Chelate mediated transfer of iron from transferrin to desferrioxamine

Simeon Pollack, P. Aisen, F. D. Lasky, G. Vanderhoff

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Desferrioxamine, widely used for the treatment of iron overload in Cooley's anaemia, binds iron so tightly that it should quantitatively remove iron from transferrin. Studies conducted in vivo and in vitro, however, have failed to demonstrate significant depletion of transferrin bound iron by a stoichiometric excess of desferrioxamine. However, low molecular weight chelating agents, capable of forming ternary complexes with transferrin and ferric iron, can promote a rapid transfer of iron from transferrin to desferrioxamine. A possible mechanism for this facilitated exchange is offered.

Original languageEnglish (US)
Pages (from-to)231-235
Number of pages5
JournalBritish Journal of Haematology
Volume34
Issue number2
StatePublished - 1976

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Deferoxamine
Transferrin
Iron
Iron Overload
beta-Thalassemia
Chelating Agents
Molecular Weight

ASJC Scopus subject areas

  • Hematology

Cite this

Chelate mediated transfer of iron from transferrin to desferrioxamine. / Pollack, Simeon; Aisen, P.; Lasky, F. D.; Vanderhoff, G.

In: British Journal of Haematology, Vol. 34, No. 2, 1976, p. 231-235.

Research output: Contribution to journalArticle

Pollack, S, Aisen, P, Lasky, FD & Vanderhoff, G 1976, 'Chelate mediated transfer of iron from transferrin to desferrioxamine', British Journal of Haematology, vol. 34, no. 2, pp. 231-235.
Pollack, Simeon ; Aisen, P. ; Lasky, F. D. ; Vanderhoff, G. / Chelate mediated transfer of iron from transferrin to desferrioxamine. In: British Journal of Haematology. 1976 ; Vol. 34, No. 2. pp. 231-235.
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