Chemosterilant action of anthramycin: A proposed mechanism

Susan B. Horwitz, Shen Chin Chang, Arthur P. Grollman, Alexej B. Bořkovec

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

The activity of anthramycin and structurally related analogs as chemosterilants of the housefly, Musca domestica L., correlates closely with the action of these compounds as inhibitors of Escherichia coli RNA polymerase. Since inhibition of RNA polymerase by anthramycin reflects binding of this antibiotic to the DNA primer required for enzyme activity, we propose that the interaction of anthramycin with DNA may also account for its action as a chemosterilant.

Original languageEnglish (US)
Pages (from-to)159-161
Number of pages3
JournalScience
Volume174
Issue number4005
DOIs
StatePublished - Jan 1 1971

ASJC Scopus subject areas

  • General

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    Horwitz, S. B., Chang, S. C., Grollman, A. P., & Bořkovec, A. B. (1971). Chemosterilant action of anthramycin: A proposed mechanism. Science, 174(4005), 159-161. https://doi.org/10.1126/science.174.4005.159