Several addiction susceptibility genes have been mapped by linkage and genomewide association. However, functional alleles associated with disease risk have not been identified, with a few possible exceptions. In addition, little is known about the cis- and trans-acting factors involved in regulating their expression. To address these issues, we used a ChIP-chip approach to identify regulatory elements in fetal-brain targeting genes implicated in addiction and other neuropsychiatric conditions. Our data point to a number of putative regulatory elements, several of which, we show, are functionally significant. Many established or putative regulatory elements map near-diseaseassociated SNPs. These regions would be of interest to survey for patient-specific functional variants involved in disease susceptibility.
- Bipolar disorder
- Chromatin immunoprecipitation
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience