Chemokine and chemokine-receptor expression in human glial elements

Induction by the HIV protein, Tat, and chemokine autoregulation

C. M. McManus, Karen M. Weidenheim, S. E. Woodman, J. Nunez, J. Hesselgesser, A. Nath, Joan W. Berman

Research output: Contribution to journalArticle

147 Citations (Scopus)

Abstract

Human immunodeficiency virus (HIV) encephalitis is a prominent pathology seen in children infected with HIV. Immunohistochemical analyses of pediatric brain tissue showed distinct differences in expression of C-C chemokines and their receptors between children with HIV encephalitis and those with non-CNS-related pathologies. Evidence suggests that soluble factors such as HIV Tat released from HIV-infected cells may have pathogenic effects. Our results show Tat effects on chemokines and their receptors in microglia and astrocytes as well as chemokine autoregulation in these cells. These results provide evidence for the complex interplay of Tat, chemokines, and chemokine receptors in the inflammatory processes of HIV encephalitis and illustrate an important new role for chemokines as autocrine regulators.

Original languageEnglish (US)
Pages (from-to)1441-1453
Number of pages13
JournalAmerican Journal of Pathology
Volume156
Issue number4
StatePublished - 2000

Fingerprint

Human Immunodeficiency Virus Proteins
Chemokine Receptors
Chemokines
Neuroglia
Homeostasis
HIV
Encephalitis
Pathology
CC Chemokines
Microglia
Astrocytes
Pediatrics
Brain

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Chemokine and chemokine-receptor expression in human glial elements : Induction by the HIV protein, Tat, and chemokine autoregulation. / McManus, C. M.; Weidenheim, Karen M.; Woodman, S. E.; Nunez, J.; Hesselgesser, J.; Nath, A.; Berman, Joan W.

In: American Journal of Pathology, Vol. 156, No. 4, 2000, p. 1441-1453.

Research output: Contribution to journalArticle

@article{893e85a20e72474a8f52f1b31312caa8,
title = "Chemokine and chemokine-receptor expression in human glial elements: Induction by the HIV protein, Tat, and chemokine autoregulation",
abstract = "Human immunodeficiency virus (HIV) encephalitis is a prominent pathology seen in children infected with HIV. Immunohistochemical analyses of pediatric brain tissue showed distinct differences in expression of C-C chemokines and their receptors between children with HIV encephalitis and those with non-CNS-related pathologies. Evidence suggests that soluble factors such as HIV Tat released from HIV-infected cells may have pathogenic effects. Our results show Tat effects on chemokines and their receptors in microglia and astrocytes as well as chemokine autoregulation in these cells. These results provide evidence for the complex interplay of Tat, chemokines, and chemokine receptors in the inflammatory processes of HIV encephalitis and illustrate an important new role for chemokines as autocrine regulators.",
author = "McManus, {C. M.} and Weidenheim, {Karen M.} and Woodman, {S. E.} and J. Nunez and J. Hesselgesser and A. Nath and Berman, {Joan W.}",
year = "2000",
language = "English (US)",
volume = "156",
pages = "1441--1453",
journal = "American Journal of Pathology",
issn = "0002-9440",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Chemokine and chemokine-receptor expression in human glial elements

T2 - Induction by the HIV protein, Tat, and chemokine autoregulation

AU - McManus, C. M.

AU - Weidenheim, Karen M.

AU - Woodman, S. E.

AU - Nunez, J.

AU - Hesselgesser, J.

AU - Nath, A.

AU - Berman, Joan W.

PY - 2000

Y1 - 2000

N2 - Human immunodeficiency virus (HIV) encephalitis is a prominent pathology seen in children infected with HIV. Immunohistochemical analyses of pediatric brain tissue showed distinct differences in expression of C-C chemokines and their receptors between children with HIV encephalitis and those with non-CNS-related pathologies. Evidence suggests that soluble factors such as HIV Tat released from HIV-infected cells may have pathogenic effects. Our results show Tat effects on chemokines and their receptors in microglia and astrocytes as well as chemokine autoregulation in these cells. These results provide evidence for the complex interplay of Tat, chemokines, and chemokine receptors in the inflammatory processes of HIV encephalitis and illustrate an important new role for chemokines as autocrine regulators.

AB - Human immunodeficiency virus (HIV) encephalitis is a prominent pathology seen in children infected with HIV. Immunohistochemical analyses of pediatric brain tissue showed distinct differences in expression of C-C chemokines and their receptors between children with HIV encephalitis and those with non-CNS-related pathologies. Evidence suggests that soluble factors such as HIV Tat released from HIV-infected cells may have pathogenic effects. Our results show Tat effects on chemokines and their receptors in microglia and astrocytes as well as chemokine autoregulation in these cells. These results provide evidence for the complex interplay of Tat, chemokines, and chemokine receptors in the inflammatory processes of HIV encephalitis and illustrate an important new role for chemokines as autocrine regulators.

UR - http://www.scopus.com/inward/record.url?scp=0033843359&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033843359&partnerID=8YFLogxK

M3 - Article

VL - 156

SP - 1441

EP - 1453

JO - American Journal of Pathology

JF - American Journal of Pathology

SN - 0002-9440

IS - 4

ER -