Chemical Speciation of Selenium and Mercury as Determinant of Their Neurotoxicity

C. S. Oliveira, B. C. Piccoli, Michael Aschner, J. B.T. Rocha

Research output: Chapter in Book/Report/Conference proceedingChapter

23 Scopus citations

Abstract

The antagonism of mercury toxicity by selenium has been well documented. Mercury is a toxic metal, widespread in the environment. The main target organs (kidneys, lungs, or brain) of mercury vary depending on its chemical forms (inorganic or organic). Selenium is a semimetal essential to mammalian life as part of the amino acid selenocysteine, which is required to the synthesis of the selenoproteins. This chapter has the aim of disclosing the role of selenide or hydrogen selenide (Se−2 or HSe) as central metabolite of selenium and as an important antidote of the electrophilic mercury forms (particularly, Hg2+ and MeHg). Emphasis will be centered on the neurotoxicity of electrophile forms of mercury and selenium. The controversial participation of electrophile mercury and selenium forms in the development of some neurodegenerative disease will be briefly presented. The potential pharmacological use of organoseleno compounds (Ebselen and diphenyl diselenide) in the treatment of mercury poisoning will be considered. The central role of thiol (−SH) and selenol (−SeH) groups as the generic targets of electrophile mercury forms and the need of new in silico tools to guide the future biological researches will be commented.

Original languageEnglish (US)
Title of host publicationAdvances in Neurobiology
PublisherSpringer New York LLC
Pages53-83
Number of pages31
Volume18
DOIs
StatePublished - 2017

Publication series

NameAdvances in Neurobiology
Volume18
ISSN (Print)2190-5215

Keywords

  • Cysteine
  • Neurotoxicity
  • Selenide
  • Selenocysteine
  • Selenoproteins

ASJC Scopus subject areas

  • Biochemistry
  • Neurology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience

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  • Cite this

    Oliveira, C. S., Piccoli, B. C., Aschner, M., & Rocha, J. B. T. (2017). Chemical Speciation of Selenium and Mercury as Determinant of Their Neurotoxicity. In Advances in Neurobiology (Vol. 18, pp. 53-83). (Advances in Neurobiology; Vol. 18). Springer New York LLC. https://doi.org/10.1007/978-3-319-60189-2_4