Chemokine-dependent mechanisms of leukocyte trafficking across a model of the blood-brain barrier

E. A. Eugenin, Joan W. Berman

Research output: Contribution to journalArticle

101 Scopus citations

Abstract

Leukocyte transmigration across the blood-brain barrier (BBB) is a multistep process that can be mediated by chemokines. These low-molecular-weight chemoattractant proteins are secreted by cells within the central nervous system (CNS) in response to injury or on activation. Leukocytes transmigrate toward this chemokine gradient, crossing the BBB and gaining access to the CNS parenchyma. Depending on the chemokine, the nature of the insult, and the type of cell that transmigrates, the BBB integrity may be disrupted, leading to its increased permeability. Both the inflammation resulting from leukocyte transmigration and BBB perturbations contribute to CNS pathology. The mechanisms that mediate leukocyte transmigration and BBB disruption, as well as tissue culture models that are used to study leukocyte trafficking, are the focus of this review.

Original languageEnglish (US)
Pages (from-to)351-361
Number of pages11
JournalMethods
Volume29
Issue number4
DOIs
StatePublished - Apr 1 2003

Keywords

  • Astrocyte
  • BBB
  • Chemotaxis
  • Endothelial
  • Leukocyte
  • PBMC
  • Transmigration
  • Transwell

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Chemokine-dependent mechanisms of leukocyte trafficking across a model of the blood-brain barrier'. Together they form a unique fingerprint.

  • Cite this