Chronic critical illness

Judith E. Nelson, Christopher E. Cox, Aluko A. Hope, Shannon S. Carson

Research output: Contribution to journalArticle

265 Citations (Scopus)

Abstract

Although advances in intensive care have enabled more patients to survive an acute critical illness, they also have created a large and growing population of chronically critically ill patients with prolonged dependence on mechanical ventilation and other intensive care therapies. Chronic critical illness is a devastating condition: mortality exceeds that for most malignancies, and functional dependence persists for most survivors. Costs of treating the chronically critically ill in the United States already exceed $20 billion and are increasing. In this article, we describe the constellation of clinical features that characterize chronic critical illness. We discuss the outcomes of this condition including ventilator liberation, mortality, and physical and cognitive function, noting that comparisons among cohorts are complicated by variation in defining criteria and care settings. We also address burdens for families of the chronically critically ill and the difficulties they face in decision-making about continuation of intensive therapies. Epidemiology and resource utilization issues are reviewed to highlight the impact of chronic critical illness on our health care system. Finally, we summarize the best available evidence for managing chronic critical illness, including ventilator weaning, nutritional support, rehabilitation, and palliative care, and emphasize the importance of efforts to prevent the transition from acute to chronic critical illness. As steps forward for the field,wesuggest a specific definition of chronic critical illness, advocate for the creation of a research network encompassing a broad range of venues for care, and highlight areas for future study of the comparative effectiveness of different treatment venues and approaches.

Original languageEnglish (US)
Pages (from-to)446-454
Number of pages9
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume182
Issue number4
DOIs
StatePublished - Aug 15 2010
Externally publishedYes

Fingerprint

Critical Illness
Chronic Disease
Critical Care
Ventilator Weaning
Nutritional Support
Mortality
Mechanical Ventilators
Palliative Care
Artificial Respiration
Cognition
Survivors
Decision Making
Epidemiology
Rehabilitation
Delivery of Health Care
Costs and Cost Analysis
Therapeutics
Research

Keywords

  • Artificial
  • Chronic disease
  • Critical illness
  • Respirator
  • Respiratory care units

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Chronic critical illness. / Nelson, Judith E.; Cox, Christopher E.; Hope, Aluko A.; Carson, Shannon S.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 182, No. 4, 15.08.2010, p. 446-454.

Research output: Contribution to journalArticle

Nelson, Judith E. ; Cox, Christopher E. ; Hope, Aluko A. ; Carson, Shannon S. / Chronic critical illness. In: American Journal of Respiratory and Critical Care Medicine. 2010 ; Vol. 182, No. 4. pp. 446-454.
@article{c66af53c7a574d3fb5e8150d2da24ad0,
title = "Chronic critical illness",
abstract = "Although advances in intensive care have enabled more patients to survive an acute critical illness, they also have created a large and growing population of chronically critically ill patients with prolonged dependence on mechanical ventilation and other intensive care therapies. Chronic critical illness is a devastating condition: mortality exceeds that for most malignancies, and functional dependence persists for most survivors. Costs of treating the chronically critically ill in the United States already exceed $20 billion and are increasing. In this article, we describe the constellation of clinical features that characterize chronic critical illness. We discuss the outcomes of this condition including ventilator liberation, mortality, and physical and cognitive function, noting that comparisons among cohorts are complicated by variation in defining criteria and care settings. We also address burdens for families of the chronically critically ill and the difficulties they face in decision-making about continuation of intensive therapies. Epidemiology and resource utilization issues are reviewed to highlight the impact of chronic critical illness on our health care system. Finally, we summarize the best available evidence for managing chronic critical illness, including ventilator weaning, nutritional support, rehabilitation, and palliative care, and emphasize the importance of efforts to prevent the transition from acute to chronic critical illness. As steps forward for the field,wesuggest a specific definition of chronic critical illness, advocate for the creation of a research network encompassing a broad range of venues for care, and highlight areas for future study of the comparative effectiveness of different treatment venues and approaches.",
keywords = "Artificial, Chronic disease, Critical illness, Respirator, Respiratory care units",
author = "Nelson, {Judith E.} and Cox, {Christopher E.} and Hope, {Aluko A.} and Carson, {Shannon S.}",
year = "2010",
month = "8",
day = "15",
doi = "10.1164/rccm.201002-0210CI",
language = "English (US)",
volume = "182",
pages = "446--454",
journal = "American Journal of Respiratory and Critical Care Medicine",
issn = "1073-449X",
publisher = "American Thoracic Society",
number = "4",

