Chronic inflammatory effects of interleukin-1 on the blood-retina barrier

James A. Martiney, Joan W. Berman, Celia F. Brosnan

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The chronic effects of human recombinant IL-1 (hrIL-1) on the specialized vasculature of the central nervous system (CNS) and on the CNS itself have been examined ove a 35-day period in the rabbit retina. A single intraocular injection of physiological levels of hrIL-1 (300 units) induced a biphasic inflammatory reaction with well-defined acute and chronic phases in the challenged eye. Quantitative histopathological examination of the vascularized portion of the retina in the IL-1-challenged eye documented a persistent mononuclear (MN) cell response that peaked 7-14 days post-challenge. Included in the MN cell count were perivascular plasma cells. Elevated protein levels in the vitreous persisted throughou the time points studied and alterations in vascular permeability of the epiretinal vessels were demonstrated by tracer leakage at 2 weeks post-challenge. The results show that exposure of the CNS-vasulature to IL-1 nduced long-lasting inflammatory changes typical of a chronic inflammatory reaction.

Original languageEnglish (US)
Pages (from-to)167-176
Number of pages10
JournalJournal of Neuroimmunology
Volume41
Issue number2
DOIs
StatePublished - 1992

Fingerprint

Interleukin-1
Retina
Central Nervous System
Intraocular Injections
Capillary Permeability
Plasma Cells
Cell Count
Rabbits
Proteins

Keywords

  • Blood-brain barrier
  • Cytokine-induced
  • Mononuclear cell
  • Rabbit
  • Ultrastructure
  • Vascular permeability

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Neurology
  • Neurology

Cite this

Chronic inflammatory effects of interleukin-1 on the blood-retina barrier. / Martiney, James A.; Berman, Joan W.; Brosnan, Celia F.

In: Journal of Neuroimmunology, Vol. 41, No. 2, 1992, p. 167-176.

Research output: Contribution to journalArticle

Martiney, James A. ; Berman, Joan W. ; Brosnan, Celia F. / Chronic inflammatory effects of interleukin-1 on the blood-retina barrier. In: Journal of Neuroimmunology. 1992 ; Vol. 41, No. 2. pp. 167-176.
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