Chemokines and tuberculosis

Holly M.Scott Algood, John Chan, Jo Anne L. Flynn

Research output: Contribution to journalReview article

166 Scopus citations

Abstract

Mycobacterium tuberculosis is a respiratory pathogen responsible for tuberculosis. A primary pathologic feature of M. tuberculosis infection is the formation of a granuloma. Immune cells migrate to the lung and then through the lung to the site of infection to form a granuloma. This structure contains the infection, and is often maintained for a long period of time. The signals responsible for granuloma formation and maintenance are largely unknown. Since chemokines and chemokine receptors direct cells to specific sites within the tissues, it is plausible that these cells participate in granuloma formation. In this review, the current literature on chemokines and M. tuberculosis infection, as well as the specific role that tumor necrosis factor alpha (TNF-α) plays in granuloma formation and chemokine expression are discussed.

Original languageEnglish (US)
Pages (from-to)467-477
Number of pages11
JournalCytokine and Growth Factor Reviews
Volume14
Issue number6
DOIs
StatePublished - Dec 2003

Keywords

  • Chemokine
  • Granuloma
  • Lung
  • Tuberculosis
  • Tumor necrosis factor alpha

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

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