}

TY - JOUR

T1 - Chronic critical illness

AU - Nelson, Judith E.

AU - Cox, Christopher E.

AU - Hope, Aluko A.

AU - Carson, Shannon S.

PY - 2010/8/15

Y1 - 2010/8/15

N2 - Although advances in intensive care have enabled more patients to survive an acute critical illness, they also have created a large and growing population of chronically critically ill patients with prolonged dependence on mechanical ventilation and other intensive care therapies. Chronic critical illness is a devastating condition: mortality exceeds that for most malignancies, and functional dependence persists for most survivors. Costs of treating the chronically critically ill in the United States already exceed $20 billion and are increasing. In this article, we describe the constellation of clinical features that characterize chronic critical illness. We discuss the outcomes of this condition including ventilator liberation, mortality, and physical and cognitive function, noting that comparisons among cohorts are complicated by variation in defining criteria and care settings. We also address burdens for families of the chronically critically ill and the difficulties they face in decision-making about continuation of intensive therapies. Epidemiology and resource utilization issues are reviewed to highlight the impact of chronic critical illness on our health care system. Finally, we summarize the best available evidence for managing chronic critical illness, including ventilator weaning, nutritional support, rehabilitation, and palliative care, and emphasize the importance of efforts to prevent the transition from acute to chronic critical illness. As steps forward for the field,wesuggest a specific definition of chronic critical illness, advocate for the creation of a research network encompassing a broad range of venues for care, and highlight areas for future study of the comparative effectiveness of different treatment venues and approaches.

AB - Although advances in intensive care have enabled more patients to survive an acute critical illness, they also have created a large and growing population of chronically critically ill patients with prolonged dependence on mechanical ventilation and other intensive care therapies. Chronic critical illness is a devastating condition: mortality exceeds that for most malignancies, and functional dependence persists for most survivors. Costs of treating the chronically critically ill in the United States already exceed $20 billion and are increasing. In this article, we describe the constellation of clinical features that characterize chronic critical illness. We discuss the outcomes of this condition including ventilator liberation, mortality, and physical and cognitive function, noting that comparisons among cohorts are complicated by variation in defining criteria and care settings. We also address burdens for families of the chronically critically ill and the difficulties they face in decision-making about continuation of intensive therapies. Epidemiology and resource utilization issues are reviewed to highlight the impact of chronic critical illness on our health care system. Finally, we summarize the best available evidence for managing chronic critical illness, including ventilator weaning, nutritional support, rehabilitation, and palliative care, and emphasize the importance of efforts to prevent the transition from acute to chronic critical illness. As steps forward for the field,wesuggest a specific definition of chronic critical illness, advocate for the creation of a research network encompassing a broad range of venues for care, and highlight areas for future study of the comparative effectiveness of different treatment venues and approaches.

KW - Artificial

KW - Chronic disease

KW - Critical illness

KW - Respirator

KW - Respiratory care units

UR - http://www.scopus.com/inward/record.url?scp=77957058329&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77957058329&partnerID=8YFLogxK

U2 - 10.1164/rccm.201002-0210CI

DO - 10.1164/rccm.201002-0210CI

M3 - Article

C2 - 20448093

AN - SCOPUS:77957058329

VL - 182

SP - 446

EP - 454

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

SN - 1073-449X

IS - 4

ER -