Chromosomal orientation of the lambda light chain locus: Vλ is proximal to Cλ in 22q11

B. S. Emanuel; L. A. Cannizzaro; I. Magrath; Y. Tsujimoto; P. C. Nowell; C. M. Croce

doi:10.1093/nar/13.2.381

Chromosomal orientation of the lambda light chain locus: Vλ is proximal to Cλ in 22q11

B. S. Emanuel, L. A. Cannizzaro, I. Magrath, Y. Tsujimoto, P. C. Nowell, C. M. Croce

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

We have demonstrated that the chromosomal breakpoint at 22q11 of a Burkitt lymphoma cell line (PA682) with an 8;22 translocation interrupts the variable region of the lambda light chain locus. In these cells, all of the Cλ and some Vλ sequences translocate to the 8q⁺ chromosome whereas some Vλ sequences remain on the 22q^-. These results indicate that the lambda light chain locus on the long arm of chromosome 22 is oriented such that Vλ is proximal to Cλ.

Original language	English (US)
Pages (from-to)	381-387
Number of pages	7
Journal	Nucleic acids research
Volume	13
Issue number	2
DOIs	https://doi.org/10.1093/nar/13.2.381
State	Published - Jan 25 1985
Externally published	Yes

ASJC Scopus subject areas

Genetics

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title = "Chromosomal orientation of the lambda light chain locus: Vλ is proximal to Cλ in 22q11",

abstract = "We have demonstrated that the chromosomal breakpoint at 22q11 of a Burkitt lymphoma cell line (PA682) with an 8;22 translocation interrupts the variable region of the lambda light chain locus. In these cells, all of the Cλ and some Vλ sequences translocate to the 8q+ chromosome whereas some Vλ sequences remain on the 22q-. These results indicate that the lambda light chain locus on the long arm of chromosome 22 is oriented such that Vλ is proximal to Cλ.",

author = "Emanuel, {B. S.} and Cannizzaro, {L. A.} and I. Magrath and Y. Tsujimoto and Nowell, {P. C.} and Croce, {C. M.}",

note = "Funding Information: ACKNOWLEDGMENT The authors wish to thank Kathleen Reinersmann for preparation of the manuscript. These studies were supported by National Institutes of Health Grants GM 32592 to the University of Pennsylvania Human Genetics Center (BSE), LC was supported by GM 07511, a training grant and National Cancer Institute, CA 16685 and CA 36521 (CMC).",

year = "1985",

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doi = "10.1093/nar/13.2.381",

language = "English (US)",

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T1 - Chromosomal orientation of the lambda light chain locus

T2 - Vλ is proximal to Cλ in 22q11

AU - Emanuel, B. S.

AU - Cannizzaro, L. A.

AU - Magrath, I.

AU - Tsujimoto, Y.

AU - Nowell, P. C.

AU - Croce, C. M.

N1 - Funding Information: ACKNOWLEDGMENT The authors wish to thank Kathleen Reinersmann for preparation of the manuscript. These studies were supported by National Institutes of Health Grants GM 32592 to the University of Pennsylvania Human Genetics Center (BSE), LC was supported by GM 07511, a training grant and National Cancer Institute, CA 16685 and CA 36521 (CMC).

PY - 1985/1/25

Y1 - 1985/1/25

N2 - We have demonstrated that the chromosomal breakpoint at 22q11 of a Burkitt lymphoma cell line (PA682) with an 8;22 translocation interrupts the variable region of the lambda light chain locus. In these cells, all of the Cλ and some Vλ sequences translocate to the 8q+ chromosome whereas some Vλ sequences remain on the 22q-. These results indicate that the lambda light chain locus on the long arm of chromosome 22 is oriented such that Vλ is proximal to Cλ.

AB - We have demonstrated that the chromosomal breakpoint at 22q11 of a Burkitt lymphoma cell line (PA682) with an 8;22 translocation interrupts the variable region of the lambda light chain locus. In these cells, all of the Cλ and some Vλ sequences translocate to the 8q+ chromosome whereas some Vλ sequences remain on the 22q-. These results indicate that the lambda light chain locus on the long arm of chromosome 22 is oriented such that Vλ is proximal to Cλ.

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Chromosomal orientation of the lambda light chain locus: Vλ is proximal to Cλ in 22q11

Abstract

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