Chemotherapy Versus Chemotherapy Plus Radiotherapy in the Treatment of Tonsillar Squamous Cell Carcinoma in the Dog

Marjory B. Brooks, Robert E. Matus, Connie E. Leifer, Alan A. Alfieri, Amiya K. Patnaik

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34 Scopus citations


The effect of adjuvant chemotherapy and combined chemotherapy and radiotherapy in 22 dogs with advanced canine tonsillar carcinoma (World Health Organization [WHO], T2‐3 primary tumor with infiltration into surrounding tissues) was evaluated. There were four treatment groups of at least five dogs each. Combinations of chemotherapeutic drugs reported to have activity against squamous cell carcinoma in humans and dogs (doxorubicin, cisplatin, vinblastine, and cyclophosphamide) were administered after tonsillectomy. Radiation therapy (orthovoltage type, external beam) was combined with chemotherapy in one treatment group. The dogs that had combination radiation therapy and chemotherapy had higher response rates and significantly longer survival times. However, most dogs died of progression of disease. (Journal of Veterinary Internal Medicine 1988; 2:206–211)

Original languageEnglish (US)
Pages (from-to)206-211
Number of pages6
JournalJournal of Veterinary Internal Medicine
Issue number4
Publication statusPublished - Oct 1988


ASJC Scopus subject areas

  • veterinary(all)

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