Characterization of the taxol structure-activity profile for the locus of the A-ring side chain

Charles S. Swindell, Julia M. Heerding, Nancy E. Krauss, Susan Band Horwitz, Israel Ringel

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Two series of taxol analogs with various N-acyl groups on 3′-phenylisoserine and isoserine A-ring side chains, respectively, were prepared, and their microtubule assembly acitivities and cytotoxicities toward J774.2 cells were evaluated. Biological activities were adversely affected by the structural modifications investigated, although the 3′-phenylisoserine series was significantly more active than the isoserine series.

Original languageEnglish (US)
Pages (from-to)1531-1536
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume4
Issue number12
DOIs
StatePublished - Jun 23 1994

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Paclitaxel
Cytotoxicity
Bioactivity
Microtubules
isoserine
beta-phenylisoserine

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Characterization of the taxol structure-activity profile for the locus of the A-ring side chain. / Swindell, Charles S.; Heerding, Julia M.; Krauss, Nancy E.; Band Horwitz, Susan; Ringel, Israel.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 4, No. 12, 23.06.1994, p. 1531-1536.

Research output: Contribution to journalArticle

Swindell, Charles S. ; Heerding, Julia M. ; Krauss, Nancy E. ; Band Horwitz, Susan ; Ringel, Israel. / Characterization of the taxol structure-activity profile for the locus of the A-ring side chain. In: Bioorganic and Medicinal Chemistry Letters. 1994 ; Vol. 4, No. 12. pp. 1531-1536.
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