Chromosomal localization of the human genes for lipocortin I and lipocortin II

K. Huebner, L. A. Cannizzaro, A. L. Frey, B. K. Hecht, F. Hecht, C. M. Croce, B. P. Wallner

Research output: Contribution to journalArticle

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Abstract

The human genes which code for Lipocortin I and Lipocortin II, proteins that inhibit phospholipase A2 (PLA2) activity, have been regionally localized in the human genome by chromosomal in situ hybridization and segregation analysis in somatic cell hybrids using cDNA clones for Lipocortin I and II. Lipocortin I, the 35 kd substrate for the epidermal growth factor (EGF) receptor/kinase, maps to chromosome region 9q11->q22. The Lipocortin II cDNA probe detects at least four independently segregating loci which map to human chromosome regions 4q21-q31.1, 9pter-q34 proximal to c-abl, 10q proximal to 10q24 and 15q21-q22 proximal to the 15q22 translocation breakpoint characteristic of acute promyelocytic leukemia (APL). Thus, Lipocortin I and one locus detected by Lipocortin II cDNA are syntenic on chromosome 9; one Lipocortin II locus is perhaps not far from the genes for EGF and IL-2 on 4q; and another of the Lipocortin II loci is on 15q, perhaps not far from the APL breakpoint.

Original languageEnglish (US)
Pages (from-to)299-310
Number of pages12
JournalOncogene Research
Volume2
Issue number4
StatePublished - 1988
Externally publishedYes

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Annexin A2
Annexin A1
Genes
Acute Promyelocytic Leukemia
Complementary DNA
Chromosomes, Human, Pair 9
Hybrid Cells
Phospholipases A2
Human Chromosomes
Human Genome
Epidermal Growth Factor Receptor
Epidermal Growth Factor
Interleukin-2
In Situ Hybridization
Clone Cells
Chromosomes

ASJC Scopus subject areas

  • Cancer Research

Cite this

Huebner, K., Cannizzaro, L. A., Frey, A. L., Hecht, B. K., Hecht, F., Croce, C. M., & Wallner, B. P. (1988). Chromosomal localization of the human genes for lipocortin I and lipocortin II. Oncogene Research, 2(4), 299-310.

Chromosomal localization of the human genes for lipocortin I and lipocortin II. / Huebner, K.; Cannizzaro, L. A.; Frey, A. L.; Hecht, B. K.; Hecht, F.; Croce, C. M.; Wallner, B. P.

In: Oncogene Research, Vol. 2, No. 4, 1988, p. 299-310.

Research output: Contribution to journalArticle

Huebner, K, Cannizzaro, LA, Frey, AL, Hecht, BK, Hecht, F, Croce, CM & Wallner, BP 1988, 'Chromosomal localization of the human genes for lipocortin I and lipocortin II', Oncogene Research, vol. 2, no. 4, pp. 299-310.
Huebner K, Cannizzaro LA, Frey AL, Hecht BK, Hecht F, Croce CM et al. Chromosomal localization of the human genes for lipocortin I and lipocortin II. Oncogene Research. 1988;2(4):299-310.
Huebner, K. ; Cannizzaro, L. A. ; Frey, A. L. ; Hecht, B. K. ; Hecht, F. ; Croce, C. M. ; Wallner, B. P. / Chromosomal localization of the human genes for lipocortin I and lipocortin II. In: Oncogene Research. 1988 ; Vol. 2, No. 4. pp. 299-310.
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