Chemokine and chemokine-receptor expression in human glial elements: Induction by the HIV protein, Tat, and chemokine autoregulation

Carrie M. McManus, Karen Weidenheim, Scott E. Woodman, Jeranil Nunez, Joseph Hesselgesser, Avindra Nath, Joan W. Berman

Research output: Contribution to journalArticlepeer-review

150 Scopus citations

Abstract

Human immunodeficiency virus (HIV) encephalitis is a prominent pathology seen in children infected with HIV. Immunohistochemical analyses of pediatric brain tissue showed distinct differences in expression of C-C chemokines and their receptors between children with HIV encephalitis and those with non-CNS-related pathologies. Evidence suggests that soluble factors such as HIV Tat released from HIV-infected cells may have pathogenic effects. Our results show Tat effects on chemokines and their receptors in microglia and astrocytes as well as chemokine autoregulation in these cells. These results provide evidence for the complex interplay of Tat, chemokines, and chemokine receptors in the inflammatory processes of HIV encephalitis and illustrate an important new role for chemokines as autocrine regulators.

Original languageEnglish (US)
Pages (from-to)1441-1453
Number of pages13
JournalAmerican Journal of Pathology
Volume156
Issue number4
DOIs
StatePublished - 2000

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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