Chondroitin sulphate and peritoneal permeability.

A. Breborowicz, K. Wieczorowska, J. Knapowski, L. Martis, K. D. Serkes, D. G. Oreopoulos

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Abstract

We studied the effect of chronic intraperitoneal (ip) infusion of saline supplemented with the glycosaminoglycan-chondroitin sulphate 0.1% on the permeability and peroxidation of the peritoneal membrane in rats and compared this with the effect of saline infusion alone. Animals treated with chondroitin sulphate had a higher net ultrafiltration (uf), a slower glucose absorption from the dialysate and less trans-peritoneal loss of proteins. Chronic ip infusion of chondroitin sulphate reduced peroxidation of the peritoneum. These observations suggest that chondroitin may effect the peritoneal interstitium-an important barrier of fluid and solutes transport.

Original languageEnglish (US)
Pages (from-to)11-14
Number of pages4
JournalAdvances in peritoneal dialysis. Conference on Peritoneal Dialysis
Volume8
Publication statusPublished - 1992

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ASJC Scopus subject areas

  • Medicine(all)

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Breborowicz, A., Wieczorowska, K., Knapowski, J., Martis, L., Serkes, K. D., & Oreopoulos, D. G. (1992). Chondroitin sulphate and peritoneal permeability. Advances in peritoneal dialysis. Conference on Peritoneal Dialysis, 8, 11-14.