Chemokines in the ischemic myocardium: From inflammation to fibrosis

Research output: Contribution to journalArticle

134 Citations (Scopus)

Abstract

Myocardial infarction is associated with an inflammatory response leading to leukocyte recruitment, healing and formation of a scar. Members of the chemokine superfamily are rapidly induced in the infarcted myocardium and may critically regulate the post-infarction inflammatory response. CXCL8/Interleukin (IL)-8 is upregulated in the infarcted area and may induce neutrophil infiltration. In addition, mononuclear cell chemoattractants, such as the CC chemokines CCL2/Monocyte Chemoattractant Protein (MCP)-1, CCL3/Macrophage Inflammatory Protein (MIP)-1α, and CCL4/MIP-1β are expressed in the ischemic area, and may regulate monocyte and lymphocyte recruitment. However, chemokines may have additional effects on healing infarcts beyond their leukotactic properties. The CXC chemokine CXCL10/Interferon-γ inducible Protein (IP)-10, a potent angiostatic factor with antifibrotic properties, is induced in the infarct and may prevent premature angiogenesis and fibrous tissue deposition, until the infarct is debrided and provisional matrix necessary to support granulation tissue ingrowth is formed. Chemokine induction in the infarct is transient, suggesting that inhibitory mediators (such as transforming growth Factor (TGF)-β) may be activated suppressing chemokine synthesis and leading to resolution of inflammation and transition to fibrosis. Brief repetitive ischemia in mice also results in chemokine upregulation followed by suppression of chemokine synthesis and interstitial fibrosis, in the absence of myocardial infarction. Chemokine expression may play a role in the pathogenesis of non-infarctive ischemic cardiomyopathy, where early ischemia-induced chemokine expression may be followed by activation of inhibitory mediators that suppress inflammation, but induce fibrosis.

Original languageEnglish (US)
Pages (from-to)585-595
Number of pages11
JournalInflammation Research
Volume53
Issue number11
DOIs
StatePublished - Nov 2004
Externally publishedYes

Fingerprint

Chemokines
Myocardium
Fibrosis
Inflammation
Chemokine CXCL10
Macrophage Inflammatory Proteins
Chemokine CCL2
Ischemia
Myocardial Infarction
Tissue
CXC Chemokines
Inflammation Mediators
CC Chemokines
Granulation
Lymphocytes
Granulation Tissue
Neutrophil Infiltration
Chemotactic Factors
Transforming Growth Factors
Interleukin-8

Keywords

  • Chemokines
  • Endothelium
  • Inflammation
  • Leukocyte
  • Myocardial ischemia

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)
  • Immunology
  • Cell Biology

Cite this

Chemokines in the ischemic myocardium : From inflammation to fibrosis. / Frangogiannis, Nikolaos G.

In: Inflammation Research, Vol. 53, No. 11, 11.2004, p. 585-595.

Research output: Contribution to journalArticle

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