Childhood and adult exposure to secondhand tobacco smoke and cardiac structure and function: Results from Echo-SOL

Melissa Suzanne Burroughs Peña, Katrina Swett, Robert C. Kaplan, Krista Perreira, Martha Daviglus, Mayank M. Kansal, Jianwen Cai, Aida L. Giachello, Marc D. Gellman, Eric J. Velazquez, Carlos J. Rodriguez

Research output: Contribution to journalArticle

Abstract

Objective To describe the relationship of household secondhand smoke (SHS) exposure and cardiac structure and function. Methods Participants (n=1069; 68 % female; age 45-74 years) without history of tobacco use, coronary artery disease or severe valvular disease were included. Past childhood (starting at age <13 years), adolescent/adult and current exposure to household SHS was assessed. Survey linear regression analyses were used to model the relationship of SHS exposure and echocardiographic measures of cardiac structure and function, adjusting for covariates (age, sex, study site, alcohol use, physical activity and education). Results SHS exposure in childhood only was associated with reduced E/A velocity ratio (β=-0.06 (SE 0.02), p=0.008). SHS exposure in adolescence/adult only was associated with increased left ventricular ejection fraction (LVEF) (1.2 (0.6), p=0.04), left atrial volume index (1.7 (0.8), p=0.04) and decreased isovolumic relaxation time (-0.003 (0.002), p=0.03). SHS exposure in childhood and adolescence/adult was associated with worse left ventricular global longitudinal strain (LVGLS) (two-chamber) (0.8 (0.4), p= 0.049). Compared with individuals who do not live with a tobacco smoker, individuals who currently live with at least one tobacco smoker had reduced LVEF (-1.4 (0.6), p=0.02), LVGLS (average) (0.9 (0.40), p=0.03), medial E′ velocity (-0.5 (0.2), p=0.01), E/A ratio (-0.09 (0.03), p=0.003) and right ventricular fractional area change (-0.02 (0.01), p=0.01) with increased isovolumic relaxation time (0.006 (0.003), p=0.04). Conclusions Past and current household exposure to SHS was associated with abnormalities in cardiac systolic and diastolic function. Reducing household SHS exposure may be an opportunity for cardiac dysfunction prevention to reduce the risk of future clinical heart failure.

Original languageEnglish (US)
Article numbere000831
JournalOpen Heart
Volume5
Issue number2
DOIs
StatePublished - Jan 1 2018

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Tobacco Smoke Pollution
Tobacco
Stroke Volume
Physical Education and Training
Tobacco Use
Coronary Artery Disease
Linear Models
Heart Failure
Regression Analysis
Alcohols
Exercise

Keywords

  • echocardiography
  • epidemiology
  • heart failure
  • tobacco smoke pollution

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Childhood and adult exposure to secondhand tobacco smoke and cardiac structure and function : Results from Echo-SOL. / Peña, Melissa Suzanne Burroughs; Swett, Katrina; Kaplan, Robert C.; Perreira, Krista; Daviglus, Martha; Kansal, Mayank M.; Cai, Jianwen; Giachello, Aida L.; Gellman, Marc D.; Velazquez, Eric J.; Rodriguez, Carlos J.

In: Open Heart, Vol. 5, No. 2, e000831, 01.01.2018.

Research output: Contribution to journalArticle

Peña, MSB, Swett, K, Kaplan, RC, Perreira, K, Daviglus, M, Kansal, MM, Cai, J, Giachello, AL, Gellman, MD, Velazquez, EJ & Rodriguez, CJ 2018, 'Childhood and adult exposure to secondhand tobacco smoke and cardiac structure and function: Results from Echo-SOL', Open Heart, vol. 5, no. 2, e000831. https://doi.org/10.1136/openhrt-2018-000831
Peña, Melissa Suzanne Burroughs ; Swett, Katrina ; Kaplan, Robert C. ; Perreira, Krista ; Daviglus, Martha ; Kansal, Mayank M. ; Cai, Jianwen ; Giachello, Aida L. ; Gellman, Marc D. ; Velazquez, Eric J. ; Rodriguez, Carlos J. / Childhood and adult exposure to secondhand tobacco smoke and cardiac structure and function : Results from Echo-SOL. In: Open Heart. 2018 ; Vol. 5, No. 2.
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abstract = "Objective To describe the relationship of household secondhand smoke (SHS) exposure and cardiac structure and function. Methods Participants (n=1069; 68 {\%} female; age 45-74 years) without history of tobacco use, coronary artery disease or severe valvular disease were included. Past childhood (starting at age <13 years), adolescent/adult and current exposure to household SHS was assessed. Survey linear regression analyses were used to model the relationship of SHS exposure and echocardiographic measures of cardiac structure and function, adjusting for covariates (age, sex, study site, alcohol use, physical activity and education). Results SHS exposure in childhood only was associated with reduced E/A velocity ratio (β=-0.06 (SE 0.02), p=0.008). SHS exposure in adolescence/adult only was associated with increased left ventricular ejection fraction (LVEF) (1.2 (0.6), p=0.04), left atrial volume index (1.7 (0.8), p=0.04) and decreased isovolumic relaxation time (-0.003 (0.002), p=0.03). SHS exposure in childhood and adolescence/adult was associated with worse left ventricular global longitudinal strain (LVGLS) (two-chamber) (0.8 (0.4), p= 0.049). Compared with individuals who do not live with a tobacco smoker, individuals who currently live with at least one tobacco smoker had reduced LVEF (-1.4 (0.6), p=0.02), LVGLS (average) (0.9 (0.40), p=0.03), medial E′ velocity (-0.5 (0.2), p=0.01), E/A ratio (-0.09 (0.03), p=0.003) and right ventricular fractional area change (-0.02 (0.01), p=0.01) with increased isovolumic relaxation time (0.006 (0.003), p=0.04). Conclusions Past and current household exposure to SHS was associated with abnormalities in cardiac systolic and diastolic function. Reducing household SHS exposure may be an opportunity for cardiac dysfunction prevention to reduce the risk of future clinical heart failure.",
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T2 - Results from Echo-SOL

