Abstract
Substrates containing isotope labels at specific atoms are required for transition-state analysis based on the measurement of multiple kinetic isotope effects.36S-labeled L-methionine and S-adenosyl-L-methionine were synthesized from elemental sulfur using a chemoenzymatic approach with >98% 36S enrichment. This method provides access to previously inaccessible sulfur isotope-labeled substrates for sulfur kinetic isotope effect studies. (Chemical Equation Presented).
Original language | English (US) |
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Pages (from-to) | 5344-5347 |
Number of pages | 4 |
Journal | Journal of Organic Chemistry |
Volume | 80 |
Issue number | 10 |
DOIs | |
State | Published - May 15 2015 |
ASJC Scopus subject areas
- Organic Chemistry