Chelate Mediated Transfer of Iron from Transferrin to Desferrioxamine

Simeon Pollack, Philip Aisen, Fred D. Lasky, Grace Vanderhoff

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

SUMMARY. Desferrioxamine, widely used for the treatment of iron overload in Cooley's anaemia, binds iron so tightly that it should quantitatively remove iron from transferrin. Studies conducted in vivo and in vitro, however, have failed to demonstrate significant depletion of transferrin‐bound iron by a stoichiometric excess of desferrioxamine. However, low molecular weight chelating agents, capable of forming ternary complexes with transferrin and ferric iron, can promote a rapid transfer of iron from transferrin to desferrioxamine. A possible mechanism for this facilitated exchange is offered.

Original languageEnglish (US)
Pages (from-to)231-235
Number of pages5
JournalBritish Journal of Haematology
Volume34
Issue number2
DOIs
StatePublished - Oct 1976

ASJC Scopus subject areas

  • Hematology

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