Chronic inflammation in the etiology of disease across the life span

David Furman; Judith Campisi; Eric Verdin; Pedro Carrera-Bastos; Sasha Targ; Claudio Franceschi; Luigi Ferrucci; Derek W. Gilroy; Alessio Fasano; Gary W. Miller; Andrew H. Miller; Alberto Mantovani; Cornelia M. Weyand; Nir Barzilai; Jorg J. Goronzy; Thomas A. Rando; Rita B. Effros; Alejandro Lucia; Nicole Kleinstreuer; George M. Slavich

doi:10.1038/s41591-019-0675-0

Chronic inflammation in the etiology of disease across the life span

David Furman, Judith Campisi, Eric Verdin, Pedro Carrera-Bastos, Sasha Targ, Claudio Franceschi, Luigi Ferrucci, Derek W. Gilroy, Alessio Fasano, Gary W. Miller, Andrew H. Miller, Alberto Mantovani, Cornelia M. Weyand, Nir Barzilai, Jorg J. Goronzy, Thomas A. Rando, Rita B. Effros, Alejandro Lucia, Nicole Kleinstreuer, George M. Slavich

Medicine

Research output: Contribution to journal › Article › peer-review

2104 Scopus citations

Abstract

Although intermittent increases in inflammation are critical for survival during physical injury and infection, recent research has revealed that certain social, environmental and lifestyle factors can promote systemic chronic inflammation (SCI) that can, in turn, lead to several diseases that collectively represent the leading causes of disability and mortality worldwide, such as cardiovascular disease, cancer, diabetes mellitus, chronic kidney disease, non-alcoholic fatty liver disease and autoimmune and neurodegenerative disorders. In the present Perspective we describe the multi-level mechanisms underlying SCI and several risk factors that promote this health-damaging phenotype, including infections, physical inactivity, poor diet, environmental and industrial toxicants and psychological stress. Furthermore, we suggest potential strategies for advancing the early diagnosis, prevention and treatment of SCI.

Original language	English (US)
Pages (from-to)	1822-1832
Number of pages	11
Journal	Nature Medicine
Volume	25
Issue number	12
DOIs	https://doi.org/10.1038/s41591-019-0675-0
State	Published - Dec 1 2019

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41591-019-0675-0

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Furman, D., Campisi, J., Verdin, E., Carrera-Bastos, P., Targ, S., Franceschi, C., Ferrucci, L., Gilroy, D. W., Fasano, A., Miller, G. W., Miller, A. H., Mantovani, A., Weyand, C. M., Barzilai, N., Goronzy, J. J., Rando, T. A., Effros, R. B., Lucia, A., Kleinstreuer, N., & Slavich, G. M. (2019). Chronic inflammation in the etiology of disease across the life span. Nature Medicine, 25(12), 1822-1832. https://doi.org/10.1038/s41591-019-0675-0

Furman, D, Campisi, J, Verdin, E, Carrera-Bastos, P, Targ, S, Franceschi, C, Ferrucci, L, Gilroy, DW, Fasano, A, Miller, GW, Miller, AH, Mantovani, A, Weyand, CM, Barzilai, N, Goronzy, JJ, Rando, TA, Effros, RB, Lucia, A, Kleinstreuer, N & Slavich, GM 2019, 'Chronic inflammation in the etiology of disease across the life span', Nature Medicine, vol. 25, no. 12, pp. 1822-1832. https://doi.org/10.1038/s41591-019-0675-0

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Chronic inflammation in the etiology of disease across the life span

Abstract

ASJC Scopus subject areas

UN SDGs

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