Childhood obesity and obstructive sleep apnea syndrome

Raanan Arens, Hiren Muzumdar

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

The increasing prevalence of obesity in children seems to be associated with an increased prevalence of obstructive sleep apnea syndrome (OSAS) in children. Possible pathophysiological mechanisms contributing to this association include the following: adenotonsillar hypertrophy due to increased somatic growth, increased critical airway closing pressure, altered chest wall mechanics and abnormalities of ventilatory control. However, the details of these mechanisms and their interactions have not been elucidated. In addition, obesity and OSAS are both associated with metabolic syndrome, which is a constellation of features such as hypertension, insulin resistance, dyslipidemia, abdominal obesity and prothrombotic and proinflammatory states. There is some evidence that OSAS may contribute to the progression of metabolic syndrome with a potential for significant morbidity. The treatment of OSAS in obese children has not been standardized. Adenotonsillectomy is considered the primary intervention followed by continuous positive airway pressure treatment if OSAS persists. Other methods such as oral appliances, surgery, positional therapy and weight loss may be beneficial for individual subjects. The present review discusses these issues and suggests an approach to the management of obese children with snoring and possible OSAS.

Original languageEnglish (US)
Pages (from-to)436-444
Number of pages9
JournalJournal of Applied Physiology
Volume108
Issue number2
DOIs
StatePublished - Feb 2010

Fingerprint

Pediatric Obesity
Obstructive Sleep Apnea
Snoring
Continuous Positive Airway Pressure
Abdominal Obesity
Oral Surgery
Thoracic Wall
Dyslipidemias
Mechanics
Hypertrophy
Insulin Resistance
Weight Loss
Therapeutics
Obesity
Hypertension
Morbidity
Pressure
Growth

Keywords

  • Metabolic syndrome
  • Sleep-disordered breathing

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Childhood obesity and obstructive sleep apnea syndrome. / Arens, Raanan; Muzumdar, Hiren.

In: Journal of Applied Physiology, Vol. 108, No. 2, 02.2010, p. 436-444.

Research output: Contribution to journalArticle

Arens, Raanan ; Muzumdar, Hiren. / Childhood obesity and obstructive sleep apnea syndrome. In: Journal of Applied Physiology. 2010 ; Vol. 108, No. 2. pp. 436-444.
@article{a7e7f5508ef046899416c7d1f5a05f45,
title = "Childhood obesity and obstructive sleep apnea syndrome",
abstract = "The increasing prevalence of obesity in children seems to be associated with an increased prevalence of obstructive sleep apnea syndrome (OSAS) in children. Possible pathophysiological mechanisms contributing to this association include the following: adenotonsillar hypertrophy due to increased somatic growth, increased critical airway closing pressure, altered chest wall mechanics and abnormalities of ventilatory control. However, the details of these mechanisms and their interactions have not been elucidated. In addition, obesity and OSAS are both associated with metabolic syndrome, which is a constellation of features such as hypertension, insulin resistance, dyslipidemia, abdominal obesity and prothrombotic and proinflammatory states. There is some evidence that OSAS may contribute to the progression of metabolic syndrome with a potential for significant morbidity. The treatment of OSAS in obese children has not been standardized. Adenotonsillectomy is considered the primary intervention followed by continuous positive airway pressure treatment if OSAS persists. Other methods such as oral appliances, surgery, positional therapy and weight loss may be beneficial for individual subjects. The present review discusses these issues and suggests an approach to the management of obese children with snoring and possible OSAS.",
keywords = "Metabolic syndrome, Sleep-disordered breathing",
author = "Raanan Arens and Hiren Muzumdar",
year = "2010",
month = "2",
doi = "10.1152/japplphysiol.00689.2009",
language = "English (US)",
volume = "108",
pages = "436--444",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "2",

}

TY - JOUR

T1 - Childhood obesity and obstructive sleep apnea syndrome

AU - Arens, Raanan

AU - Muzumdar, Hiren

PY - 2010/2

Y1 - 2010/2

N2 - The increasing prevalence of obesity in children seems to be associated with an increased prevalence of obstructive sleep apnea syndrome (OSAS) in children. Possible pathophysiological mechanisms contributing to this association include the following: adenotonsillar hypertrophy due to increased somatic growth, increased critical airway closing pressure, altered chest wall mechanics and abnormalities of ventilatory control. However, the details of these mechanisms and their interactions have not been elucidated. In addition, obesity and OSAS are both associated with metabolic syndrome, which is a constellation of features such as hypertension, insulin resistance, dyslipidemia, abdominal obesity and prothrombotic and proinflammatory states. There is some evidence that OSAS may contribute to the progression of metabolic syndrome with a potential for significant morbidity. The treatment of OSAS in obese children has not been standardized. Adenotonsillectomy is considered the primary intervention followed by continuous positive airway pressure treatment if OSAS persists. Other methods such as oral appliances, surgery, positional therapy and weight loss may be beneficial for individual subjects. The present review discusses these issues and suggests an approach to the management of obese children with snoring and possible OSAS.

AB - The increasing prevalence of obesity in children seems to be associated with an increased prevalence of obstructive sleep apnea syndrome (OSAS) in children. Possible pathophysiological mechanisms contributing to this association include the following: adenotonsillar hypertrophy due to increased somatic growth, increased critical airway closing pressure, altered chest wall mechanics and abnormalities of ventilatory control. However, the details of these mechanisms and their interactions have not been elucidated. In addition, obesity and OSAS are both associated with metabolic syndrome, which is a constellation of features such as hypertension, insulin resistance, dyslipidemia, abdominal obesity and prothrombotic and proinflammatory states. There is some evidence that OSAS may contribute to the progression of metabolic syndrome with a potential for significant morbidity. The treatment of OSAS in obese children has not been standardized. Adenotonsillectomy is considered the primary intervention followed by continuous positive airway pressure treatment if OSAS persists. Other methods such as oral appliances, surgery, positional therapy and weight loss may be beneficial for individual subjects. The present review discusses these issues and suggests an approach to the management of obese children with snoring and possible OSAS.

KW - Metabolic syndrome

KW - Sleep-disordered breathing

UR - http://www.scopus.com/inward/record.url?scp=75749087624&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=75749087624&partnerID=8YFLogxK

U2 - 10.1152/japplphysiol.00689.2009

DO - 10.1152/japplphysiol.00689.2009

M3 - Article

C2 - 19875714

AN - SCOPUS:75749087624

VL - 108

SP - 436

EP - 444

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 2

ER -