Abstract
Several addiction susceptibility genes have been mapped by linkage and genomewide association. However, functional alleles associated with disease risk have not been identified, with a few possible exceptions. In addition, little is known about the cis- and trans-acting factors involved in regulating their expression. To address these issues, we used a ChIP-chip approach to identify regulatory elements in fetal-brain targeting genes implicated in addiction and other neuropsychiatric conditions. Our data point to a number of putative regulatory elements, several of which, we show, are functionally significant. Many established or putative regulatory elements map near-diseaseassociated SNPs. These regions would be of interest to survey for patient-specific functional variants involved in disease susceptibility.
Original language | English (US) |
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Pages (from-to) | 5-17 |
Number of pages | 13 |
Journal | Journal of Neurogenetics |
Volume | 24 |
Issue number | 1 |
DOIs | |
State | Published - 2010 |
Keywords
- Adhesion
- Bipolar disorder
- Chromatin immunoprecipitation
- DRD2
- Dopamine
- Neurexin
- Schizophrenia
ASJC Scopus subject areas
- Genetics
- Cellular and Molecular Neuroscience