Chemotherapy versus chemotherapy plus radiotherapy in the treatment of tonsillar squamous cell carcinoma in the dog.

M. B. Brooks, R. E. Matus, C. E. Leifer, A. A. Alfieri, A. K. Patnaik

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The effect of adjuvant chemotherapy and combined chemotherapy and radiotherapy in 22 dogs with advanced canine tonsillar carcinoma (World Health Organization [WHO], T2-3 primary tumor with infiltration into surrounding tissues) was evaluated. There were four treatment groups of at least five dogs each. Combinations of chemotherapeutic drugs reported to have activity against squamous cell carcinoma in humans and dogs (doxorubicin, cisplatin, vinblastine, and cyclophosphamide) were administered after tonsillectomy. Radiation therapy (orthovoltage type, external beam) was combined with chemotherapy in one treatment group. The dogs that had combination radiation therapy and chemotherapy had higher response rates and significantly longer survival times. However, most dogs died of progression of disease.

Original languageEnglish (US)
Pages (from-to)206-211
Number of pages6
JournalJournal of veterinary internal medicine / American College of Veterinary Internal Medicine
Volume2
Issue number4
StatePublished - Oct 1988
Externally publishedYes

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squamous cell carcinoma
radiotherapy
drug therapy
Squamous Cell Carcinoma
Radiotherapy
Dogs
Drug Therapy
dogs
Therapeutics
Tonsillectomy
Vinblastine
vinblastine
Drug Combinations
Adjuvant Chemotherapy
combination drug therapy
cisplatin
doxorubicin
cyclophosphamide
Doxorubicin
Cyclophosphamide

ASJC Scopus subject areas

  • veterinary(all)

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Chemotherapy versus chemotherapy plus radiotherapy in the treatment of tonsillar squamous cell carcinoma in the dog. / Brooks, M. B.; Matus, R. E.; Leifer, C. E.; Alfieri, A. A.; Patnaik, A. K.

In: Journal of veterinary internal medicine / American College of Veterinary Internal Medicine, Vol. 2, No. 4, 10.1988, p. 206-211.

Research output: Contribution to journalArticle

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