ChIP-chip analysis of neurexins and other candidate genes for addiction and neuropsychiatric disorders

Erika Pedrosa, Sashank Kaushik, Herbert M. Lachman

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Several addiction susceptibility genes have been mapped by linkage and genomewide association. However, functional alleles associated with disease risk have not been identified, with a few possible exceptions. In addition, little is known about the cis- and trans-acting factors involved in regulating their expression. To address these issues, we used a ChIP-chip approach to identify regulatory elements in fetal-brain targeting genes implicated in addiction and other neuropsychiatric conditions. Our data point to a number of putative regulatory elements, several of which, we show, are functionally significant. Many established or putative regulatory elements map near-diseaseassociated SNPs. These regions would be of interest to survey for patient-specific functional variants involved in disease susceptibility.

Original languageEnglish (US)
Pages (from-to)5-17
Number of pages13
JournalJournal of Neurogenetics
Volume24
Issue number1
DOIs
Publication statusPublished - 2010

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Keywords

  • Adhesion
  • Bipolar disorder
  • Chromatin immunoprecipitation
  • DRD2
  • Dopamine
  • Neurexin
  • Schizophrenia

ASJC Scopus subject areas

  • Genetics
  • Cellular and Molecular Neuroscience

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