Chemotherapy Versus Chemotherapy Plus Radiotherapy in the Treatment of Tonsillar Squamous Cell Carcinoma in the Dog

Marjory B. Brooks, Robert E. Matus, Connie E. Leifer, Alan A. Alfieri, Amiya K. Patnaik

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

The effect of adjuvant chemotherapy and combined chemotherapy and radiotherapy in 22 dogs with advanced canine tonsillar carcinoma (World Health Organization [WHO], T2‐3 primary tumor with infiltration into surrounding tissues) was evaluated. There were four treatment groups of at least five dogs each. Combinations of chemotherapeutic drugs reported to have activity against squamous cell carcinoma in humans and dogs (doxorubicin, cisplatin, vinblastine, and cyclophosphamide) were administered after tonsillectomy. Radiation therapy (orthovoltage type, external beam) was combined with chemotherapy in one treatment group. The dogs that had combination radiation therapy and chemotherapy had higher response rates and significantly longer survival times. However, most dogs died of progression of disease. (Journal of Veterinary Internal Medicine 1988; 2:206–211)

Original languageEnglish (US)
Pages (from-to)206-211
Number of pages6
JournalJournal of Veterinary Internal Medicine
Volume2
Issue number4
DOIs
StatePublished - Oct 1988

ASJC Scopus subject areas

  • veterinary(all)

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