Chromosomal mapping of the genes GPRK5 and GPRK6 encoding G protein-coupled receptor kinases GRK5 and GRK6

F. Bullrich, T. Druck, P. Kunapuli, J. Gomez, K. W. Gripp, B. Schlegelberger, J. Lasota, M. Aronson, L. A. Cannizzaro, K. Huebner, Jeffrey L. Benovic

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

G protein-coupled receptor kinases (GRKs) play an important role in phosphorylating and regulating the activity of a variety of G protein-coupled receptors. Chromosomal mapping of the human genes for the two most recently identified members of the GRK family, GRK5 (GPRK5) and GRK6 (GPRK6), was accomplished by correlation of the presence of the GPRK5 and GPRK6 loci with specific chromosome regions in a rodent-human hybrid panel. These analyses revealed that GPRK5 maps to chromosome region 10q24→qter while GPRK6 maps to 5q35. A GPRK6 related locus maps to 13pter→q21.

Original languageEnglish (US)
Pages (from-to)250-254
Number of pages5
JournalCytogenetic and Genome Research
Volume70
Issue number3-4
DOIs
StatePublished - Jan 1 1995

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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    Bullrich, F., Druck, T., Kunapuli, P., Gomez, J., Gripp, K. W., Schlegelberger, B., Lasota, J., Aronson, M., Cannizzaro, L. A., Huebner, K., & Benovic, J. L. (1995). Chromosomal mapping of the genes GPRK5 and GPRK6 encoding G protein-coupled receptor kinases GRK5 and GRK6. Cytogenetic and Genome Research, 70(3-4), 250-254. https://doi.org/10.1159/000134045