Chondroitin sulphate and peritoneal permeability.

A. Breborowicz, K. Wieczorowska, J. Knapowski, L. Martis, K. D. Serkes, D. G. Oreopoulos

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We studied the effect of chronic intraperitoneal (ip) infusion of saline supplemented with the glycosaminoglycan-chondroitin sulphate 0.1% on the permeability and peroxidation of the peritoneal membrane in rats and compared this with the effect of saline infusion alone. Animals treated with chondroitin sulphate had a higher net ultrafiltration (uf), a slower glucose absorption from the dialysate and less trans-peritoneal loss of proteins. Chronic ip infusion of chondroitin sulphate reduced peroxidation of the peritoneum. These observations suggest that chondroitin may effect the peritoneal interstitium-an important barrier of fluid and solutes transport.

Original languageEnglish (US)
Pages (from-to)11-14
Number of pages4
JournalAdvances in peritoneal dialysis. Conference on Peritoneal Dialysis
Volume8
StatePublished - 1992
Externally publishedYes

Fingerprint

Parenteral Infusions
Chondroitin Sulfates
Permeability
Chondroitin
Peritoneum
Dialysis Solutions
Ultrafiltration
Glucose
Membranes
Proteins
chondroitin sulfate glycosaminoglycan

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Breborowicz, A., Wieczorowska, K., Knapowski, J., Martis, L., Serkes, K. D., & Oreopoulos, D. G. (1992). Chondroitin sulphate and peritoneal permeability. Advances in peritoneal dialysis. Conference on Peritoneal Dialysis, 8, 11-14.

Chondroitin sulphate and peritoneal permeability. / Breborowicz, A.; Wieczorowska, K.; Knapowski, J.; Martis, L.; Serkes, K. D.; Oreopoulos, D. G.

In: Advances in peritoneal dialysis. Conference on Peritoneal Dialysis, Vol. 8, 1992, p. 11-14.

Research output: Contribution to journalArticle

Breborowicz, A, Wieczorowska, K, Knapowski, J, Martis, L, Serkes, KD & Oreopoulos, DG 1992, 'Chondroitin sulphate and peritoneal permeability.', Advances in peritoneal dialysis. Conference on Peritoneal Dialysis, vol. 8, pp. 11-14.
Breborowicz A, Wieczorowska K, Knapowski J, Martis L, Serkes KD, Oreopoulos DG. Chondroitin sulphate and peritoneal permeability. Advances in peritoneal dialysis. Conference on Peritoneal Dialysis. 1992;8:11-14.
Breborowicz, A. ; Wieczorowska, K. ; Knapowski, J. ; Martis, L. ; Serkes, K. D. ; Oreopoulos, D. G. / Chondroitin sulphate and peritoneal permeability. In: Advances in peritoneal dialysis. Conference on Peritoneal Dialysis. 1992 ; Vol. 8. pp. 11-14.
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