Chromosomal rearrangements in cancer: Detection and potential causal mechanisms

Paul Hasty, Cristina Montagna

Research output: Contribution to journalReview article

19 Scopus citations

Abstract

Many cancers exhibit chromosomal rearrangements. These rearrangements can be simple, involving a single balanced fusion that preserves the proper complement of genetic information, or complex with one or more fusions that disrupt this balance. Recent technological advances have improved our ability to detect and understand these rearrangements, leading to speculation about potential causal mechanisms such as defective DNA double strand break repair and faulty DNA replication. A better understanding of these potential cancer-causing mechanisms will lead to novel therapeutic regimens to fight cancer. This review describes technological advances in methods used to detect simple and complex chromosomal rearrangements, cancers that exhibit these rearrangements, potential mechanisms for rearrangement of chromosomes, and intervention strategies designed specifically against fusion gene products and causal DNA repair/synthesis pathways.

Original languageEnglish (US)
Article numbere29904
JournalMolecular and Cellular Oncology
Volume1
Issue number1
DOIs
Publication statusPublished - Jan 1 2014

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Keywords

  • chromosomal rearrangement
  • chromothripsis
  • DNA repair
  • oncogenesis
  • replication fork

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine

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