Chemotaxis in cancer

Evanthia T. Roussos; John S. Condeelis; Antonia Patsialou

doi:10.1038/nrc3078

Chemotaxis in cancer

Evanthia T. Roussos, John S. Condeelis, Antonia Patsialou

Research output: Contribution to journal › Review article › peer-review

699 Scopus citations

Abstract

Chemotaxis of tumour cells and stromal cells in the surrounding microenvironment is an essential component of tumour dissemination during progression and metastasis. This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulate chemotaxis in tumour cells and how chemotaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread. The central importance of chemotaxis in cancer progression is highlighted by discussion of the use of chemotaxis as a prognostic marker, a treatment end point and a target of therapeutic intervention.

Original language	English (US)
Pages (from-to)	573-587
Number of pages	15
Journal	Nature Reviews Cancer
Volume	11
Issue number	8
DOIs	https://doi.org/10.1038/nrc3078
State	Published - Aug 2011
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/nrc3078

Cite this

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title = "Chemotaxis in cancer",

abstract = "Chemotaxis of tumour cells and stromal cells in the surrounding microenvironment is an essential component of tumour dissemination during progression and metastasis. This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulate chemotaxis in tumour cells and how chemotaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread. The central importance of chemotaxis in cancer progression is highlighted by discussion of the use of chemotaxis as a prognostic marker, a treatment end point and a target of therapeutic intervention.",

author = "Roussos, {Evanthia T.} and Condeelis, {John S.} and Antonia Patsialou",

note = "Funding Information: The authors would like to thank members of the Condeelis laboratory for helpful discussions. We thank especially J. Wyckoff and D. Entenberg, associates at the Gruss Lipper Biophotonics Center (GLBC) of the Albert Einstein College of Medicine, for their critical comments and suggestions for this manuscript and their help in figure preparation. The authors apologize to those whose work is not cited owing to space limitations. The authors{\textquoteright} research is funded by grants CA150344 (to E.T.R), CA100324 (to J.S.C.) and CA113395 (to A.P.) from the US National Institutes of Health.",

year = "2011",

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doi = "10.1038/nrc3078",

language = "English (US)",

volume = "11",

pages = "573--587",

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AU - Patsialou, Antonia

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N2 - Chemotaxis of tumour cells and stromal cells in the surrounding microenvironment is an essential component of tumour dissemination during progression and metastasis. This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulate chemotaxis in tumour cells and how chemotaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread. The central importance of chemotaxis in cancer progression is highlighted by discussion of the use of chemotaxis as a prognostic marker, a treatment end point and a target of therapeutic intervention.

AB - Chemotaxis of tumour cells and stromal cells in the surrounding microenvironment is an essential component of tumour dissemination during progression and metastasis. This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulate chemotaxis in tumour cells and how chemotaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread. The central importance of chemotaxis in cancer progression is highlighted by discussion of the use of chemotaxis as a prognostic marker, a treatment end point and a target of therapeutic intervention.

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Chemotaxis in cancer

Abstract

ASJC Scopus subject areas

UN SDGs

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