Chronic inflammatory effects of interleukin-1 on the blood-retina barrier

James A. Martiney, Joan W. Berman, Celia F. Brosnan

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

The chronic effects of human recombinant IL-1 (hrIL-1) on the specialized vasculature of the central nervous system (CNS) and on the CNS itself have been examined ove a 35-day period in the rabbit retina. A single intraocular injection of physiological levels of hrIL-1 (300 units) induced a biphasic inflammatory reaction with well-defined acute and chronic phases in the challenged eye. Quantitative histopathological examination of the vascularized portion of the retina in the IL-1-challenged eye documented a persistent mononuclear (MN) cell response that peaked 7-14 days post-challenge. Included in the MN cell count were perivascular plasma cells. Elevated protein levels in the vitreous persisted throughou the time points studied and alterations in vascular permeability of the epiretinal vessels were demonstrated by tracer leakage at 2 weeks post-challenge. The results show that exposure of the CNS-vasulature to IL-1 nduced long-lasting inflammatory changes typical of a chronic inflammatory reaction.

Original languageEnglish (US)
Pages (from-to)167-176
Number of pages10
JournalJournal of Neuroimmunology
Volume41
Issue number2
DOIs
StatePublished - Dec 1992

Keywords

  • Blood-brain barrier
  • Cytokine-induced
  • Mononuclear cell
  • Rabbit
  • Ultrastructure
  • Vascular permeability

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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