CHROMOSOMENANALYSE UND TdT-BESTIMMUNG: WICHTIGE PROGNOSTISCHE PARAMETER DER BLASTENKRISE DER CHRONISCHEN MYELOISCHEN LEUKAMIE

Translated title of the contribution: Chromosomal analysis and TdT-determination: Important prognostic parameters in CML blast crisis

J. D. Schwarzmeier, O. Haas, Elisabeth M. Paietta, P. Fischer

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

To detect karyotype changes during the chronic phase of CML, 31 mostly Ph1-positive patients were followed cytogenetically over a period of 3 years. Newly emerging abnormalities, e.g. second Ph1-chromosone, iso17q, trisomy 8, could be correlated with clinical and hematological characteristics of the course of the disease if they constituted the first additional chromosomal change. In 54 patients with suspected or established blast crisis, TdT determinations were performed. Out of 27 patients with verified blast crisis, 6 showed markedly elevated enzyme activities in the leukemic blast cells. These patients proved to be very sensitive to cytostatic therapy with prednisone and vincristine. The continuous observation of TdT levels enabled us to initiate a controlled and, with respect to the quality of life, a less toxic therapy. Our data indicate that serial chromosomal analyses and TdT determinations are of great value in predicting prognosis and therapeutic responsiveness in CML.

Original languageGerman
Pages (from-to)514-520
Number of pages7
JournalWiener Klinische Wochenschrift
Volume94
Issue number19
StatePublished - 1982
Externally publishedYes

Fingerprint

Blast Crisis
Poisons
Cytostatic Agents
Vincristine
Prednisone
Karyotype
Therapeutics
Quality of Life
Observation
Enzymes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

CHROMOSOMENANALYSE UND TdT-BESTIMMUNG : WICHTIGE PROGNOSTISCHE PARAMETER DER BLASTENKRISE DER CHRONISCHEN MYELOISCHEN LEUKAMIE. / Schwarzmeier, J. D.; Haas, O.; Paietta, Elisabeth M.; Fischer, P.

In: Wiener Klinische Wochenschrift, Vol. 94, No. 19, 1982, p. 514-520.

Research output: Contribution to journalArticle

@article{10c4456ade7c4ea7bdf49eceff47b6f3,
title = "CHROMOSOMENANALYSE UND TdT-BESTIMMUNG: WICHTIGE PROGNOSTISCHE PARAMETER DER BLASTENKRISE DER CHRONISCHEN MYELOISCHEN LEUKAMIE",
abstract = "To detect karyotype changes during the chronic phase of CML, 31 mostly Ph1-positive patients were followed cytogenetically over a period of 3 years. Newly emerging abnormalities, e.g. second Ph1-chromosone, iso17q, trisomy 8, could be correlated with clinical and hematological characteristics of the course of the disease if they constituted the first additional chromosomal change. In 54 patients with suspected or established blast crisis, TdT determinations were performed. Out of 27 patients with verified blast crisis, 6 showed markedly elevated enzyme activities in the leukemic blast cells. These patients proved to be very sensitive to cytostatic therapy with prednisone and vincristine. The continuous observation of TdT levels enabled us to initiate a controlled and, with respect to the quality of life, a less toxic therapy. Our data indicate that serial chromosomal analyses and TdT determinations are of great value in predicting prognosis and therapeutic responsiveness in CML.",
author = "Schwarzmeier, {J. D.} and O. Haas and Paietta, {Elisabeth M.} and P. Fischer",
year = "1982",
language = "German",
volume = "94",
pages = "514--520",
journal = "Wiener Klinische Wochenschrift",
issn = "0043-5325",
publisher = "Springer Wien",
number = "19",

}

TY - JOUR

T1 - CHROMOSOMENANALYSE UND TdT-BESTIMMUNG

T2 - WICHTIGE PROGNOSTISCHE PARAMETER DER BLASTENKRISE DER CHRONISCHEN MYELOISCHEN LEUKAMIE

AU - Schwarzmeier, J. D.

AU - Haas, O.

AU - Paietta, Elisabeth M.

AU - Fischer, P.

PY - 1982

Y1 - 1982

N2 - To detect karyotype changes during the chronic phase of CML, 31 mostly Ph1-positive patients were followed cytogenetically over a period of 3 years. Newly emerging abnormalities, e.g. second Ph1-chromosone, iso17q, trisomy 8, could be correlated with clinical and hematological characteristics of the course of the disease if they constituted the first additional chromosomal change. In 54 patients with suspected or established blast crisis, TdT determinations were performed. Out of 27 patients with verified blast crisis, 6 showed markedly elevated enzyme activities in the leukemic blast cells. These patients proved to be very sensitive to cytostatic therapy with prednisone and vincristine. The continuous observation of TdT levels enabled us to initiate a controlled and, with respect to the quality of life, a less toxic therapy. Our data indicate that serial chromosomal analyses and TdT determinations are of great value in predicting prognosis and therapeutic responsiveness in CML.

AB - To detect karyotype changes during the chronic phase of CML, 31 mostly Ph1-positive patients were followed cytogenetically over a period of 3 years. Newly emerging abnormalities, e.g. second Ph1-chromosone, iso17q, trisomy 8, could be correlated with clinical and hematological characteristics of the course of the disease if they constituted the first additional chromosomal change. In 54 patients with suspected or established blast crisis, TdT determinations were performed. Out of 27 patients with verified blast crisis, 6 showed markedly elevated enzyme activities in the leukemic blast cells. These patients proved to be very sensitive to cytostatic therapy with prednisone and vincristine. The continuous observation of TdT levels enabled us to initiate a controlled and, with respect to the quality of life, a less toxic therapy. Our data indicate that serial chromosomal analyses and TdT determinations are of great value in predicting prognosis and therapeutic responsiveness in CML.

UR - http://www.scopus.com/inward/record.url?scp=0019989876&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019989876&partnerID=8YFLogxK

M3 - Article

C2 - 6760560

AN - SCOPUS:0019989876

VL - 94

SP - 514

EP - 520

JO - Wiener Klinische Wochenschrift

JF - Wiener Klinische Wochenschrift

SN - 0043-5325

IS - 19

ER -