Chromosomal orientation of the lambda light chain locus: Vλ is proximal to Cλ in 22q11

B. S. Emanuel, L. A. Cannizzaro, I. Magrath, Y. Tsujimoto, P. C. Nowell, C. M. Croce

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Abstract

We have demonstrated that the chromosomal breakpoint at 22q11 of a Burkitt lymphoma cell line (PA682) with an 8;22 translocation interrupts the variable region of the lambda light chain locus. In these cells, all of the Cλ and some Vλ sequences translocate to the 8q+ chromosome whereas some Vλ sequences remain on the 22q-. These results indicate that the lambda light chain locus on the long arm of chromosome 22 is oriented such that Vλ is proximal to Cλ.

Original languageEnglish (US)
Pages (from-to)381-387
Number of pages7
JournalNucleic acids research
Volume13
Issue number2
DOIs
StatePublished - Jan 25 1985

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ASJC Scopus subject areas

  • Genetics

Cite this

Emanuel, B. S., Cannizzaro, L. A., Magrath, I., Tsujimoto, Y., Nowell, P. C., & Croce, C. M. (1985). Chromosomal orientation of the lambda light chain locus: Vλ is proximal to Cλ in 22q11. Nucleic acids research, 13(2), 381-387. https://doi.org/10.1093/nar/13.2.381