Chemotaxis of metastatic tumor cells

Clues to mechanisms from the Dictyostelium paradigm

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Amoeboid movement, and in some cases, amoeboid chemotaxis, is a key step in tumor metastasis. The high degree of conservation in signal transduction pathways and motile machinery in eukaryotic cells suggests that insights and molecular probes developed from the study of these processes in easily manipulated experimental model systems will be applicable directly to experimentally intractable tumor cells. One such model system, Dictyostelium discoideum, is discussed in terms of the molecular events involved in amoeboid chemotaxis. The application of insights and assays developed with Dictyostelium to early events in the chemotaxis of Lewis lung carcinoma cells is reviewed.

Original languageEnglish (US)
Pages (from-to)55-68
Number of pages14
JournalCancer and Metastasis Review
Volume11
Issue number1
DOIs
StatePublished - Mar 1992

Fingerprint

Dictyostelium
Chemotaxis
Lewis Lung Carcinoma
Molecular Probes
Neoplasms
Eukaryotic Cells
Signal Transduction
Theoretical Models
Neoplasm Metastasis

Keywords

  • actin
  • actin binding proteins
  • cortical expansion model
  • signal transduction

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Chemotaxis of metastatic tumor cells : Clues to mechanisms from the Dictyostelium paradigm. / Condeelis, John S.; Jones, Joan; Segall, Jeffrey E.

In: Cancer and Metastasis Review, Vol. 11, No. 1, 03.1992, p. 55-68.

Research output: Contribution to journalArticle

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