Chromosome aberrations in desmoid tumors Trisomy 8 may be a predictor of recurrence

Jonathan A. Fletcher, Rizwan C. Naeem, Sheng Xiao, Joseph M. Corson

Research output: Contribution to journalArticle

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Abstract

Cytogenetic analyses of short-term cultures revealed clonal chromosome aberrations in 6 of 13 desmoid tumors. These aberrations included two consistent events, trisomy 8 (n = 4) and trisomy 20 (n = 3), which have not been reported previously in desmoid tumors. Because trisomy 8 was found in two recurrent desmoid tumors, we used fluorescent in situ hybridization (FISH) methodology to evaluate chromosome 8 in 25 paraffin-embedded and frozen desmoid specimens. The FISH studies demonstrated that both patients with cytogenetic trisomy 8 at the time of recurrence also had had trisomy 8 in primary tumors 4 years earlier. The proportion of trisomy 8 cells in these cases did not change substantially between original diagnosis and recurrence. The FISH studies also revealed trisomy 8 in one recurrent desmoid tumor which had been cytogenetically unremarkable and revealed trisomy 8 in one recurrent desmoid that had not been karyotyped. Four of six patients with trisomy 8 had been followed for more than 1 year, and the desmoid tumors in each of these 4 patients recurred. By contrast, recurrence was noted in only 2 of 17 patients whose desmoid tumors lacked trisomy 8. Our findings demonstrate that trisomy 8 and trisomy 20 are nonrandom aberrations in desmoid tumors. Trisomy 8 appears to be associated with an increased risk of recurrence.

Original languageEnglish (US)
Pages (from-to)139-143
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume79
Issue number2
DOIs
StatePublished - 1995
Externally publishedYes

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Aggressive Fibromatosis
Chromosome Aberrations
Recurrence
Neoplasms
Fluorescence In Situ Hybridization
Trisomy Chromosome 8
Chromosomes, Human, Pair 8
Cytogenetic Analysis
Cytogenetics
Paraffin

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Chromosome aberrations in desmoid tumors Trisomy 8 may be a predictor of recurrence. / Fletcher, Jonathan A.; Naeem, Rizwan C.; Xiao, Sheng; Corson, Joseph M.

In: Cancer Genetics and Cytogenetics, Vol. 79, No. 2, 1995, p. 139-143.

Research output: Contribution to journalArticle

Fletcher, Jonathan A. ; Naeem, Rizwan C. ; Xiao, Sheng ; Corson, Joseph M. / Chromosome aberrations in desmoid tumors Trisomy 8 may be a predictor of recurrence. In: Cancer Genetics and Cytogenetics. 1995 ; Vol. 79, No. 2. pp. 139-143.
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