Characterization of the taxol structure-activity profile for the locus of the A-ring side chain

Charles S. Swindell, Julia M. Heerding, Nancy E. Krauss, Susan B. Horwitz, Israel Ringel

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Two series of taxol analogs with various N-acyl groups on 3′-phenylisoserine and isoserine A-ring side chains, respectively, were prepared, and their microtubule assembly acitivities and cytotoxicities toward J774.2 cells were evaluated. Biological activities were adversely affected by the structural modifications investigated, although the 3′-phenylisoserine series was significantly more active than the isoserine series.

Original languageEnglish (US)
Pages (from-to)1531-1536
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume4
Issue number12
DOIs
Publication statusPublished - Jun 23 1994

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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