Chromosomal orientation of the lambda light chain locus: Vλ is proximal to Cλ in 22q11

B. S. Emanuel; L. A. Cannizzaro; I. Magrath; Y. Tsujimoto; P. C. Nowell; C. M. Croce

doi:10.1093/nar/13.2.381

Chromosomal orientation of the lambda light chain locus: Vλ is proximal to Cλ in 22q11

B. S. Emanuel, L. A. Cannizzaro, I. Magrath, Y. Tsujimoto, P. C. Nowell, C. M. Croce

Pathology

Research output: Contribution to journal › Article

22 Scopus citations

Abstract

We have demonstrated that the chromosomal breakpoint at 22q11 of a Burkitt lymphoma cell line (PA682) with an 8;22 translocation interrupts the variable region of the lambda light chain locus. In these cells, all of the Cλ and some Vλ sequences translocate to the 8q⁺ chromosome whereas some Vλ sequences remain on the 22q^-. These results indicate that the lambda light chain locus on the long arm of chromosome 22 is oriented such that Vλ is proximal to Cλ.

Original language	English (US)
Pages (from-to)	381-387
Number of pages	7
Journal	Nucleic acids research
Volume	13
Issue number	2
DOIs	https://doi.org/10.1093/nar/13.2.381
State	Published - Jan 25 1985

Fingerprint

ASJC Scopus subject areas

Genetics

Cite this

Emanuel, B. S., Cannizzaro, L. A., Magrath, I., Tsujimoto, Y., Nowell, P. C., & Croce, C. M. (1985). Chromosomal orientation of the lambda light chain locus: Vλ is proximal to Cλ in 22q11. Nucleic acids research, 13(2), 381-387. https://doi.org/10.1093/nar/13.2.381

@article{3d59cbccd58847e39814eade481c77fb,

title = "Chromosomal orientation of the lambda light chain locus: Vλ is proximal to Cλ in 22q11",

abstract = "We have demonstrated that the chromosomal breakpoint at 22q11 of a Burkitt lymphoma cell line (PA682) with an 8;22 translocation interrupts the variable region of the lambda light chain locus. In these cells, all of the Cλ and some Vλ sequences translocate to the 8q+ chromosome whereas some Vλ sequences remain on the 22q-. These results indicate that the lambda light chain locus on the long arm of chromosome 22 is oriented such that Vλ is proximal to Cλ.",

author = "Emanuel, {B. S.} and Cannizzaro, {L. A.} and I. Magrath and Y. Tsujimoto and Nowell, {P. C.} and Croce, {C. M.}",

year = "1985",

month = jan

day = "25",

doi = "10.1093/nar/13.2.381",

language = "English (US)",

volume = "13",

pages = "381--387",

journal = "Nucleic Acids Research",

issn = "0305-1048",

publisher = "Oxford University Press",

number = "2",

}

TY - JOUR

T1 - Chromosomal orientation of the lambda light chain locus

T2 - Vλ is proximal to Cλ in 22q11

AU - Emanuel, B. S.

AU - Cannizzaro, L. A.

AU - Magrath, I.

AU - Tsujimoto, Y.

AU - Nowell, P. C.

AU - Croce, C. M.

PY - 1985/1/25

Y1 - 1985/1/25

N2 - We have demonstrated that the chromosomal breakpoint at 22q11 of a Burkitt lymphoma cell line (PA682) with an 8;22 translocation interrupts the variable region of the lambda light chain locus. In these cells, all of the Cλ and some Vλ sequences translocate to the 8q+ chromosome whereas some Vλ sequences remain on the 22q-. These results indicate that the lambda light chain locus on the long arm of chromosome 22 is oriented such that Vλ is proximal to Cλ.

AB - We have demonstrated that the chromosomal breakpoint at 22q11 of a Burkitt lymphoma cell line (PA682) with an 8;22 translocation interrupts the variable region of the lambda light chain locus. In these cells, all of the Cλ and some Vλ sequences translocate to the 8q+ chromosome whereas some Vλ sequences remain on the 22q-. These results indicate that the lambda light chain locus on the long arm of chromosome 22 is oriented such that Vλ is proximal to Cλ.

UR - http://www.scopus.com/inward/record.url?scp=0022431846&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022431846&partnerID=8YFLogxK

U2 - 10.1093/nar/13.2.381

DO - 10.1093/nar/13.2.381

M3 - Article

C2 - 3923432

AN - SCOPUS:0022431846

VL - 13

SP - 381

EP - 387

JO - Nucleic Acids Research

JF - Nucleic Acids Research

SN - 0305-1048

IS - 2

ER -

Access to Document

10.1093/nar/13.2.381