TY - JOUR
T1 - Chelate Mediated Transfer of Iron from Transferrin to Desferrioxamine
AU - Pollack, Simeon
AU - Aisen, Philip
AU - Lasky, Fred D.
AU - Vanderhoff, Grace
PY - 1976/10
Y1 - 1976/10
N2 - SUMMARY. Desferrioxamine, widely used for the treatment of iron overload in Cooley's anaemia, binds iron so tightly that it should quantitatively remove iron from transferrin. Studies conducted in vivo and in vitro, however, have failed to demonstrate significant depletion of transferrin‐bound iron by a stoichiometric excess of desferrioxamine. However, low molecular weight chelating agents, capable of forming ternary complexes with transferrin and ferric iron, can promote a rapid transfer of iron from transferrin to desferrioxamine. A possible mechanism for this facilitated exchange is offered.
AB - SUMMARY. Desferrioxamine, widely used for the treatment of iron overload in Cooley's anaemia, binds iron so tightly that it should quantitatively remove iron from transferrin. Studies conducted in vivo and in vitro, however, have failed to demonstrate significant depletion of transferrin‐bound iron by a stoichiometric excess of desferrioxamine. However, low molecular weight chelating agents, capable of forming ternary complexes with transferrin and ferric iron, can promote a rapid transfer of iron from transferrin to desferrioxamine. A possible mechanism for this facilitated exchange is offered.
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U2 - 10.1111/j.1365-2141.1976.tb00193.x
DO - 10.1111/j.1365-2141.1976.tb00193.x
M3 - Article
C2 - 974036
AN - SCOPUS:0017194077
SN - 0007-1048
VL - 34
SP - 231
EP - 235
JO - British Journal of Haematology
JF - British Journal of Haematology
IS - 2
ER -