Chromosomal orientation of the lambda light chain locus: Vλ is proximal to Cλ in 22q11

B. S. Emanuel, L. A. Cannizzaro, I. Magrath, Y. Tsujimoto, P. C. Nowell, C. M. Croce

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

We have demonstrated that the chromosomal breakpoint at 22q11 of a Burkitt lymphoma cell line (PA682) with an 8;22 translocation interrupts the variable region of the lambda light chain locus. In these cells, all of the Cλ and some Vλ sequences translocate to the 8q+ chromosome whereas some Vλ sequences remain on the 22q-. These results indicate that the lambda light chain locus on the long arm of chromosome 22 is oriented such that Vλ is proximal to Cλ.

Original languageEnglish (US)
Pages (from-to)381-387
Number of pages7
JournalNucleic Acids Research
Volume13
Issue number2
DOIs
StatePublished - Jan 25 1985
Externally publishedYes

Fingerprint

Chromosomes
Chromosome
Locus
Light
Chromosomes, Human, Pair 22
Burkitt Lymphoma
Translocation
Cell
Cells
Cell Line
Line
Lymphoma
Cell line

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Health, Toxicology and Mutagenesis
  • Toxicology
  • Genetics(clinical)
  • Genetics

Cite this

Emanuel, B. S., Cannizzaro, L. A., Magrath, I., Tsujimoto, Y., Nowell, P. C., & Croce, C. M. (1985). Chromosomal orientation of the lambda light chain locus: Vλ is proximal to Cλ in 22q11. Nucleic Acids Research, 13(2), 381-387. https://doi.org/10.1093/nar/13.2.381

Chromosomal orientation of the lambda light chain locus : Vλ is proximal to Cλ in 22q11. / Emanuel, B. S.; Cannizzaro, L. A.; Magrath, I.; Tsujimoto, Y.; Nowell, P. C.; Croce, C. M.

In: Nucleic Acids Research, Vol. 13, No. 2, 25.01.1985, p. 381-387.

Research output: Contribution to journalArticle

Emanuel, BS, Cannizzaro, LA, Magrath, I, Tsujimoto, Y, Nowell, PC & Croce, CM 1985, 'Chromosomal orientation of the lambda light chain locus: Vλ is proximal to Cλ in 22q11', Nucleic Acids Research, vol. 13, no. 2, pp. 381-387. https://doi.org/10.1093/nar/13.2.381
Emanuel BS, Cannizzaro LA, Magrath I, Tsujimoto Y, Nowell PC, Croce CM. Chromosomal orientation of the lambda light chain locus: Vλ is proximal to Cλ in 22q11. Nucleic Acids Research. 1985 Jan 25;13(2):381-387. https://doi.org/10.1093/nar/13.2.381
Emanuel, B. S. ; Cannizzaro, L. A. ; Magrath, I. ; Tsujimoto, Y. ; Nowell, P. C. ; Croce, C. M. / Chromosomal orientation of the lambda light chain locus : Vλ is proximal to Cλ in 22q11. In: Nucleic Acids Research. 1985 ; Vol. 13, No. 2. pp. 381-387.
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