Chromosomal orientation of the lambda light chain locus

Vλ is proximal to Cλ in 22q11

B. S. Emanuel, L. A. Cannizzaro, I. Magrath, Y. Tsujimoto, P. C. Nowell, C. M. Croce

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

We have demonstrated that the chromosomal breakpoint at 22q11 of a Burkitt lymphoma cell line (PA682) with an 8;22 translocation interrupts the variable region of the lambda light chain locus. In these cells, all of the Cλ and some Vλ sequences translocate to the 8q+ chromosome whereas some Vλ sequences remain on the 22q-. These results indicate that the lambda light chain locus on the long arm of chromosome 22 is oriented such that Vλ is proximal to Cλ.

Original languageEnglish (US)
Pages (from-to)381-387
Number of pages7
JournalNucleic Acids Research
Volume13
Issue number2
DOIs
StatePublished - Jan 25 1985
Externally publishedYes

Fingerprint

Chromosomes
Chromosome
Locus
Light
Chromosomes, Human, Pair 22
Burkitt Lymphoma
Translocation
Cell
Cells
Cell Line
Line
Lymphoma
Cell line

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Health, Toxicology and Mutagenesis
  • Toxicology
  • Genetics(clinical)
  • Genetics

Cite this

Emanuel, B. S., Cannizzaro, L. A., Magrath, I., Tsujimoto, Y., Nowell, P. C., & Croce, C. M. (1985). Chromosomal orientation of the lambda light chain locus: Vλ is proximal to Cλ in 22q11. Nucleic Acids Research, 13(2), 381-387. https://doi.org/10.1093/nar/13.2.381

Chromosomal orientation of the lambda light chain locus : Vλ is proximal to Cλ in 22q11. / Emanuel, B. S.; Cannizzaro, L. A.; Magrath, I.; Tsujimoto, Y.; Nowell, P. C.; Croce, C. M.

In: Nucleic Acids Research, Vol. 13, No. 2, 25.01.1985, p. 381-387.

Research output: Contribution to journalArticle

Emanuel, BS, Cannizzaro, LA, Magrath, I, Tsujimoto, Y, Nowell, PC & Croce, CM 1985, 'Chromosomal orientation of the lambda light chain locus: Vλ is proximal to Cλ in 22q11', Nucleic Acids Research, vol. 13, no. 2, pp. 381-387. https://doi.org/10.1093/nar/13.2.381
Emanuel BS, Cannizzaro LA, Magrath I, Tsujimoto Y, Nowell PC, Croce CM. Chromosomal orientation of the lambda light chain locus: Vλ is proximal to Cλ in 22q11. Nucleic Acids Research. 1985 Jan 25;13(2):381-387. https://doi.org/10.1093/nar/13.2.381
Emanuel, B. S. ; Cannizzaro, L. A. ; Magrath, I. ; Tsujimoto, Y. ; Nowell, P. C. ; Croce, C. M. / Chromosomal orientation of the lambda light chain locus : Vλ is proximal to Cλ in 22q11. In: Nucleic Acids Research. 1985 ; Vol. 13, No. 2. pp. 381-387.
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