TY - JOUR
T1 - Childhood and Adolescent Adversity and Cardiometabolic Outcomes
T2 - A Scientific Statement from the American Heart Association
AU - On behalf of the American Heart Association Council on Epidemiology and Prevention; Council on Cardiovascular Disease in the Young; Council on Functional Genomics and Translational Biology; Council on Cardiovascular and Stroke Nursing; and Council on Qual
AU - Suglia, Shakira F.
AU - Koenen, Karestan C.
AU - Boynton-Jarrett, Renée
AU - Chan, Paul S.
AU - Clark, Cari J.
AU - Danese, Andrea
AU - Faith, Myles S.
AU - Goldstein, Benjamin I.
AU - Hayman, Laura L.
AU - Isasi, Carmen R.
AU - Pratt, Charlotte A.
AU - Slopen, Natalie
AU - Sumner, Jennifer A.
AU - Turer, Aslan
AU - Turer, Christy B.
AU - Zachariah, Justin P.
N1 - Publisher Copyright:
© 2017 American Heart Association, Inc.
PY - 2018/1/30
Y1 - 2018/1/30
N2 - Adverse experiences in childhood and adolescence, defined as subjectively perceived threats to the safety or security of the child's bodily integrity, family, or social structures, are known to be associated with cardiometabolic outcomes over the life course into adulthood. This American Heart Association scientific statement reviews the scientific literature on the influence of childhood adversity on cardiometabolic outcomes that constitute the greatest public health burden in the United States, including obesity, hypertension, type 2 diabetes mellitus, and cardiovascular disease. This statement also conceptually outlines pathways linking adversity to cardiometabolic health, identifies evidence gaps, and provides suggestions for future research to inform practice and policy. We note that, despite a lack of objective agreement on what subjectively qualifies as exposure to childhood adversity and a dearth of prospective studies, substantial evidence documents an association between childhood adversity and cardiometabolic outcomes across the life course. Future studies that focus on mechanisms, resiliency, and vulnerability factors would further strengthen the evidence and provide much-needed information on targets for effective interventions. Given that childhood adversities affect cardiometabolic health and multiple health domains across the life course, interventions that ameliorate these initial upstream exposures may be more appropriate than interventions remediating downstream cardiovascular disease risk factor effects later in life.
AB - Adverse experiences in childhood and adolescence, defined as subjectively perceived threats to the safety or security of the child's bodily integrity, family, or social structures, are known to be associated with cardiometabolic outcomes over the life course into adulthood. This American Heart Association scientific statement reviews the scientific literature on the influence of childhood adversity on cardiometabolic outcomes that constitute the greatest public health burden in the United States, including obesity, hypertension, type 2 diabetes mellitus, and cardiovascular disease. This statement also conceptually outlines pathways linking adversity to cardiometabolic health, identifies evidence gaps, and provides suggestions for future research to inform practice and policy. We note that, despite a lack of objective agreement on what subjectively qualifies as exposure to childhood adversity and a dearth of prospective studies, substantial evidence documents an association between childhood adversity and cardiometabolic outcomes across the life course. Future studies that focus on mechanisms, resiliency, and vulnerability factors would further strengthen the evidence and provide much-needed information on targets for effective interventions. Given that childhood adversities affect cardiometabolic health and multiple health domains across the life course, interventions that ameliorate these initial upstream exposures may be more appropriate than interventions remediating downstream cardiovascular disease risk factor effects later in life.
KW - AHA Scientific Statements
KW - adolescent
KW - cardiovascular diseases
KW - child
KW - diabetes mellitus
KW - hypertension
KW - obesity
KW - stress
KW - trauma
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U2 - 10.1161/CIR.0000000000000536
DO - 10.1161/CIR.0000000000000536
M3 - Article
C2 - 29254928
AN - SCOPUS:85046716187
SN - 0009-7322
VL - 137
SP - e15-e28
JO - Circulation
JF - Circulation
IS - 5
ER -