@article{e3872795dd314a40a56647b766682f24,
title = "Chemotherapy regimens and treatment protocols for laryngeal cancer",
abstract = "Importance of the field: Laryngeal cancer has been the model of curative-intent organ-preserving therapies in clinical oncology. Although the optimal care of patients with laryngeal cancer is truly multidisciplinary, with progressive advances in surgical, radiation, and medical oncology, the development of effective systemic therapies has been a major component of the therapeutic arsenal against laryngeal cancer. Areas covered in this review: This review will discuss the rapidly evolving roles of chemotherapy in the management of locally advanced and metastatic laryngeal cancer. What the reader will gain: The reader will gain a historical perspective on this evolution in treatment and will appreciate current treatment challenges and promising future directions in optimizing therapeutic efficacy in functional larynx preservation and in patient survival. Take home message: The treatment of most patients with laryngeal cancer with systemic therapy represents an opportunity to positively impact functional outcomes with an anatomically and functionally preserved larynx. Future challenges include identification of novel therapies and optimizing therapy protocols for individualized patient care.",
keywords = "Cancer, Chemoradiotherapy, Chemotherapy, Laryngeal cancer, Larynx, Molecular targeted therapy, Treatment",
author = "Missak Haigentz and Silver, {Carl E.} and Hartl, {Dana M.} and Takes, {Robert P.} and Rodrigo, {Juan P.} and Robbins, {K. Thomas} and Alessandra Rinaldo and Alfio Ferlito",
note = "Funding Information: Therasse P, Arbuck SG, Eisenhauer EA, et al. New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst 2000;92:205-16 Tarpley JL, Chretien PB, Alexander JC Jr, et al. High dose methotrexate as a preoperative adjuvant in the treatment of epidermoid carcinoma of the head and neck. A feasibility study and clinical trial. Am J Surg 1975;130:481-6 Kun LE, Toohill RJ, Holoye PY, et al. A randomized study of adjuvant chemotherapy for cancer of the upper aerodigestive tract. Int J Radiat Oncol Biol Phys 1986;12:173-8 Adjuvant chemotherapy for advanced head and neck squamous carcinoma. Final report of the Head and Neck Contracts Program. Cancer 1987;60:301-11 Toohill RJ, Duncavage JA, Grossmam TW, et al. The effects of delay in standard treatment due to induction chemotherapy in two randomized prospective studies. Laryngoscope 1987;97:407-12 Schuller DE, Metch B, Stein DW, et al. Preoperative chemotherapy in advanced resectable head and neck cancer: final report of the Southwest Oncology Group. Laryngoscope 1988;98:1205-11",
year = "2010",
month = jun,
doi = "10.1517/14656561003749256",
language = "English (US)",
volume = "11",
pages = "1305--1316",
journal = "Expert Opinion on Pharmacotherapy",
issn = "1465-6566",
publisher = "Informa Healthcare",
number = "8",
}
