Abstract
The increasing prevalence of obesity in children seems to be associated with an increased prevalence of obstructive sleep apnea syndrome (OSAS) in children. Possible pathophysiological mechanisms contributing to this association include the following: adenotonsillar hypertrophy due to increased somatic growth, increased critical airway closing pressure, altered chest wall mechanics and abnormalities of ventilatory control. However, the details of these mechanisms and their interactions have not been elucidated. In addition, obesity and OSAS are both associated with metabolic syndrome, which is a constellation of features such as hypertension, insulin resistance, dyslipidemia, abdominal obesity and prothrombotic and proinflammatory states. There is some evidence that OSAS may contribute to the progression of metabolic syndrome with a potential for significant morbidity. The treatment of OSAS in obese children has not been standardized. Adenotonsillectomy is considered the primary intervention followed by continuous positive airway pressure treatment if OSAS persists. Other methods such as oral appliances, surgery, positional therapy and weight loss may be beneficial for individual subjects. The present review discusses these issues and suggests an approach to the management of obese children with snoring and possible OSAS.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 436-444 |
| Number of pages | 9 |
| Journal | Journal of Applied Physiology |
| Volume | 108 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 2010 |
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Keywords
- Metabolic syndrome
- Sleep-disordered breathing
ASJC Scopus subject areas
- Physiology
- Physiology (medical)
Cite this
Childhood obesity and obstructive sleep apnea syndrome. / Arens, Raanan; Muzumdar, Hiren.
In: Journal of Applied Physiology, Vol. 108, No. 2, 02.2010, p. 436-444.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Childhood obesity and obstructive sleep apnea syndrome
AU - Arens, Raanan
AU - Muzumdar, Hiren
PY - 2010/2
Y1 - 2010/2
N2 - The increasing prevalence of obesity in children seems to be associated with an increased prevalence of obstructive sleep apnea syndrome (OSAS) in children. Possible pathophysiological mechanisms contributing to this association include the following: adenotonsillar hypertrophy due to increased somatic growth, increased critical airway closing pressure, altered chest wall mechanics and abnormalities of ventilatory control. However, the details of these mechanisms and their interactions have not been elucidated. In addition, obesity and OSAS are both associated with metabolic syndrome, which is a constellation of features such as hypertension, insulin resistance, dyslipidemia, abdominal obesity and prothrombotic and proinflammatory states. There is some evidence that OSAS may contribute to the progression of metabolic syndrome with a potential for significant morbidity. The treatment of OSAS in obese children has not been standardized. Adenotonsillectomy is considered the primary intervention followed by continuous positive airway pressure treatment if OSAS persists. Other methods such as oral appliances, surgery, positional therapy and weight loss may be beneficial for individual subjects. The present review discusses these issues and suggests an approach to the management of obese children with snoring and possible OSAS.
AB - The increasing prevalence of obesity in children seems to be associated with an increased prevalence of obstructive sleep apnea syndrome (OSAS) in children. Possible pathophysiological mechanisms contributing to this association include the following: adenotonsillar hypertrophy due to increased somatic growth, increased critical airway closing pressure, altered chest wall mechanics and abnormalities of ventilatory control. However, the details of these mechanisms and their interactions have not been elucidated. In addition, obesity and OSAS are both associated with metabolic syndrome, which is a constellation of features such as hypertension, insulin resistance, dyslipidemia, abdominal obesity and prothrombotic and proinflammatory states. There is some evidence that OSAS may contribute to the progression of metabolic syndrome with a potential for significant morbidity. The treatment of OSAS in obese children has not been standardized. Adenotonsillectomy is considered the primary intervention followed by continuous positive airway pressure treatment if OSAS persists. Other methods such as oral appliances, surgery, positional therapy and weight loss may be beneficial for individual subjects. The present review discusses these issues and suggests an approach to the management of obese children with snoring and possible OSAS.
KW - Metabolic syndrome
KW - Sleep-disordered breathing
UR - http://www.scopus.com/inward/record.url?scp=75749087624&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=75749087624&partnerID=8YFLogxK
U2 - 10.1152/japplphysiol.00689.2009
DO - 10.1152/japplphysiol.00689.2009
M3 - Article
C2 - 19875714
AN - SCOPUS:75749087624
VL - 108
SP - 436
EP - 444
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
SN - 8750-7587
IS - 2
ER -