Substrates containing isotope labels at specific atoms are required for transition-state analysis based on the measurement of multiple kinetic isotope effects.36S-labeled L-methionine and S-adenosyl-L-methionine were synthesized from elemental sulfur using a chemoenzymatic approach with >98% 36S enrichment. This method provides access to previously inaccessible sulfur isotope-labeled substrates for sulfur kinetic isotope effect studies. (Chemical Equation Presented).
ASJC Scopus subject areas
- Organic Chemistry