the casual pathway linking MetS to CKD.",
author = "Zammit, {Andrea R.} and Katz, {Mindy Joy} and Derby, {Carol A.} and Markus Bitzer and Lipton, {Richard B.}",
year = "2015",
month = "10",
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doi = "10.1371/journal.pone.0139369",
language = "English (US)",
volume = "10",
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T1 - Chronic kidney disease in non-diabetic older adults

T2 - Associated roles of the metabolic syndrome, inflammation, and insulin resistance

AU - Zammit, Andrea R.

AU - Katz, Mindy Joy

AU - Derby, Carol A.

AU - Bitzer, Markus

AU - Lipton, Richard B.

PY - 2015/10/2

Y1 - 2015/10/2

N2 - Background: The aims of the study were to examine the association between CKD and the metabolic syndrome (MetS) and its components in older adults. We also explored two possible pathways linking the metabolic syndrome with CKD: inflammation as measured by high sensitivity C-Reactive Protein (hsCRP) and insulin resistance as measured by HOMA-IR. Methods: Community-dwelling non-diabetic 70+ adults from the Einstein Aging Study participated in the study. We defined CKD as eGFR below 60mL/min/1.73m2. MetS was defined according to recent guidelines from the National Cholesterol Education Program. Binary logistic regressions were used to assess the association between the metabolic syndrome, its components and CKD with adjustments for demographics, HOMA-IR and hsCRP. Results: Of 616 participants (mean age = 79.3 years, 65.5%female), 25% had MetS and 26.5%had CKD. Participants with CKD had a significantly higher prevalence of the MetS than individuals without CKD (34.4% vs. 24.3%). Binary logistic regression models showed that CKD was associated with MetS (OR = 1.72, 95%CI = 1.13-2.61). The association was unaltered by adjustment for hsCRP but altered by adjustment for HOMA-IR. As the number of MetS components increased the relative odds of CKD also increased. None of the individual components was independently associated with CKD. Conclusion: MetS is associated with CKD in non-diabetic older adults. Results showed that as the number of MetS components increased so did the odds for CKD. HOMA-IR seems to be in the casual pathway linking MetS to CKD.

AB - Background: The aims of the study were to examine the association between CKD and the metabolic syndrome (MetS) and its components in older adults. We also explored two possible pathways linking the metabolic syndrome with CKD: inflammation as measured by high sensitivity C-Reactive Protein (hsCRP) and insulin resistance as measured by HOMA-IR. Methods: Community-dwelling non-diabetic 70+ adults from the Einstein Aging Study participated in the study. We defined CKD as eGFR below 60mL/min/1.73m2. MetS was defined according to recent guidelines from the National Cholesterol Education Program. Binary logistic regressions were used to assess the association between the metabolic syndrome, its components and CKD with adjustments for demographics, HOMA-IR and hsCRP. Results: Of 616 participants (mean age = 79.3 years, 65.5%female), 25% had MetS and 26.5%had CKD. Participants with CKD had a significantly higher prevalence of the MetS than individuals without CKD (34.4% vs. 24.3%). Binary logistic regression models showed that CKD was associated with MetS (OR = 1.72, 95%CI = 1.13-2.61). The association was unaltered by adjustment for hsCRP but altered by adjustment for HOMA-IR. As the number of MetS components increased the relative odds of CKD also increased. None of the individual components was independently associated with CKD. Conclusion: MetS is associated with CKD in non-diabetic older adults. Results showed that as the number of MetS components increased so did the odds for CKD. HOMA-IR seems to be in the casual pathway linking MetS to CKD.

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