TY - JOUR
T1 - Chemotherapy-induced metastasis
T2 - Molecular mechanisms, clinical manifestations, therapeutic interventions
AU - Karagiannis, George S.
AU - Condeelis, John S.
AU - Oktay, Maja H.
N1 - Funding Information:
This work was supported by the National Cancer Institute (NCI) at the NIH (grant numbers CA216248 and CA100324), and by the Gruss Lipper Biophotonics Center and its Integrated Imaging Program at the Albert Einstein College of Medicine
Publisher Copyright:
© 2019 American Association for Cancer Research.
PY - 2019/9/15
Y1 - 2019/9/15
N2 - Chemotherapy offers long-term clinical benefits to many patients with advanced cancer. However, recent evidence has linked the cytotoxic effects of chemotherapy with the de novo elicitation of a prometastatic tumor microenvironment. This "modified" tumor microenvironment is triggered by a chemotherapy-driven cytokine storm or through direct effects of certain chemotherapeutics on stromal and/or immune cells, the most critical being tumor-associated macrophages. These chemotherapy-educated cells act as facilitators in tumor-host cell interactions promoting the establishment of distant metastasis. Certain clinical studies now offer substantial evidence that prometastatic changes are indeed identified in the tumor microenvironment of certain patient subpopulations, especially those that do not present with any pathologic response after neoadjuvant chemotherapy. Deciphering the exact contextual prerequisites for chemotherapy-driven metastasis will be paramount for designing novel mechanism-based treatments for circumventing chemotherapy-induced metastasis.
AB - Chemotherapy offers long-term clinical benefits to many patients with advanced cancer. However, recent evidence has linked the cytotoxic effects of chemotherapy with the de novo elicitation of a prometastatic tumor microenvironment. This "modified" tumor microenvironment is triggered by a chemotherapy-driven cytokine storm or through direct effects of certain chemotherapeutics on stromal and/or immune cells, the most critical being tumor-associated macrophages. These chemotherapy-educated cells act as facilitators in tumor-host cell interactions promoting the establishment of distant metastasis. Certain clinical studies now offer substantial evidence that prometastatic changes are indeed identified in the tumor microenvironment of certain patient subpopulations, especially those that do not present with any pathologic response after neoadjuvant chemotherapy. Deciphering the exact contextual prerequisites for chemotherapy-driven metastasis will be paramount for designing novel mechanism-based treatments for circumventing chemotherapy-induced metastasis.
UR - http://www.scopus.com/inward/record.url?scp=85072234819&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85072234819&partnerID=8YFLogxK
U2 - 10.1158/0008-5472.CAN-19-1147
DO - 10.1158/0008-5472.CAN-19-1147
M3 - Review article
C2 - 31431464
AN - SCOPUS:85072234819
VL - 79
SP - 4567
EP - 4577
JO - Cancer Research
JF - Cancer Research
SN - 0008-5472
IS - 18
ER -