Chemosterilant action of anthramycin

A proposed mechanism

Susan Band Horwitz, Shen Chin Chang, Arthur P. Grollman, Alexej B. Bořkovec

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The activity of anthramycin and structurally related analogs as chemosterilants of the housefly, Musca domestica L., correlates closely with the action of these compounds as inhibitors of Escherichia coli RNA polymerase. Since inhibition of RNA polymerase by anthramycin reflects binding of this antibiotic to the DNA primer required for enzyme activity, we propose that the interaction of anthramycin with DNA may also account for its action as a chemosterilant.

Original languageEnglish (US)
Pages (from-to)159-161
Number of pages3
JournalScience
Volume174
Issue number4005
StatePublished - 1971

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Anthramycin
Chemosterilants
Houseflies
DNA-Directed RNA Polymerases
DNA Primers
Escherichia coli
Anti-Bacterial Agents
Enzymes

ASJC Scopus subject areas

  • General

Cite this

Band Horwitz, S., Chang, S. C., Grollman, A. P., & Bořkovec, A. B. (1971). Chemosterilant action of anthramycin: A proposed mechanism. Science, 174(4005), 159-161.

Chemosterilant action of anthramycin : A proposed mechanism. / Band Horwitz, Susan; Chang, Shen Chin; Grollman, Arthur P.; Bořkovec, Alexej B.

In: Science, Vol. 174, No. 4005, 1971, p. 159-161.

Research output: Contribution to journalArticle

Band Horwitz, S, Chang, SC, Grollman, AP & Bořkovec, AB 1971, 'Chemosterilant action of anthramycin: A proposed mechanism', Science, vol. 174, no. 4005, pp. 159-161.
Band Horwitz S, Chang SC, Grollman AP, Bořkovec AB. Chemosterilant action of anthramycin: A proposed mechanism. Science. 1971;174(4005):159-161.
Band Horwitz, Susan ; Chang, Shen Chin ; Grollman, Arthur P. ; Bořkovec, Alexej B. / Chemosterilant action of anthramycin : A proposed mechanism. In: Science. 1971 ; Vol. 174, No. 4005. pp. 159-161.
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