@article{3d59cbccd58847e39814eade481c77fb,
title = "Chromosomal orientation of the lambda light chain locus: Vλ is proximal to Cλ in 22q11",
abstract = "We have demonstrated that the chromosomal breakpoint at 22q11 of a Burkitt lymphoma cell line (PA682) with an 8;22 translocation interrupts the variable region of the lambda light chain locus. In these cells, all of the Cλ and some Vλ sequences translocate to the 8q+ chromosome whereas some Vλ sequences remain on the 22q-. These results indicate that the lambda light chain locus on the long arm of chromosome 22 is oriented such that Vλ is proximal to Cλ.",
author = "Emanuel, {B. S.} and Cannizzaro, {L. A.} and I. Magrath and Y. Tsujimoto and Nowell, {P. C.} and Croce, {C. M.}",
note = "Funding Information: ACKNOWLEDGMENT The authors wish to thank Kathleen Reinersmann for preparation of the manuscript. These studies were supported by National Institutes of Health Grants GM 32592 to the University of Pennsylvania Human Genetics Center (BSE), LC was supported by GM 07511, a training grant and National Cancer Institute, CA 16685 and CA 36521 (CMC).",
year = "1985",
month = jan,
day = "25",
doi = "10.1093/nar/13.2.381",
language = "English (US)",
volume = "13",
pages = "381--387",
journal = "Nucleic Acids Research",
issn = "0305-1048",
publisher = "Oxford University Press",
number = "2",
}