Chemotherapy Versus Chemotherapy Plus Radiotherapy in the Treatment of Tonsillar Squamous Cell Carcinoma in the Dog

Marjory B. Brooks; Robert E. Matus; Connie E. Leifer; Alan A. Alfieri; Amiya K. Patnaik

doi:10.1111/j.1939-1676.1988.tb00318.x

Chemotherapy Versus Chemotherapy Plus Radiotherapy in the Treatment of Tonsillar Squamous Cell Carcinoma in the Dog

Marjory B. Brooks, Robert E. Matus, Connie E. Leifer, Alan A. Alfieri, Amiya K. Patnaik

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46 Scopus citations

Abstract

The effect of adjuvant chemotherapy and combined chemotherapy and radiotherapy in 22 dogs with advanced canine tonsillar carcinoma (World Health Organization [WHO], T2‐3 primary tumor with infiltration into surrounding tissues) was evaluated. There were four treatment groups of at least five dogs each. Combinations of chemotherapeutic drugs reported to have activity against squamous cell carcinoma in humans and dogs (doxorubicin, cisplatin, vinblastine, and cyclophosphamide) were administered after tonsillectomy. Radiation therapy (orthovoltage type, external beam) was combined with chemotherapy in one treatment group. The dogs that had combination radiation therapy and chemotherapy had higher response rates and significantly longer survival times. However, most dogs died of progression of disease. (Journal of Veterinary Internal Medicine 1988; 2:206–211)

Original language	English (US)
Pages (from-to)	206-211
Number of pages	6
Journal	Journal of Veterinary Internal Medicine
Volume	2
Issue number	4
DOIs	https://doi.org/10.1111/j.1939-1676.1988.tb00318.x
State	Published - Oct 1988
Externally published	Yes

ASJC Scopus subject areas

General Veterinary

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10.1111/j.1939-1676.1988.tb00318.x

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title = "Chemotherapy Versus Chemotherapy Plus Radiotherapy in the Treatment of Tonsillar Squamous Cell Carcinoma in the Dog",

abstract = "The effect of adjuvant chemotherapy and combined chemotherapy and radiotherapy in 22 dogs with advanced canine tonsillar carcinoma (World Health Organization [WHO], T2‐3 primary tumor with infiltration into surrounding tissues) was evaluated. There were four treatment groups of at least five dogs each. Combinations of chemotherapeutic drugs reported to have activity against squamous cell carcinoma in humans and dogs (doxorubicin, cisplatin, vinblastine, and cyclophosphamide) were administered after tonsillectomy. Radiation therapy (orthovoltage type, external beam) was combined with chemotherapy in one treatment group. The dogs that had combination radiation therapy and chemotherapy had higher response rates and significantly longer survival times. However, most dogs died of progression of disease. (Journal of Veterinary Internal Medicine 1988; 2:206–211)",

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AU - Alfieri, Alan A.

AU - Patnaik, Amiya K.

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Chemotherapy Versus Chemotherapy Plus Radiotherapy in the Treatment of Tonsillar Squamous Cell Carcinoma in the Dog

Abstract

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