AU - Peña, Melissa Suzanne Burroughs

AU - Swett, Katrina

AU - Kaplan, Robert C.

AU - Perreira, Krista

AU - Daviglus, Martha

AU - Kansal, Mayank M.

AU - Cai, Jianwen

AU - Giachello, Aida L.

AU - Gellman, Marc D.

AU - Velazquez, Eric J.

AU - Rodriguez, Carlos J.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Objective To describe the relationship of household secondhand smoke (SHS) exposure and cardiac structure and function. Methods Participants (n=1069; 68 % female; age 45-74 years) without history of tobacco use, coronary artery disease or severe valvular disease were included. Past childhood (starting at age <13 years), adolescent/adult and current exposure to household SHS was assessed. Survey linear regression analyses were used to model the relationship of SHS exposure and echocardiographic measures of cardiac structure and function, adjusting for covariates (age, sex, study site, alcohol use, physical activity and education). Results SHS exposure in childhood only was associated with reduced E/A velocity ratio (β=-0.06 (SE 0.02), p=0.008). SHS exposure in adolescence/adult only was associated with increased left ventricular ejection fraction (LVEF) (1.2 (0.6), p=0.04), left atrial volume index (1.7 (0.8), p=0.04) and decreased isovolumic relaxation time (-0.003 (0.002), p=0.03). SHS exposure in childhood and adolescence/adult was associated with worse left ventricular global longitudinal strain (LVGLS) (two-chamber) (0.8 (0.4), p= 0.049). Compared with individuals who do not live with a tobacco smoker, individuals who currently live with at least one tobacco smoker had reduced LVEF (-1.4 (0.6), p=0.02), LVGLS (average) (0.9 (0.40), p=0.03), medial E′ velocity (-0.5 (0.2), p=0.01), E/A ratio (-0.09 (0.03), p=0.003) and right ventricular fractional area change (-0.02 (0.01), p=0.01) with increased isovolumic relaxation time (0.006 (0.003), p=0.04). Conclusions Past and current household exposure to SHS was associated with abnormalities in cardiac systolic and diastolic function. Reducing household SHS exposure may be an opportunity for cardiac dysfunction prevention to reduce the risk of future clinical heart failure.

AB - Objective To describe the relationship of household secondhand smoke (SHS) exposure and cardiac structure and function. Methods Participants (n=1069; 68 % female; age 45-74 years) without history of tobacco use, coronary artery disease or severe valvular disease were included. Past childhood (starting at age <13 years), adolescent/adult and current exposure to household SHS was assessed. Survey linear regression analyses were used to model the relationship of SHS exposure and echocardiographic measures of cardiac structure and function, adjusting for covariates (age, sex, study site, alcohol use, physical activity and education). Results SHS exposure in childhood only was associated with reduced E/A velocity ratio (β=-0.06 (SE 0.02), p=0.008). SHS exposure in adolescence/adult only was associated with increased left ventricular ejection fraction (LVEF) (1.2 (0.6), p=0.04), left atrial volume index (1.7 (0.8), p=0.04) and decreased isovolumic relaxation time (-0.003 (0.002), p=0.03). SHS exposure in childhood and adolescence/adult was associated with worse left ventricular global longitudinal strain (LVGLS) (two-chamber) (0.8 (0.4), p= 0.049). Compared with individuals who do not live with a tobacco smoker, individuals who currently live with at least one tobacco smoker had reduced LVEF (-1.4 (0.6), p=0.02), LVGLS (average) (0.9 (0.40), p=0.03), medial E′ velocity (-0.5 (0.2), p=0.01), E/A ratio (-0.09 (0.03), p=0.003) and right ventricular fractional area change (-0.02 (0.01), p=0.01) with increased isovolumic relaxation time (0.006 (0.003), p=0.04). Conclusions Past and current household exposure to SHS was associated with abnormalities in cardiac systolic and diastolic function. Reducing household SHS exposure may be an opportunity for cardiac dysfunction prevention to reduce the risk of future clinical heart failure.

KW - echocardiography

KW - epidemiology

KW - heart failure

KW - tobacco smoke pollution

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