Chickpea Intoxication

L. G. Costa, Michael Aschner

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Consumption of chickpeas, the seeds of Lathyrus sativus, can lead to the development of a neurological disease known as lathyrism, characterized by spastic weakness of the legs. The disease, known for more than 2000 years and once diffused worldwide, is now restricted to certain areas of Asia and Africa. Though its exact mechanism is still obscure, a prevailing hypothesis is that it may be due to the presence of large amounts of an excitatory amino acid (. β-. N-oxalylamino-. l-alanine) in chickpeas, which is toxic to nerve cells and produces some of the symptoms seen in lathyrism when administered to animals.

Original languageEnglish (US)
Title of host publicationEncyclopedia of the Neurological Sciences
PublisherElsevier Inc.
Number of pages1
ISBN (Electronic)9780123851574
ISBN (Print)9780123851581
DOIs
StatePublished - Jan 1 2014

Fingerprint

Lathyrism
Cicer
Lathyrus
Excitatory Amino Acids
Muscle Spasticity
Poisons
Alanine
Leg
Seeds
Neurons

Keywords

  • Chickpea
  • Grass pea
  • Lathyrism
  • Lathyrus sativus
  • Neuronal death
  • Nitriles
  • Spasticity
  • β-N-oxalylamino-l-alanine (BOAA)

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Costa, L. G., & Aschner, M. (2014). Chickpea Intoxication. In Encyclopedia of the Neurological Sciences Elsevier Inc.. https://doi.org/10.1016/B978-0-12-385157-4.00255-4

Chickpea Intoxication. / Costa, L. G.; Aschner, Michael.

Encyclopedia of the Neurological Sciences. Elsevier Inc., 2014.

Research output: Chapter in Book/Report/Conference proceedingChapter

Costa, LG & Aschner, M 2014, Chickpea Intoxication. in Encyclopedia of the Neurological Sciences. Elsevier Inc. https://doi.org/10.1016/B978-0-12-385157-4.00255-4
Costa LG, Aschner M. Chickpea Intoxication. In Encyclopedia of the Neurological Sciences. Elsevier Inc. 2014 https://doi.org/10.1016/B978-0-12-385157-4.00255-4
Costa, L. G. ; Aschner, Michael. / Chickpea Intoxication. Encyclopedia of the Neurological Sciences. Elsevier Inc., 2014.
@inbook{70e9969697b04b06970b87efbcf8fca7,
title = "Chickpea Intoxication",
abstract = "Consumption of chickpeas, the seeds of Lathyrus sativus, can lead to the development of a neurological disease known as lathyrism, characterized by spastic weakness of the legs. The disease, known for more than 2000 years and once diffused worldwide, is now restricted to certain areas of Asia and Africa. Though its exact mechanism is still obscure, a prevailing hypothesis is that it may be due to the presence of large amounts of an excitatory amino acid (. β-. N-oxalylamino-. l-alanine) in chickpeas, which is toxic to nerve cells and produces some of the symptoms seen in lathyrism when administered to animals.",
keywords = "Chickpea, Grass pea, Lathyrism, Lathyrus sativus, Neuronal death, Nitriles, Spasticity, β-N-oxalylamino-l-alanine (BOAA)",
author = "Costa, {L. G.} and Michael Aschner",
year = "2014",
month = "1",
day = "1",
doi = "10.1016/B978-0-12-385157-4.00255-4",
language = "English (US)",
isbn = "9780123851581",
booktitle = "Encyclopedia of the Neurological Sciences",
publisher = "Elsevier Inc.",
address = "United States",

}

TY - CHAP

T1 - Chickpea Intoxication

AU - Costa, L. G.

AU - Aschner, Michael

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Consumption of chickpeas, the seeds of Lathyrus sativus, can lead to the development of a neurological disease known as lathyrism, characterized by spastic weakness of the legs. The disease, known for more than 2000 years and once diffused worldwide, is now restricted to certain areas of Asia and Africa. Though its exact mechanism is still obscure, a prevailing hypothesis is that it may be due to the presence of large amounts of an excitatory amino acid (. β-. N-oxalylamino-. l-alanine) in chickpeas, which is toxic to nerve cells and produces some of the symptoms seen in lathyrism when administered to animals.

AB - Consumption of chickpeas, the seeds of Lathyrus sativus, can lead to the development of a neurological disease known as lathyrism, characterized by spastic weakness of the legs. The disease, known for more than 2000 years and once diffused worldwide, is now restricted to certain areas of Asia and Africa. Though its exact mechanism is still obscure, a prevailing hypothesis is that it may be due to the presence of large amounts of an excitatory amino acid (. β-. N-oxalylamino-. l-alanine) in chickpeas, which is toxic to nerve cells and produces some of the symptoms seen in lathyrism when administered to animals.

KW - Chickpea

KW - Grass pea

KW - Lathyrism

KW - Lathyrus sativus

KW - Neuronal death

KW - Nitriles

KW - Spasticity

KW - β-N-oxalylamino-l-alanine (BOAA)

UR - http://www.scopus.com/inward/record.url?scp=85043259127&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85043259127&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-385157-4.00255-4

DO - 10.1016/B978-0-12-385157-4.00255-4

M3 - Chapter

AN - SCOPUS:85043259127

SN - 9780123851581

BT - Encyclopedia of the Neurological Sciences

PB - Elsevier Inc.

ER -