Abstract
We have demonstrated that the chromosomal breakpoint at 22q11 of a Burkitt lymphoma cell line (PA682) with an 8;22 translocation interrupts the variable region of the lambda light chain locus. In these cells, all of the Cλ and some Vλ sequences translocate to the 8q+ chromosome whereas some Vλ sequences remain on the 22q-. These results indicate that the lambda light chain locus on the long arm of chromosome 22 is oriented such that Vλ is proximal to Cλ.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 381-387 |
| Number of pages | 7 |
| Journal | Nucleic Acids Research |
| Volume | 13 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 25 1985 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Statistics, Probability and Uncertainty
- Applied Mathematics
- Health, Toxicology and Mutagenesis
- Toxicology
- Genetics(clinical)
- Genetics
Cite this
Chromosomal orientation of the lambda light chain locus : Vλ is proximal to Cλ in 22q11. / Emanuel, B. S.; Cannizzaro, L. A.; Magrath, I.; Tsujimoto, Y.; Nowell, P. C.; Croce, C. M.
In: Nucleic Acids Research, Vol. 13, No. 2, 25.01.1985, p. 381-387.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chromosomal orientation of the lambda light chain locus
T2 - Vλ is proximal to Cλ in 22q11
AU - Emanuel, B. S.
AU - Cannizzaro, L. A.
AU - Magrath, I.
AU - Tsujimoto, Y.
AU - Nowell, P. C.
AU - Croce, C. M.
PY - 1985/1/25
Y1 - 1985/1/25
N2 - We have demonstrated that the chromosomal breakpoint at 22q11 of a Burkitt lymphoma cell line (PA682) with an 8;22 translocation interrupts the variable region of the lambda light chain locus. In these cells, all of the Cλ and some Vλ sequences translocate to the 8q+ chromosome whereas some Vλ sequences remain on the 22q-. These results indicate that the lambda light chain locus on the long arm of chromosome 22 is oriented such that Vλ is proximal to Cλ.
AB - We have demonstrated that the chromosomal breakpoint at 22q11 of a Burkitt lymphoma cell line (PA682) with an 8;22 translocation interrupts the variable region of the lambda light chain locus. In these cells, all of the Cλ and some Vλ sequences translocate to the 8q+ chromosome whereas some Vλ sequences remain on the 22q-. These results indicate that the lambda light chain locus on the long arm of chromosome 22 is oriented such that Vλ is proximal to Cλ.
UR - http://www.scopus.com/inward/record.url?scp=0022431846&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022431846&partnerID=8YFLogxK
U2 - 10.1093/nar/13.2.381
DO - 10.1093/nar/13.2.381
M3 - Article
C2 - 3923432
AN - SCOPUS:0022431846
VL - 13
SP - 381
EP - 387
JO - Nucleic Acids Research
JF - Nucleic Acids Research
SN - 0305-1048
IS - 2
ER -